Aliases for ARF4 Gene
External Ids for ARF4 Gene
Previous HGNC Symbols for ARF4 Gene
Previous GeneCards Identifiers for ARF4 Gene
This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARF4 Gene
ARF4 (ADP Ribosylation Factor 4) is a Protein Coding gene. Diseases associated with ARF4 include Cholera and Chromosome 17Q21.31 Duplication Syndrome. Among its related pathways are Metabolism of proteins and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARF5.
UniProtKB/Swiss-Prot Summary for ARF4 Gene
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.