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Aliases for ARF3 Gene

Aliases for ARF3 Gene

  • ADP Ribosylation Factor 3 2 3 5
  • Small GTP Binding Protein 2 3
  • ADP-Ribosylation Factor 3 3

External Ids for ARF3 Gene

Previous GeneCards Identifiers for ARF3 Gene

  • GC12M049256
  • GC12M049556
  • GC12M049046
  • GC12M047616
  • GC12M049329
  • GC12M046361
  • GC12M049299

Summaries for ARF3 Gene

Entrez Gene Summary for ARF3 Gene

  • ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARF3 Gene

ARF3 (ADP Ribosylation Factor 3) is a Protein Coding gene. Diseases associated with ARF3 include Cholera and Distal Hereditary Motor Neuropathy, Type Ii. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARF1.

UniProtKB/Swiss-Prot for ARF3 Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Gene Wiki entry for ARF3 Gene

Additional gene information for ARF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF3 Gene

Genomics for ARF3 Gene

GeneHancer (GH) Regulatory Elements for ARF3 Gene

Promoters and enhancers for ARF3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J048956 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 659.8 +0.7 733 3 HDGF PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 YY1 ARF3 ENSG00000272822 CCNT1 KANSL2 LMBR1L LOC390314 DDX23 KMT2D SENP1 PRPF40B
GH12J048937 Promoter 0.8 EPDnew 650.3 +20.5 20540 0.1 SCRT1 ZNF335 CTCF ZFHX2 IKZF1 PRDM1 EGR2 ARF3 ENSG00000255863 GC12M048929 ENSG00000272822
GH12J048939 Promoter 0.7 EPDnew 650.4 +18.5 18497 0.1 KLF17 SPI1 ENSG00000255863 ARF3 GC12M048929 ENSG00000272822
GH12J048936 Promoter 0.6 EPDnew 650.3 +21.3 21343 0.1 CTCF ARF3 ENSG00000255863 GC12M048929 ENSG00000272822
GH12J048998 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.4 -42.2 -42220 2.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 GLIS2 ZNF213 ZNF207 ZNF143 DDN DDN-AS1 KMT2D ARF3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARF3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARF3 gene promoter:
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • HNF-4alpha2
  • HNF-4alpha1
  • E2F-2
  • E2F-1
  • E2F

Genomic Locations for ARF3 Gene

Genomic Locations for ARF3 Gene
26,396 bases
Minus strand
21,829 bases
Minus strand

Genomic View for ARF3 Gene

Genes around ARF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF3 Gene

Proteins for ARF3 Gene

  • Protein details for ARF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor 3
    Protein Accession:
    Secondary Accessions:
    • A8K6G8
    • B7ZB63
    • P16587

    Protein attributes for ARF3 Gene

    181 amino acids
    Molecular mass:
    20601 Da
    Quaternary structure:
    • Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.

    Alternative splice isoforms for ARF3 Gene


neXtProt entry for ARF3 Gene

Post-translational modifications for ARF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARF3 Gene

Domains & Families for ARF3 Gene

Gene Families for ARF3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARF3 Gene

Suggested Antigen Peptide Sequences for ARF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF3: view

Function for ARF3 Gene

Molecular function for ARF3 Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
GENATLAS Biochemistry:
ADP ribosylation factor 3,class I,low molecular weight GTP binding protein,a guanine nucleotide dependent protein activator of cholera toxin,with two transcripts resulting from alternative use of polyadenylation transcripts,(20kDa),widely expressed,especially in brain,Ras superfamily member,involved in vesicular trafficking and activation of phospholipase D

Gene Ontology (GO) - Molecular Function for ARF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity TAS 1744102
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARF3: view
genes like me logo Genes that share phenotypes with ARF3: view

Animal Models for ARF3 Gene

MGI Knock Outs for ARF3:
  • Arf3 Arf3<tm1b(EUCOMM)Hmgu>

Animal Model Products

Clone Products

  • Addgene plasmids for ARF3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARF3 Gene

Localization for ARF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF3 Gene

Golgi apparatus. Cytoplasm, perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARF3 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endosome 2
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ARF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with ARF3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARF3 Gene

Pathways & Interactions for ARF3 Gene

genes like me logo Genes that share pathways with ARF3: view

Gene Ontology (GO) - Biological Process for ARF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IGI 24768165
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ARF3: view

No data available for SIGNOR curated interactions for ARF3 Gene

Drugs & Compounds for ARF3 Gene

(1) Drugs for ARF3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for ARF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARF3: view

Transcripts for ARF3 Gene

mRNA/cDNA for ARF3 Gene

(4) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARF3 Gene

ADP-ribosylation factor 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for ARF3

Alternative Splicing Database (ASD) splice patterns (SP) for ARF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - - - - - - - - -
SP7: -
SP8: - - - - - - - - - - - - - - - - - -
SP10: - -

Relevant External Links for ARF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARF3 Gene

This gene is overexpressed in Brain (24.4), Saliva (22.7), and Heart (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARF3 Gene

Protein tissue co-expression partners for ARF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARF3 Gene:


SOURCE GeneReport for Unigene cluster for ARF3 Gene:


Evidence on tissue expression from TISSUES for ARF3 Gene

  • Nervous system(5)
  • Skin(4.8)
  • Lung(4.7)
  • Kidney(3.5)
  • Intestine(3.1)
  • Pancreas(3)
  • Eye(2.8)
  • Heart(2.8)
  • Stomach(2.8)
  • Liver(2.7)
  • Muscle(2.7)
  • Adrenal gland(2.3)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with ARF3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARF3 Gene

Orthologs for ARF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ARF1 34
  • 100 (a)
ARF3 33
  • 95.58 (n)
(Pan troglodytes)
Mammalia ARF3 33
  • 100 (n)
(Bos Taurus)
Mammalia ARF3 33
  • 95.76 (n)
(Mus musculus)
Mammalia Arf3 16 34 33
  • 92.82 (n)
(Rattus norvegicus)
Mammalia Arf3 33
  • 91.71 (n)
(Anolis carolinensis)
Reptilia ARF3 34
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arf3 33
  • 83.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6539 33
(Danio rerio)
Actinopterygii arf3b 34
  • 100 (a)
arf3a 33
  • 81.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arf79F 34 35
  • 93 (a)
Arf102F 35
  • 81 (a)
(Caenorhabditis elegans)
Secernentea arf-1.2 34
  • 92 (a)
arf-1 35
  • 92 (a)
arf-3 35
  • 84 (a)
arl-6 35
  • 61 (a)
arl-5 35
  • 48 (a)
arl-query 35
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 34
  • 76 (a)
ARF2 34
  • 75 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARFA1E 33
  • 75.37 (n)
(Glycine max)
eudicotyledons Gma.11398 33
(Oryza sativa)
Liliopsida Os07g0223400 33
  • 76.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 74 (a)
Species where no ortholog for ARF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARF3 Gene

Gene Tree for ARF3 (if available)
Gene Tree for ARF3 (if available)
Evolutionary constrained regions (ECRs) for ARF3: view image

Paralogs for ARF3 Gene

(33) SIMAP similar genes for ARF3 Gene using alignment to 5 proteins:

  • B7ZB63_HUMAN
  • F5H0C7_HUMAN
  • F5H1V1_HUMAN
  • F5H6T5_HUMAN Pseudogenes for ARF3 Gene

genes like me logo Genes that share paralogs with ARF3: view

Variants for ARF3 Gene

Sequence variations from dbSNP and Humsavar for ARF3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000314829 -- 48,940,062(-) A/G coding_sequence_variant, missense_variant
rs1000418782 -- 48,931,799(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000455117 -- 48,953,427(-) A/G intron_variant
rs1000524980 -- 48,933,598(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000536951 -- 48,945,667(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARF3 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV gain 17160897

Variation tolerance for ARF3 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARF3 Gene

Disorders for ARF3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ARF3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • cholera - vibrio cholerae
distal hereditary motor neuropathy, type ii
  • dsma2
hypotrichosis 3
  • hypt3
cardiomyopathy, dilated, 1p
  • cmd1p
- elite association - COSMIC cancer census association via MalaCards
Search ARF3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARF3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARF3 Gene

Publications for ARF3 Gene

  1. Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors. (PMID: 10623590) Takeya R … Sumimoto H (Biochemical and biophysical research communications 2000) 3 4 22 58
  2. Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively. (PMID: 8661066) Hirai M … Hashimoto K (Genomics 1996) 2 3 22 58
  3. Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin. (PMID: 1744102) Tsai SC … Vaughan M (The Journal of biological chemistry 1991) 3 4 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ARF3 Gene

Sources for ARF3 Gene

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