Aliases for ARFGAP1 Gene
Aliases for ARFGAP1 Gene
- ADP Ribosylation Factor GTPase Activating Protein 1 2 3 5
- ARF1-Directed GTPase-Activating Protein 3 4
- ARF1GAP 3 4
- ADP-Ribosylation Factor 1 GTPase Activating Protein 2
- ADP-Ribosylation Factor GTPase-Activating Protein 1 3
- ADP-Ribosylation Factor 1 GTPase-Activating Protein 4
- HRIHFB2281 3
- ARF GAP 1 4
- ARF1 GAP 4
External Ids for ARFGAP1 Gene
- HGNC: 15852
- Entrez Gene: 55738
- Ensembl: ENSG00000101199
- OMIM: 608377
- UniProtKB: Q8N6T3
Previous HGNC Symbols for ARFGAP1 Gene
- ARF1GAP
Previous GeneCards Identifiers for ARFGAP1 Gene
- GC20P061781
- GC20P062583
- GC20P062630
- GC20P061374
- GC20P061904
- GC20P058629
Summaries for ARFGAP1 Gene
-
The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for ARFGAP1 Gene
ARFGAP1 (ADP Ribosylation Factor GTPase Activating Protein 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTPase activator activity.
UniProtKB/Swiss-Prot for ARFGAP1 Gene
-
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicles fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).
Additional gene information for ARFGAP1 Gene
- Monarch Initiative
- Search for ARFGAP1 at DataMed
- Search for ARFGAP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFGAP1 Gene
Genomics for ARFGAP1 Gene
GeneHancer (GH) Regulatory Elements for ARFGAP1 Gene
Promoters and enhancers for ARFGAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ARFGAP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ARFGAP1 gene promoter:
Regulatory Element Products
Genomic Locations for ARFGAP1 Gene
Genomic Locations for ARFGAP1 Gene
- chr20:63,272,785-63,289,793
- (GRCh38/hg38)
- Size:
- 17,009 bases
- Orientation:
- Plus strand
- chr20:61,904,137-61,921,142
- (GRCh37/hg19)
Genomic View for ARFGAP1 Gene
Genes around ARFGAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.33 by Ensembl
- 20q13.33 by Entrez Gene
- 20q13.33 by HGNC
ARFGAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARFGAP1 Gene
Proteins for ARFGAP1 Gene
-
Protein details for ARFGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N6T3-ARFG1_HUMAN
- Recommended name:
- ADP-ribosylation factor GTPase-activating protein 1
- Protein Accession:
- Q8N6T3
- B7Z3U0
- B7Z8H8
- B7ZBI3
- E1P5I9
- E7EV62
- Q6PK71
- Q96KC4
- Q96T02
- Q9NSU3
- Q9NVF6
- Q9UIL0
Protein attributes for ARFGAP1 Gene
- Size:
- 406 amino acids
- Molecular mass:
- 44668 Da
- Quaternary structure:
-
- Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. The interaction with TMED2 inhibits the GAP activity (By similarity).
- SequenceCaution:
-
- Sequence=BAB55009.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55113.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB70901.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
Protein Expression for ARFGAP1 Gene
Post-translational modifications for ARFGAP1 Gene
- Ubiquitination at Lys102 and Lys278
Other Protein References for ARFGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for ARFGAP1 (ARF GAP1)
- Novus Biologicals Antibodies for ARFGAP1
-
Abcam antibodies for ARFGAP1
- Invitrogen Antibodies for ARFGAP1
- Search GeneTex for Antibodies for ARFGAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARFGAP1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ARFGAP1
- Origene Custom Protein Services for ARFGAP1
- Search GeneTex for Proteins for ARFGAP1
-
Abcam proteins for ARFGAP1
Assay Products
No data available for DME Specific Peptides for ARFGAP1 Gene
Domains & Families for ARFGAP1 Gene
Gene Families for ARFGAP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ARFGAP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARFGAP1 Gene
Graphical View of Domain Structure for InterPro Entry
Q8N6T3UniProtKB/Swiss-Prot:
ARFG1_HUMAN :- The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity).
- Domain:
-
- The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity).
Function for ARFGAP1 Gene
Molecular function for ARFGAP1 Gene
- UniProtKB/Swiss-Prot Function:
- GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicles fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).
Phenotypes From GWAS Catalog for ARFGAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IDA | 22423108 |
| GO:0005515 | protein binding | IPI | 22363216 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ARFGAP1 Gene
- GenomeRNAi human phenotypes for ARFGAP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ARFGAP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ARFGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ARFGAP1 gene
- Search ViGene Biosciences for ARFGAP1
CRISPR Products
-
OriGene CRISPR knockouts for ARFGAP1
- genomics-online: gRNA clones - Search results for 181 available ARFGAP1 gene related products
- Overview of 181 available ARFGAP1 gene related products
- Applied Biological Materials CRISPR for ARFGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARFGAP1
- GenScript: Design CRISPR guide RNA sequences for ARFGAP1
miRNA for ARFGAP1 Gene
- miRTarBase miRNAs that target ARFGAP1
miRNA Products
- Search ViGene Biosciences for ARFGAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ARFGAP1
- Browse OriGene Inhibitory RNA Products For ARFGAP1
- genomics-online: shRNA clones - Search results for 181 available ARFGAP1 gene related products
- Overview of 181 available ARFGAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ARFGAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for ARFGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ARFGAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARFGAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ARFGAP1
- Applied Biological Materials Clones for ARFGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ARFGAP1
-
ViGene Biosciences adenoviral particle packaged cDNA for ARFGAP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ARFGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ARFGAP1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFGAP1 Gene
Localization for ARFGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARFGAP1 Gene
- Cytoplasm. Golgi apparatus. Note=Associates with the Golgi complex. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| golgi apparatus | 5 |
| nucleus | 4 |
- Golgi apparatus (3)
- Vesicles (3)
- Nuclear membrane (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0014069 | postsynaptic density | IEA | -- |
| GO:0045202 | synapse | IEA | -- |
Pathways & Interactions for ARFGAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport to the Golgi and subsequent modification | ||
| 2 | Golgi-to-ER retrograde transport | ||
| 3 | Unfolded Protein Response (UPR) | ||
| 4 | Vesicle-mediated transport | ||
| 5 | Metabolism of proteins | ||
Pathways by source for ARFGAP1 Gene
1 Cell Signaling Technology pathway for ARFGAP1 Gene
1 BioSystems pathway for ARFGAP1 Gene
1 KEGG pathway for ARFGAP1 Gene
2 Qiagen pathways for ARFGAP1 Gene
Interacting Proteins for ARFGAP1 Gene
Selected Interacting proteins:
ENSP00000314615
Q8N6T3-ARFG1_HUMAN
for ARFGAP1 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | TAS | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0016192 | vesicle-mediated transport | IEA | -- |
Drugs & Compounds for ARFGAP1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PC(18:1(9Z)e/2:0) |
|
|
||||
| Phosphatidylcholines Group A |
|
68737-67-7 |
|
|||
| Phosphatidylcholines Group B |
|
88542-95-4 |
|
(1) ApexBio Compounds for ARFGAP1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| HJC 0350 | 885434-70-8 |
Transcripts for ARFGAP1 Gene
mRNA/cDNA for ARFGAP1 Gene
- (8) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (445) Selected AceView cDNA sequences:
- (23) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ARFGAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ARFGAP1
- genomics-online: gRNA clones - Search results for 181 available ARFGAP1 gene related products
- Overview of 181 available ARFGAP1 gene related products
- Applied Biological Materials CRISPR for ARFGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARFGAP1
- GenScript: Design CRISPR guide RNA sequences for ARFGAP1
miRNA Products
- Search ViGene Biosciences for ARFGAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ARFGAP1
- Browse OriGene Inhibitory RNA Products For ARFGAP1
- genomics-online: shRNA clones - Search results for 181 available ARFGAP1 gene related products
- Overview of 181 available ARFGAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ARFGAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for ARFGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ARFGAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARFGAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ARFGAP1
- Applied Biological Materials Clones for ARFGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 15c | · | 15d | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||
| SP13: | - | - | - | ||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||
| SP17: |
Expression for ARFGAP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
This gene is overexpressed in Bone (14.3), Peripheral blood mononuclear cells (6.6), and Bone marrow stromal cell (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARFGAP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ARFGAP1 Gene:
ARFGAP1SOURCE GeneReport for Unigene cluster for ARFGAP1 Gene:
Hs.25584Evidence on tissue expression from TISSUES for ARFGAP1 Gene
- Nervous system(5)
- Liver(4.2)
- Lung(2.2)
- Skin(2.2)
Primer Products
-
OriGene qPCR primer pairs for ARFGAP1
-
OriGene qPCR primer pairs and template standards for ARFGAP1
- genomics-online: primer clones - Search results for 181 available ARFGAP1 gene related products
- Overview of 181 available ARFGAP1 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARFGAP1 Gene
Orthologs for ARFGAP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ARFGAP1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Arfgap1 33 16 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ARFGAP1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Arfgap1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | ARFGAP1 33 |
|
||
| ARFGAP3 34 |
|
OneToOne | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ARFGAP1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ARFGAP1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ARFGAP1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ARFGAP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | arfgap1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25766 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | arfgap1 33 |
|
||
| ARFGAP1 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6838 35 |
|
|
|
| Gap69C 34 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | K02B12.7 34 |
|
OneToOne | |
| F07F6.4 35 |
|
|
|||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ABL164C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GCS1 34 36 33 |
|
OneToMany | |
| SPS18 34 |
|
OneToMany | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D18942g 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU07734 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC622.14 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6254 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.11804 33 |
|
- Species where no ortholog for ARFGAP1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ARFGAP1 Gene
(28) SIMAP similar genes for ARFGAP1 Gene using alignment to 12 proteins:
No data available for Paralogs for ARFGAP1 Gene
Variants for ARFGAP1 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000559806 | -- | 63,283,341(+) | A/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000620740 | -- | 63,279,148(+) | T/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000624378 | -- | 63,287,468(+) | G/A | intron_variant | |
| rs1000646106 | -- | 63,290,250(+) | A/G | downstream_transcript_variant | |
| rs1000882496 | -- | 63,279,521(+) | C/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.97;
36.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARFGAP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARFGAP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFGAP1 Gene
Disorders for ARFGAP1 Gene
Additional Disease Information for ARFGAP1
No disorders were found for ARFGAP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFGAP1 Gene
Publications for ARFGAP1 Gene
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
- Expression, purification, and properties of ADP-ribosylation factor (ARF) GTPase activating protein-1. (PMID: 11210549) Huber I … Cassel D (Methods in enzymology 2001) 2 3 58
Products for ARFGAP1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
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- Custom Antibody ServicesOriGene Antibodies for ARFGAP1
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- Invitrogen Antibodies for ARFGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- Mammalian expression: PiggyBac
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- Addgene plasmids for ARFGAP1