Aliases for ARFIP1 Gene
External Ids for ARFIP1 Gene
Previous GeneCards Identifiers for ARFIP1 Gene
GeneCards Summary for ARFIP1 Gene
ARFIP1 (ADP Ribosylation Factor Interacting Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and phosphatidylinositol-4-phosphate binding. An important paralog of this gene is ARFIP2.
UniProtKB/Swiss-Prot Summary for ARFIP1 Gene
Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.