Aliases for ARFGEF3 Gene
External Ids for ARFGEF3 Gene
Previous HGNC Symbols for ARFGEF3 Gene
GeneCards Summary for ARFGEF3 Gene
ARFGEF3 (ARFGEF Family Member 3) is a Protein Coding gene. Diseases associated with ARFGEF3 include Breast Cancer. Gene Ontology (GO) annotations related to this gene include binding and ARF guanyl-nucleotide exchange factor activity.
UniProtKB/Swiss-Prot Summary for ARFGEF3 Gene
Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786).