This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of t... See more...

Aliases for ARF5 Gene

Aliases for ARF5 Gene

  • ADP Ribosylation Factor 5 2 3 5
  • ADP-Ribosylation Factor 5 3 4
  • ARF5 5

External Ids for ARF5 Gene

Previous GeneCards Identifiers for ARF5 Gene

  • GC07P125706
  • GC07P126771
  • GC07P126782
  • GC07P126822
  • GC07P127015
  • GC07P127228
  • GC07P121589

Summaries for ARF5 Gene

Entrez Gene Summary for ARF5 Gene

  • This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]

GeneCards Summary for ARF5 Gene

ARF5 (ADP Ribosylation Factor 5) is a Protein Coding gene. Diseases associated with ARF5 include Cholera and Geroderma Osteodysplasticum. Among its related pathways are Transport to the Golgi and subsequent modification and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARF4.

UniProtKB/Swiss-Prot Summary for ARF5 Gene

  • GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
  • (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

Gene Wiki entry for ARF5 Gene

Additional gene information for ARF5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARF5 Gene

Genomics for ARF5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J127584 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -1.7 -1664 6.6 SP1 CREB1 GATAD2A CTCF ATF7 PRDM10 REST ZNF629 IKZF1 POLR2A GCC1 ARF5 FSCN3 NONHSAG048721.2 piR-39614 SND1 RBM28 ENSG00000224138 NONHSAG048722.2-001 ZNF800
GH07J127632 Enhancer 0.6 Ensembl ENCODE 11.1 +44.6 44614 1.6 ZSCAN4 BHLHE40 ATF4 SND1 GCC1 FSCN3 ARF5 RF00017-6588 PAX4 ENSG00000240790
GH07J127694 Enhancer 0.3 Ensembl 10.6 +105.1 105115 0.2 HLF SND1 ENSG00000240790 GCC1 FSCN3 ARF5 LRRC4 LEP piR-54129 HSALNG0061154
GH07J127286 Enhancer 0.2 Ensembl 4.6 -301.2 -301185 0.8 GRM8-AS1 ARF5 PRELID3BP10 lnc-ARF5-13 GRM8 ZNF800
GH07J127578 Enhancer 0.6 Ensembl 0.4 -9.3 -9286 1 PRDM10 CTCF JUND KLF13 NFIC ZNF366 YY1 ZNF398 ZNF2 RAD21 SND1 PAX4 ENSG00000240790 piR-36285 ARF5 lnc-ARF5-8 ZNF800
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARF5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARF5

Top Transcription factor binding sites by QIAGEN in the ARF5 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Chx10
  • E47
  • GATA-2
  • GATA-3
  • Hand1
  • Nkx2-5

Genomic Locations for ARF5 Gene

Genomic Locations for ARF5 Gene
chr7:127,588,386-127,591,700
(GRCh38/hg38)
Size:
3,315 bases
Orientation:
Plus strand
chr7:127,228,399-127,231,759
(GRCh37/hg19)
Size:
3,361 bases
Orientation:
Plus strand

Genomic View for ARF5 Gene

Genes around ARF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF5 Gene

Proteins for ARF5 Gene

  • Protein details for ARF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84085-ARF5_HUMAN
    Recommended name:
    ADP-ribosylation factor 5
    Protein Accession:
    P84085
    Secondary Accessions:
    • P26437

    Protein attributes for ARF5 Gene

    Size:
    180 amino acids
    Molecular mass:
    20530 Da
    Quaternary structure:
    • Interacts (when activated) with GGA1, GGA2 and GGA3; the interaction is required for proper subcellular location of GGA1, GGA2 and GGA3 (PubMed:11950392). Binds ASAP2 (PubMed:10022920). Interacts with NCS1/FREQ at the Golgi complex (PubMed:17555535). Interacts with RAB11FIP3 and RAB11FIP4 (PubMed:17030804).

    Three dimensional structures from OCA and Proteopedia for ARF5 Gene

neXtProt entry for ARF5 Gene

Post-translational modifications for ARF5 Gene

  • Ubiquitination at Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for ARF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ARF5
  • Boster Bio Antibodies for ARF5
  • Santa Cruz Biotechnology (SCBT) Antibodies for ARF5

No data available for DME Specific Peptides for ARF5 Gene

Domains & Families for ARF5 Gene

Gene Families for ARF5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARF5 Gene

Suggested Antigen Peptide Sequences for ARF5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92389, Homo sapiens ADP-ribosylation factor 5 (ARF5), mRNA (A4D0Z3_HUMAN)
  • ADP-ribosylation factor 5 (ARF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P84085

UniProtKB/Swiss-Prot:

ARF5_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF5: view

Function for ARF5 Gene

Molecular function for ARF5 Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
GENATLAS Biochemistry:
ADP-ribosylation factor 5,class II,20kDa,low molecular weight GTP binding protein ,a guanine nucleotide dependent protein activator of cholera toxin,Ras superfamily member,involved in vesicular trafficking and activation of phospholipase D,ubiquitously expressed (highly in pancreas,pituitary gland and placenta)

Phenotypes From GWAS Catalog for ARF5 Gene

Gene Ontology (GO) - Molecular Function for ARF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity TAS 1993656
GO:0005515 protein binding IPI 17030804
GO:0005525 GTP binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with ARF5: view
genes like me logo Genes that share phenotypes with ARF5: view

Animal Models for ARF5 Gene

MGI Knock Outs for ARF5:
  • Arf5 Arf5<tm1.1Tsdk>

Animal Model Products

CRISPR Products

miRNA for ARF5 Gene

miRTarBase miRNAs that target ARF5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARF5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARF5 Gene

Localization for ARF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF5 Gene

Golgi apparatus. Cytoplasm, perinuclear region. Membrane. Lipid-anchor. Golgi apparatus, trans-Golgi network membrane. Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARF5 gene
Compartment Confidence
extracellular 4
golgi apparatus 4
plasma membrane 3
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ARF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with ARF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARF5 Gene

Pathways & Interactions for ARF5 Gene

genes like me logo Genes that share pathways with ARF5: view

Pathways by source for ARF5 Gene

1 KEGG pathway for ARF5 Gene
2 Qiagen pathways for ARF5 Gene
  • Cholera Infection
  • Paxillin Interactions

Gene Ontology (GO) - Biological Process for ARF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IGI 24768165
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IBA 21873635
genes like me logo Genes that share ontologies with ARF5: view

No data available for SIGNOR curated interactions for ARF5 Gene

Drugs & Compounds for ARF5 Gene

(1) Drugs for ARF5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARF5: view

Transcripts for ARF5 Gene

mRNA/cDNA for ARF5 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARF5

Alternative Splicing Database (ASD) splice patterns (SP) for ARF5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for ARF5 Gene

GeneLoc Exon Structure for
ARF5

Expression for ARF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARF5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARF5 Gene



Protein tissue co-expression partners for ARF5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARF5

SOURCE GeneReport for Unigene cluster for ARF5 Gene:

Hs.653202

Evidence on tissue expression from TISSUES for ARF5 Gene

  • Nervous system(4.7)
  • Skin(4.6)
  • Lung(4.5)
  • Kidney(2.6)
  • Liver(2.3)
  • Heart(2.3)
  • Pancreas(2.3)
  • Muscle(2.2)
  • Blood(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with ARF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARF5 Gene

Orthologs for ARF5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARF5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARF5 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ARF5 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ARF5 30 31
  • 95.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ARF5 30 31
  • 95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arf5 30
  • 94.26 (n)
Mouse
(Mus musculus)
Mammalia Arf5 30 17 31
  • 94.26 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ARF5 31
  • 92 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ARF5 (1 of 2) 31
  • 94 (a)
OneToMany
arf5 31
  • 93 (a)
OneToMany
zgc:77650 30
  • 76.67 (n)
-- 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1944 30
Fruit Fly
(Drosophila melanogaster)
Insecta Arf102F 31 32
  • 84 (a)
OneToMany
Arf79F 32
  • 80 (a)
Worm
(Caenorhabditis elegans)
Secernentea arf-1 32
  • 80 (a)
arf-3 30 31 32
  • 71.69 (n)
OneToMany
arl-6 32
  • 58 (a)
arl-5 32
  • 44 (a)
arl-query 32
  • 41 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 31
  • 69 (a)
ManyToMany
ARF2 31
  • 69 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 74 (a)
OneToMany
Species where no ortholog for ARF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ARF5 Gene

ENSEMBL:
Gene Tree for ARF5 (if available)
TreeFam:
Gene Tree for ARF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARF5: view image

Paralogs for ARF5 Gene

(31) SIMAP similar genes for ARF5 Gene using alignment to 3 proteins:

  • ARF5_HUMAN
  • A4D0Z3_HUMAN
  • C9J1Z8_HUMAN

Pseudogenes.org Pseudogenes for ARF5 Gene

genes like me logo Genes that share paralogs with ARF5: view

Variants for ARF5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARF5 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
787320 Benign: not provided 127,591,248(+) A/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ARF5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARF5 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV gain 17160897

Variation tolerance for ARF5 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARF5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARF5 Gene

Disorders for ARF5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARF5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
geroderma osteodysplasticum
  • go
- elite association - COSMIC cancer census association via MalaCards
Search ARF5 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ARF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARF5 Gene

Publications for ARF5 Gene

  1. Identification of a new Pyk2 target protein with Arf-GAP activity. (PMID: 10022920) Andreev J … Schlessinger J (Molecular and cellular biology 1999) 3 4 23
  2. Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene. (PMID: 9169151) McGuire RE … Green ED (Genomics 1997) 3 4 23
  3. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. (PMID: 1993656) Tsuchiya M … Vaughan M (The Journal of biological chemistry 1991) 2 3 4
  4. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PMID: 17030804) Shiba T … Wakatsuki S (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ARF5 Gene

  • Signalway Proteins for ARF5

Sources for ARF5 Gene