External Ids for ARF3 Gene
Previous GeneCards Identifiers for ARF3 Gene
ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARF3 Gene
ARF3 (ADP Ribosylation Factor 3) is a Protein Coding gene. Diseases associated with ARF3 include Cholera and Distal Hereditary Motor Neuropathy, Type Ii. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARF1.
UniProtKB/Swiss-Prot for ARF3 Gene
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.