Aliases for ARFIP2 Gene
Aliases for ARFIP2 Gene
External Ids for ARFIP2 Gene
- HGNC: 17160
- Entrez Gene: 23647
- Ensembl: ENSG00000132254
- OMIM: 601638
- UniProtKB: P53365
Previous GeneCards Identifiers for ARFIP2 Gene
- GC11M006455
- GC11M006461
- GC11M006453
- GC11M006156
Summaries for ARFIP2 Gene
GeneCards Summary for ARFIP2 Gene
ARFIP2 (ADP Ribosylation Factor Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Arf1 pathway and G-protein signaling RAC1 in cellular process. Gene Ontology (GO) annotations related to this gene include GTP binding and Rac GTPase binding. An important paralog of this gene is ARFIP1.
UniProtKB/Swiss-Prot for ARFIP2 Gene
-
Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.
Additional gene information for ARFIP2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFIP2 Gene
Genomics for ARFIP2 Gene
GeneHancer (GH) Regulatory Elements for ARFIP2 Gene
Promoters and enhancers for ARFIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ARFIP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ARFIP2 gene promoter:
Regulatory Element Products
Genomic Locations for ARFIP2 Gene
Genomic Locations for ARFIP2 Gene
- chr11:6,474,683-6,481,479
- (GRCh38/hg38)
- Size:
- 6,797 bases
- Orientation:
- Minus strand
- chr11:6,495,913-6,502,709
- (GRCh37/hg19)
Genomic View for ARFIP2 Gene
Genes around ARFIP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC
- 11p15.4 by Ensembl
ARFIP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARFIP2 Gene
Proteins for ARFIP2 Gene
-
Protein details for ARFIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53365-ARFP2_HUMAN
- Recommended name:
- Arfaptin-2
- Protein Accession:
- P53365
- B4DX86
- B4E306
- D3DQT5
Protein attributes for ARFIP2 Gene
- Size:
- 341 amino acids
- Molecular mass:
- 37856 Da
- Quaternary structure:
-
- Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities. Directly interacts with ARL1 GTP-bound form; this interaction leads to a > 4-fold increase in the amount of ARL1-bound GTP at steady state level.
Three dimensional structures from OCA and Proteopedia for ARFIP2 Gene
Protein Expression for ARFIP2 Gene
Post-translational modifications for ARFIP2 Gene
Other Protein References for ARFIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ARFIP2
- Invitrogen Antibodies for ARFIP2
- GeneTex ARFIP2 Antibody for ARFIP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARFIP2
Protein Products
-
OriGene Purified Proteins for ARFIP2
- Search Origene for MassSpec and Protein Over-expression Lysates for ARFIP2
- Origene Custom Protein Services for ARFIP2
- ProSpec Recombinant Proteins for ARFIP2
- antibodies-online: Search results for 8 available ARFIP2 Proteins ranked by validation data
- Compare Top ARFIP2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ARFIP2
Assay Products
No data available for DME Specific Peptides for ARFIP2 Gene
Domains & Families for ARFIP2 Gene
Gene Families for ARFIP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for ARFIP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARFIP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ARFIP2 Gene
Function for ARFIP2 Gene
Molecular function for ARFIP2 Gene
- UniProtKB/Swiss-Prot Function:
- Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 8670882 |
| GO:0005525 | GTP binding | TAS | 8670882 |
| GO:0005543 | phospholipid binding | IBA | -- |
| GO:0019904 | protein domain specific binding | IEA | -- |
| GO:0030742 | GTP-dependent protein binding | IPI | 9312003 |
Phenotypes for ARFIP2 Gene
- GenomeRNAi human phenotypes for ARFIP2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ARFIP2
-
CRISPR Products
-
OriGene CRISPR knockouts for ARFIP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARFIP2
- genomics-online: gRNA clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
- Applied Biological Materials CRISPR for ARFIP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARFIP2
- GenScript: Design CRISPR guide RNA sequences for ARFIP2
miRNA for ARFIP2 Gene
- miRTarBase miRNAs that target ARFIP2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ARFIP2
- Browse OriGene Inhibitory RNA Products For ARFIP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARFIP2
- genomics-online: shRNA clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ARFIP2
- VectorBuilder custom plasmid, inducible vectors for ARFIP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARFIP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARFIP2
- Applied Biological Materials Clones for ARFIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ARFIP2
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFIP2 Gene
Localization for ARFIP2 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Golgi apparatus (2)
- Nucleoli fibrillar center (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | IMP | 8670882 |
| GO:0005737 | cytoplasm | IDA,TAS | 9312003 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | 9312003 |
| GO:0005938 | cell cortex | IDA | 9312003 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARFIP2 Gene
Pathways & Interactions for ARFIP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | fMLP Pathway | ||
| 3 | GPCR Pathway | ||
| 4 | TCR Signaling (Qiagen) |
.39
|
|
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
.65
|
|
Pathways by source for ARFIP2 Gene
2 BioSystems pathways for ARFIP2 Gene
4 Reactome pathways for ARFIP2 Gene
2 GeneGo (Thomson Reuters) pathways for ARFIP2 Gene
5 Qiagen pathways for ARFIP2 Gene
Interacting Proteins for ARFIP2 Gene
Selected Interacting proteins:
P53365-ARFP2_HUMAN
ENSP00000254584
for ARFIP2 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for ARFIP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | IBA | -- |
| GO:0007264 | small GTPase mediated signal transduction | TAS | 8670882 |
| GO:0030032 | lamellipodium assembly | TAS | 9312003 |
| GO:0030036 | actin cytoskeleton organization | IMP | 9312003 |
| GO:0031529 | ruffle organization | TAS | 9312003 |
Drugs & Compounds for ARFIP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for ARFIP2 Gene
mRNA/cDNA for ARFIP2 Gene
- (436) Selected AceView cDNA sequences:
- (10) Additional mRNA sequences :
- (5) REFSEQ mRNAs :
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000254584 2543 bps (uc001mdk.4)
- ENST00000396777 1868 bps (uc057ylj.1)
- ENST00000423813 1430 bps (uc010ral.3)
- ENST00000445086 1300 bps (uc010ram.3)
- ENST00000525235 852 bps (uc057yll.1)
Unigene Clusters for ARFIP2 Gene
- ADP-ribosylation factor interacting protein 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ARFIP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARFIP2
- genomics-online: gRNA clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
- Applied Biological Materials CRISPR for ARFIP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARFIP2
- GenScript: Design CRISPR guide RNA sequences for ARFIP2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ARFIP2
- Browse OriGene Inhibitory RNA Products For ARFIP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARFIP2
- genomics-online: shRNA clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ARFIP2
- VectorBuilder custom plasmid, inducible vectors for ARFIP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARFIP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARFIP2
- Applied Biological Materials Clones for ARFIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP25: |
| ExUns: | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | · | 11f | · | 11g | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||||
| SP23: | |||||||||||||||||||||||||||||
| SP24: | |||||||||||||||||||||||||||||
| SP25: | - | - |
Expression for ARFIP2 Gene
This gene is overexpressed in Nasal epithelium (13.4), Skin (12.3), Brain (10.5), and Oral epithelium (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARFIP2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ARFIP2 Gene:
ARFIP2SOURCE GeneReport for Unigene cluster for ARFIP2 Gene:
Hs.75139Evidence on tissue expression from TISSUES for ARFIP2 Gene
- Liver(4.4)
- Nervous system(4.4)
- Lung(4.3)
- Intestine(2.5)
- Lymph node(2.2)
- Stomach(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ARFIP2
-
OriGene qPCR primer pairs for ARFIP2
- genomics-online: primer clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARFIP2 Gene
Orthologs for ARFIP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ARFIP2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ARFIP2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ARFIP2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ARFIP2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Arfip2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Arfip2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ARFIP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ARFIP2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ARFIP2 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | arfip2b 34 33 |
|
OneToMany | |
| arfip2a 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17184 34 33 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004910 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F54C8.7 34 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9407 34 |
|
OneToMany |
- Species where no ortholog for ARFIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ARFIP2 Gene
- ENSEMBL:
- Gene Tree for ARFIP2 (if available)
- TreeFam:
- Gene Tree for ARFIP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARFIP2: view image
Paralogs for ARFIP2 Gene
Variants for ARFIP2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000365664 | -- | 6,481,926(-) | C/G | upstream_transcript_variant | |
| rs1001483841 | -- | 6,482,248(-) | C/T | upstream_transcript_variant | |
| rs1001714070 | -- | 6,476,408(-) | G/A | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
| rs1002050326 | -- | 6,482,457(-) | A/G | upstream_transcript_variant | |
| rs1002596206 | -- | 6,477,647(-) | G/A | intron_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3625266 | CNV | gain | 21293372 |
| nsv972944 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.52;
11.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARFIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARFIP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFIP2 Gene
Disorders for ARFIP2 Gene
Additional Disease Information for ARFIP2
No disorders were found for ARFIP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFIP2 Gene
Publications for ARFIP2 Gene
- Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. (PMID: 9038142) Kanoh H … Exton JH (The Journal of biological chemistry 1997) 2 3 4 58
- Identification of a novel Rac1-interacting protein involved in membrane ruffling. (PMID: 8670882) Van Aelst L … Bar-Sagi D (The EMBO journal 1996) 2 3 4 58
- Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment. (PMID: 15809304) Rangone H … Humbert S (The Journal of biological chemistry 2005) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. (PMID: 11346801) Tarricone C … Smerdon SJ (Nature 2001) 3 4 58
Products for ARFIP2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ARFIP2
- Search Origene for MassSpec and Protein Over-expression Lysates for ARFIP2
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- GenScript: Next-day shipping of latest version cDNA ORF clones for ARFIP2 in any vector
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- GenScript: Design CRISPR guide RNA sequences for ARFIP2
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- Novus Biologicals Antibodies for ARFIP2
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- Browse Antibodies
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- Browse Lysates
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- ProSpec Recombinant Proteins for ARFIP2
- VectorBuilder custom plasmid, inducible vectors for ARFIP2
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 54 available ARFIP2 Antibodies ranked by validation data
- Compare Top ARFIP2 Antibodies
- antibodies-online: Search results for available ARFIP2 related products ranked by validation data
- antibodies-online: Search results for 8 available ARFIP2 Proteins ranked by validation data
- Compare Top ARFIP2 Proteins
- Quality Products:
- GeneTex ARFIP2 Antibody for ARFIP2
- Search GeneTex for Proteins for ARFIP2
- Santa Cruz Biotechnology (SCBT) Antibodies for ARFIP2
- Search Santa Cruz Biotechnology (SCBT) for ARFIP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ARFIP2
- Horizon Cell Lines for ARFIP2
- genomics-online: cdna clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
- orf clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
- genomics-online: gRNA clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
- genomics-online: primer clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
- genomics-online: shRNA clones - Search results for 117 available ARFIP2 gene related products
- Overview of 117 available ARFIP2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARFIP2
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- GeneCopoeia miRNA 3'UTR Target clone products for ARFIP2
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Sources for ARFIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio