Aliases for AREG Gene
External Ids for AREG Gene
Previous HGNC Symbols for AREG Gene
Previous GeneCards Identifiers for AREG Gene
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
GeneCards Summary for AREG Gene
AREG (Amphiregulin) is a Protein Coding gene. Diseases associated with AREG include Ovarian Cystadenoma and Colorectal Cancer. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include cytokine activity and epidermal growth factor receptor binding. An important paralog of this gene is HBEGF.
UniProtKB/Swiss-Prot Summary for AREG Gene
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.