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Aliases for ARFIP2 Gene
Aliases for ARFIP2 Gene
External Ids for ARFIP2 Gene
- HGNC: 17160
- Entrez Gene: 23647
- Ensembl: ENSG00000132254
- OMIM: 601638
- UniProtKB: P53365
Previous GeneCards Identifiers for ARFIP2 Gene
- GC11M006455
- GC11M006461
- GC11M006453
- GC11M006496
- GC11M006156
Summaries for ARFIP2 Gene
GeneCards Summary for ARFIP2 Gene
ARFIP2 (ADP Ribosylation Factor Interacting Protein 2) is a Protein Coding gene. Diseases associated with ARFIP2 include Gastric Papillary Adenocarcinoma and Signet Ring Cell Adenocarcinoma. Among its related pathways are G-protein signaling RAC1 in cellular process and Development EGFR signaling via small GTPases. Gene Ontology (GO) annotations related to this gene include GTP binding and Rac GTPase binding. An important paralog of this gene is ARFIP1.
UniProtKB/Swiss-Prot Summary for ARFIP2 Gene
-
Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site (PubMed:31204568). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658).
Additional gene information for ARFIP2 Gene
- HGNC(17160)
- Entrez Gene(23647)
- Ensembl(ENSG00000132254)
- OMIM(601638)
- UniProtKB(P53365)
- Open Targets Platform(ENSG00000132254)
- Search for ARFIP2 at DataMed
- Search for ARFIP2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARFIP2 Gene
Genomics for ARFIP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARFIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARFIP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARFIP2
- Top Transcription factor binding sites by QIAGEN in the ARFIP2 gene promoter:
-
- AREB6
- ATF
- Egr-2
- GR
- GR-alpha
- Hlf
- Pax-4a
- PPAR-gamma1
- PPAR-gamma2
- TGIF
Genomic Locations for ARFIP2 Gene
Genomic Locations for ARFIP2 Gene
- chr11:6,474,683-6,481,479
- (GRCh38/hg38)
- Size:
- 6,797 bases
- Orientation:
- Minus strand
- chr11:6,495,913-6,502,709
- (GRCh37/hg19)
- Size:
- 6,797 bases
- Orientation:
- Minus strand
Genomic View for ARFIP2 Gene
Genes around ARFIP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by HGNC
- 11p15.4 by Entrez Gene
- 11p15.4 by Ensembl
ARFIP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARFIP2 Gene
Proteins for ARFIP2 Gene
-
Protein details for ARFIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53365-ARFP2_HUMAN
- Recommended name:
- Arfaptin-2
- Protein Accession:
- P53365
- B4DX86
- B4E306
- D3DQT5
Protein attributes for ARFIP2 Gene
- Size:
- 341 amino acids
- Molecular mass:
- 37856 Da
- Quaternary structure:
-
- Forms homodimers or heterodimers with ARFIP1 (PubMed:21239483). Interacts with RAC1 (PubMed:11346801). Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities. Interacts with ARL1 (PubMed:11303027, PubMed:22679020, PubMed:26507660). Interacts (via N-terminus) with IKBKB and IKBKG; these interactions inhibit activation of NF-kappa-B (PubMed:26296658).
Three dimensional structures from OCA and Proteopedia for ARFIP2 Gene
Protein Expression for ARFIP2 Gene
Post-translational modifications for ARFIP2 Gene
Other Protein References for ARFIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-ARFIP2 monoclonal antibody, clone FQS22054
- Novus Biologicals Antibodies for ARFIP2
- Invitrogen Antibodies for ARFIP2 (AFLGC-ARFIP2)
-
Biorbyt antibodies for ARFIP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARFIP2
Protein Products
-
OriGene Purified Proteins for ARFIP2
- Search Origene for MassSpec and Protein Over-expression Lysates for ARFIP2
- Origene Custom Protein Services for ARFIP2
- ProSpec Recombinant Proteins for ARFIP2
- antibodies-online: Show 8 available ARFIP2 Proteins ranked by validation data
- Compare Top ARFIP2 Proteins
-
Quality Products:
-
Abcam proteins for ARFIP2
No data available for DME Specific Peptides for ARFIP2 Gene
Domains & Families for ARFIP2 Gene
Gene Families for ARFIP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ARFIP2 Gene
- InterPro:
- Blocks:
-
- Arfaptin-like
- ProtoNet:
Suggested Antigen Peptide Sequences for ARFIP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Partner of RAC1 (ARFP2_HUMAN)
- cDNA FLJ51194, highly similar to Arfaptin-2 (B4E306_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARFIP2 Gene
Function for ARFIP2 Gene
Molecular function for ARFIP2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site (PubMed:31204568). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 8670882 |
| GO:0005525 | GTP binding | TAS | 8670882 |
| GO:0005543 | phospholipid binding | IBA | 21873635 |
| GO:0019904 | protein domain specific binding | IEA | -- |
| GO:0030742 | GTP-dependent protein binding | IPI | 9312003 |
Phenotypes for ARFIP2 Gene
- GenomeRNAi human phenotypes for ARFIP2:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Reduced mammosphere formation
- Decreased POU5F1-GFP protein expression
- Decreased viability in colon lineage
- Decreased circadian period length
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARFIP2 - Select products 50% OFF >
- * ARFIP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ARFIP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARFIP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARFIP2
miRNA for ARFIP2 Gene
- miRTarBase miRNAs that target ARFIP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARFIP2
- Browse OriGene Inhibitory RNA Products For ARFIP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARFIP2
Clone Products
- Applied Biological Materials (abm): Clones for ARFIP2 - Select products 50% OFF >
- * ARFIP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ARFIP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARFIP2
Cell Line Products
-
Horizon Cell Lines for ARFIP2
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFIP2 Gene
Localization for ARFIP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARFIP2 Gene
- Golgi apparatus. Golgi apparatus, trans-Golgi network membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Golgi apparatus (2)
- Nucleoli fibrillar center (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | IMP | 8670882 |
| GO:0005737 | cytoplasm | IBA,TAS | 9312003 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | 9312003 |
Pathways & Interactions for ARFIP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | fMLP Pathway |
Huntington's Disease Pathway
.31
|
|
| 3 | GPCR Pathway |
Paxillin Interactions
.73
|
|
| 4 | TCR Signaling (Qiagen) |
PDGF Pathway
.39
|
|
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
Rac1 Pathway
.65
|
|
Pathways by source for ARFIP2 Gene
2 BioSystems pathways for ARFIP2 Gene
4 Reactome pathways for ARFIP2 Gene
2 GeneGo (Thomson Reuters) pathways for ARFIP2 Gene
- Cytoskeleton remodeling_Role of PDGFs in cell migration
- G-protein signaling RAC1 in cellular process
5 Qiagen pathways for ARFIP2 Gene
- Huntington's Disease Pathway
- Paxillin Interactions
- PDGF Pathway
- Rac1 Pathway
- Rho Family GTPases
Interacting Proteins for ARFIP2 Gene
Selected Interacting proteins:
P53365-ARFP2_HUMAN
ENSP00000484121
for ARFIP2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ARFIP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | IBA | 21873635 |
| GO:0006914 | autophagy | IEA | -- |
| GO:0007264 | small GTPase mediated signal transduction | TAS | 8670882 |
| GO:0030032 | lamellipodium assembly | TAS | 9312003 |
| GO:0030036 | actin cytoskeleton organization | IMP | 9312003 |
Drugs & Compounds for ARFIP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for ARFIP2 Gene
mRNA/cDNA for ARFIP2 Gene
- 17 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000254584 2543 nts (view in UCSC)
- ENST00000396777 1868 nts (view in UCSC)
- ENST00000531037 1560 nts (view in UCSC)
- ENST00000445086 1300 nts (view in UCSC)
- ENST00000423813 1430 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARFIP2 - Select products 50% OFF >
- * ARFIP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ARFIP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARFIP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARFIP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARFIP2
- Browse OriGene Inhibitory RNA Products For ARFIP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARFIP2
Clone Products
- Applied Biological Materials (abm): Clones for ARFIP2 - Select products 50% OFF >
- * ARFIP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ARFIP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARFIP2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP25: |
| ExUns: | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | · | 11f | · | 11g | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||||
| SP23: | |||||||||||||||||||||||||||||
| SP24: | |||||||||||||||||||||||||||||
| SP25: | - | - |
Relevant External Links for ARFIP2 Gene
- GeneLoc Exon Structure for
- ARFIP2
Expression for ARFIP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Nasal epithelium (13.4), Skin (12.3), Brain (10.5), and Oral epithelium (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARFIP2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARFIP2
SOURCE GeneReport for Unigene cluster for ARFIP2 Gene:
Hs.75139Evidence on tissue expression from TISSUES for ARFIP2 Gene
- Nervous system(4.6)
- Liver(4.4)
- Lung(4.4)
- Kidney(2.7)
- Intestine(2.7)
- Stomach(2.5)
- Skin(2.4)
- Lymph node(2.3)
- Pancreas(2.2)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for ARFIP2
-
OriGene qPCR primer pairs and template standards for ARFIP2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARFIP2 Gene
Orthologs for ARFIP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARFIP2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ARFIP2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ARFIP2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ARFIP2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Arfip2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Arfip2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ARFIP2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ARFIP2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ARFIP2 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | arfip2b 30 31 |
|
OneToMany | |
| arfip2a 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG17184 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004910 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | F54C8.7 30 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9407 31 |
|
OneToMany |
- Species where no ortholog for ARFIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for ARFIP2 Gene
- ENSEMBL:
- Gene Tree for ARFIP2 (if available)
- TreeFam:
- Gene Tree for ARFIP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARFIP2: view image
Paralogs for ARFIP2 Gene
Variants for ARFIP2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3625266 | CNV | gain | 21293372 |
| nsv972944 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.52;
11.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARFIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARFIP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARFIP2 Gene
Disorders for ARFIP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric papillary adenocarcinoma |
|
|
| signet ring cell adenocarcinoma |
|
|
Search ARFIP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARFIP2
No data available for UniProtKB/Swiss-Prot and Genatlas for ARFIP2 Gene
Publications for ARFIP2 Gene
- Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PMID: 9038142) Kanoh H … Exton JH (The Journal of biological chemistry 1997) 2 3 4
- Identification of a novel Rac1-interacting protein involved in membrane ruffling. (PMID: 8670882) Van Aelst L … Bar-Sagi D (The EMBO journal 1996) 2 3 4
- Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity. (PMID: 26296658) You DJ … Hwang JI (Cellular signalling 2015) 3 4
- Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. (PMID: 22679020) Nakamura K … Wakatsuki S (The Journal of biological chemistry 2012) 3 4
- Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment. (PMID: 15809304) Rangone H … Humbert S (The Journal of biological chemistry 2005) 3 23
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