Aliases for AREG Gene
Aliases for AREG Gene
External Ids for AREG Gene
- HGNC: 651
- Entrez Gene: 374
- Ensembl: ENSG00000109321
- OMIM: 104640
- UniProtKB: P15514
Previous HGNC Symbols for AREG Gene
- SDGF
- AREGB
Previous GeneCards Identifiers for AREG Gene
- GC04P075300
- GC04P075550
- GC04P075711
- GC04P075777
- GC04P075675
- GC04P071121
Summaries for AREG Gene
-
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
GeneCards Summary for AREG Gene
AREG (Amphiregulin) is a Protein Coding gene. Diseases associated with AREG include Colorectal Cancer and Psoriasis. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and epidermal growth factor receptor binding. An important paralog of this gene is HBEGF.
UniProtKB/Swiss-Prot for AREG Gene
-
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Additional gene information for AREG Gene
- Monarch Initiative
- Search for AREG at DataMed
- Search for AREG at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AREG Gene
Genomics for AREG Gene
GeneHancer (GH) Regulatory Elements for AREG Gene
Promoters and enhancers for AREG Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J074444 | Promoter/Enhancer | 1.2 | EPDnew Ensembl dbSUPER | 650.7 | +0.2 | 202 | 1.4 | AREG ENSG00000249942 | ||
| GH04J074097 | Promoter/Enhancer | 2.4 | EPDnew Ensembl ENCODE dbSUPER | 12.6 | -345.9 | -345909 | 4 | HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 | CXCL2 ANKRD17 ENSG00000250220 CXCL3 AREG MTHFD2L LOC643014 | |
| GH04J074363 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 5.5 | -78.5 | -78475 | 5.8 | PKNOX1 ATF1 RB1 SIN3A NFXL1 ETS1 ZNF335 POLR2B ZNF143 ZFP91 | EREG EPGN AREG ENSG00000250532 | |
| GH04J074407 | Enhancer | 1 | FANTOM5 ENCODE dbSUPER | 7 | -34.8 | -34810 | 6.5 | L3MBTL2 MAFG FOSL1 ZNF316 JUND CREB1 MAFK EMSY | AREG CXCL2 ENSG00000250532 EREG | |
| GH04J074391 | Enhancer | 0.8 | FANTOM5 ENCODE dbSUPER | 8.1 | -52.9 | -52901 | 0.9 | NFE2 | EREG CXCL2 CXCL3 AREG MTHFD2L ENSG00000250532 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around AREG on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AREG gene promoter:
-
- STAT3
- c-Jun
- ATF-2
- AP-1
- C/EBPalpha
- AML1a
- POU2F1a
Regulatory Element Products
Genomic Locations for AREG Gene
Genomic Locations for AREG Gene
- chr4:74,445,098-74,455,009
- (GRCh38/hg38)
- Size:
- 9,912 bases
- Orientation:
- Plus strand
- chr4:75,310,851-75,320,726
- (GRCh37/hg19)
- Size:
- 9,876 bases
- Orientation:
- Plus strand
Genomic View for AREG Gene
Genes around AREG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by Entrez Gene
- 4q13.3 by HGNC
- 4q13.3 by Ensembl
AREG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AREG Gene
Proteins for AREG Gene
-
Protein details for AREG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15514-AREG_HUMAN
- Recommended name:
- Amphiregulin
- Protein Accession:
- P15514
- Q5U026
Protein attributes for AREG Gene
- Size:
- 252 amino acids
- Molecular mass:
- 27895 Da
- Quaternary structure:
-
- The immature precursor interacts with CNIH.
- Miscellaneous:
-
- AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.
Protein Expression for AREG Gene
Post-translational modifications for AREG Gene
Other Protein References for AREG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for AREG (Amphiregulin)
- Novus Biologicals Antibodies for AREG
- Invitrogen Antibodies for AREG
- antibodies-online: Search results for 88 available Amphiregulin Antibodies ranked by validation data
- Compare Top Amphiregulin Antibodies
-
Recommended
- 48 WB Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 25 WB Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 5 WB Antibodies (anti-rat)
- 48 WB Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 25 WB Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 5 WB Antibodies (anti-rat)
- GeneTex AREG Antibody for AREG
-
Boster Bio Antibodies for AREG
-
Santa Cruz Biotechnology (SCBT) Antibodies for AREG
Protein Products
- R&D Systems Proteins and Enzymes for AREG (Amphiregulin)
-
OriGene Purified Proteins for AREG
- Search Origene for MassSpec and Protein Over-expression Lysates for AREG
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- ProSpec Recombinant Proteins for AREG
- GeneTex Proteins for AREG
-
ProSci Proteins for AREG
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for AREG (Amphiregulin)
- Novus Biologicals ELISA Kits for AREG
- antibodies-online: Search results for 95 available Amphiregulin Elisa Kits ranked by validation data
- Compare Top Amphiregulin Elisa Kits
-
Recommended
- 6 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 2 Goat ELISA Kits
- 4 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 20 Human ELISA Kits
- 4 Monkey ELISA Kits
- 20 Mouse (Murine) ELISA Kits
- 7 Pig (Porcine) ELISA Kits
- 7 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 6 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 2 Goat ELISA Kits
- 4 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 20 Human ELISA Kits
- 4 Monkey ELISA Kits
- 20 Mouse (Murine) ELISA Kits
- 7 Pig (Porcine) ELISA Kits
- 7 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
No data available for DME Specific Peptides for AREG Gene
Domains & Families for AREG Gene
Gene Families for AREG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted membrane proteins
Protein Domains for AREG Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AREG Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P15514- Family:
-
- Belongs to the amphiregulin family.
Function for AREG Gene
Molecular function for AREG Gene
- UniProtKB/Swiss-Prot Function:
- Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
- UniProtKB/Swiss-Prot Induction:
- By phorbol 12-myristate 13-acetate (PMA).
- GENATLAS Biochemistry:
- amphiregulin,27.9kDa,bifunctional protein possessing an epithelial cell growth regulator (EGF family) and a tumor-inhibitory activity
Phenotypes From GWAS Catalog for AREG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005154 | epidermal growth factor receptor binding | IBA,IEA | -- |
| GO:0005515 | protein binding | IPI | 19740107 |
| GO:0008083 | growth factor activity | IBA | -- |
Phenotypes for AREG Gene
- MGI mutant phenotypes for AREG:
-
inferred from 4 alleles
- cardiovascular system phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- reproductive system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for AREG:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for AREG
-
CRISPR Products
-
OriGene CRISPR knockouts for AREG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AREG
- genomics-online: gRNA clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- Applied Biological Materials CRISPR for AREG
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AREG
- GenScript: Design CRISPR guide RNA sequences for AREG
miRNA for AREG Gene
- miRTarBase miRNAs that target AREG
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for AREG
- Browse OriGene Inhibitory RNA Products For AREG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AREG
- genomics-online: shRNA clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
Clone Products
- Sino Biological Human cDNA Clone for AREG
- VectorBuilder custom plasmid, inducible vectors for AREG
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AREG
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AREG
- genomics-online: cdna clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- orf clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- Applied Biological Materials Clones for AREG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for AREG
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AREG Gene
Localization for AREG Gene
Subcellular locations from UniProtKB/Swiss-Prot for AREG Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| nucleus | 3 |
| plasma membrane | 2 |
| golgi apparatus | 2 |
| cytosol | 1 |
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005615 | extracellular space | TAS,IDA | 12743035 |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for AREG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Transport to the Golgi and subsequent modification | ||
| 5 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
Pathways by source for AREG Gene
5 BioSystems pathways for AREG Gene
9 Reactome pathways for AREG Gene
1 PharmGKB pathway for AREG Gene
5 KEGG pathways for AREG Gene
2 GeneGo (Thomson Reuters) pathways for AREG Gene
1 R&D Systems pathway for AREG Gene
Interacting Proteins for AREG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IDA,IEA | 12743035 |
| GO:0007186 | G-protein coupled receptor signaling pathway | IDA | 12743035 |
| GO:0007267 | cell-cell signaling | TAS | 2466334 |
| GO:0008283 | cell proliferation | TAS | 2466334 |
Drugs & Compounds for AREG Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cetuximab | Approved | Pharma | EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 784 | ||
| Capecitabine | Approved, Investigational | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines | 1402 | ||
| Irinotecan | Approved, Investigational | Pharma | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1181 | ||
| Panitumumab | Approved, Investigational | Pharma | EGFR inhibitor, EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 0 | ||
| radiotherapy | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for AREG Gene
mRNA/cDNA for AREG Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (90) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000395748 1240 bps (uc032tme.2)
- ENST00000502307 956 bps (uc062xhr.1)
- ENST00000511560 763 bps (uc062xhs.1)
CRISPR Products
-
OriGene CRISPR knockouts for AREG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AREG
- genomics-online: gRNA clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- Applied Biological Materials CRISPR for AREG
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AREG
- GenScript: Design CRISPR guide RNA sequences for AREG
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for AREG
- Browse OriGene Inhibitory RNA Products For AREG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AREG
- genomics-online: shRNA clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
Clone Products
- Sino Biological Human cDNA Clone for AREG
- VectorBuilder custom plasmid, inducible vectors for AREG
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AREG
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AREG
- genomics-online: cdna clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- orf clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- Applied Biological Materials Clones for AREG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for AREG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
- Spinous Keratinocytes Stratified Epidermis
- Intermediate Keratinocytes Embryonic Epidermis
- Basal Keratinocytes Embryonic Epidermis
-
Epidermis (Integumentary System)
- Spinous Keratinocytes Stratified Epidermis
- Intermediate Keratinocytes Embryonic Epidermis
- Basal Keratinocytes Embryonic Epidermis
- Blood (Hematopoietic System)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- NULL (Uncategorized)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for AREG Gene
This gene is overexpressed in Whole Blood (x7.0).
This gene is overexpressed in Liver (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AREG Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of AREG Gene:
AREGSOURCE GeneReport for Unigene cluster for AREG Gene:
Hs.270833Evidence on tissue expression from TISSUES for AREG Gene
- Nervous system(4.3)
- Lung(3.1)
- Skin(2.6)
- Intestine(2.5)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for AREG
-
OriGene qPCR primer pairs for AREG
- genomics-online: primer clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AREG Gene
Orthologs for AREG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AREG 34 33 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | LOC475176 33 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | LOC538751 33 |
|
||
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Areg 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Areg 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | AREGB 33 |
|
||
| AREG 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100145251 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | AREG 34 |
|
OneToMany |
- Species where no ortholog for AREG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for AREG Gene
- ENSEMBL:
- Gene Tree for AREG (if available)
- TreeFam:
- Gene Tree for AREG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AREG: view image
Paralogs for AREG Gene
Variants for AREG Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000042196 | -- | 74,450,284(+) | T/A | intron_variant | |
| rs1000485195 | -- | 74,445,545(+) | C/T | intron_variant | |
| rs1000658719 | -- | 74,449,688(+) | G/C | intron_variant | |
| rs1000778599 | -- | 74,447,347(+) | G/A | intron_variant | |
| rs1000835953 | -- | 74,445,904(+) | T/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv950052 | CNV | deletion | 24416366 |
| nsv525980 | CNV | gain | 19592680 |
| nsv1074187 | CNV | deletion | 25765185 |
| nsv1009099 | CNV | gain | 25217958 |
| esv2664200 | CNV | deletion | 23128226 |
| dgv2829n106 | CNV | deletion | 24896259 |
Gene Damage Index Score:
2.15;
38.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AREG Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AREG
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AREG Gene
Disorders for AREG Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
| psoriasis |
|
|
| gastritis |
|
|
| breast cancer |
|
|
| mucoepidermoid carcinoma |
|
|
Search AREG in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AREG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for AREG Gene
Publications for AREG Gene
- Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. (PMID: 1333777) Culouscou JM … Shoyab M (Growth factors (Chur, Switzerland) 1992) 3 4 22 58
- A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. (PMID: 2017164) Cook PW … Shipley GD (Molecular and cellular biology 1991) 3 4 22 58
- Clarification of the C-terminal proteolytic processing site of human Amphiregulin. (PMID: 22967896) Levano KS … Kenny PA (FEBS letters 2012) 3 4 58
- BRCA1 represses amphiregulin gene expression. (PMID: 20103632) Lamber EP … Parvin JD (Cancer research 2010) 3 22 58
- Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin. (PMID: 19609315) Stoll SW … Elder JT (The Journal of investigative dermatology 2010) 3 22 58
Products for AREG Gene
- R&D Systems Antibodies for AREG (Amphiregulin)
- R&D Systems Proteins and Enzymes for AREG (Amphiregulin)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for AREG (Amphiregulin)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Custom Assay Services
- OriGene Purified Proteins for AREG
- Search Origene for MassSpec and Protein Over-expression Lysates for AREG
- Origene Custom Protein Services for AREG
- Origene sirna, shrna, and RNAi products in human, mouse, rat for AREG
- Browse OriGene Inhibitory RNA Products For AREG
- OriGene qPCR primer pairs and template standards for AREG
- OriGene qPCR primer pairs for AREG
- OriGene CRISPR knockouts for AREG
- OriGene ORF clones in human for AREG
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AREG
- GenScript: Next-day shipping of latest version cDNA ORF clones for AREG in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AREG
- GenScript Custom Assay Services for AREG
- GenScript Custom overexpressing Cell Line Services for AREG
- GenScript: Design CRISPR guide RNA sequences for AREG
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for AREG
- Sino Biological Human cDNA Clone for AREG
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for AREG
- Novus Biologicals proteins and lysates for AREG
- Novus Biologicals ELISA Kits for AREG
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for AREG
- VectorBuilder custom plasmid, inducible vectors for AREG
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AREG
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 88 available Amphiregulin Antibodies ranked by validation data
- Compare Top Amphiregulin Antibodies
- Recommended
- 48 WB Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 25 WB Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 5 WB Antibodies (anti-rat)
- 48 WB Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 25 WB Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 5 WB Antibodies (anti-rat)
- antibodies-online: Search results for 95 available Amphiregulin Elisa Kits ranked by validation data
- Compare Top Amphiregulin Elisa Kits
- Recommended
- 6 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 2 Goat ELISA Kits
- 4 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 20 Human ELISA Kits
- 4 Monkey ELISA Kits
- 20 Mouse (Murine) ELISA Kits
- 7 Pig (Porcine) ELISA Kits
- 7 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 6 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 2 Goat ELISA Kits
- 4 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 20 Human ELISA Kits
- 4 Monkey ELISA Kits
- 20 Mouse (Murine) ELISA Kits
- 7 Pig (Porcine) ELISA Kits
- 7 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- antibodies-online: Search results for 22 available Amphiregulin Proteins ranked by validation data
- Compare Top Amphiregulin Proteins
- GeneTex AREG Antibody for AREG
- GeneTex Proteins for AREG
- Santa Cruz Biotechnology (SCBT) Antibodies for AREG
- Search Santa Cruz Biotechnology (SCBT) for AREG siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AREG
- Search for AREG Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for AREG
- Horizon Cell Lines for AREG
- genomics-online: cdna clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- orf clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- genomics-online: gRNA clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- genomics-online: primer clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- genomics-online: shRNA clones - Search results for 113 available Amphiregulin gene related products
- Overview of 113 available Amphiregulin gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AREG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AREG
- GeneCopoeia miRNA 3'UTR Target clone products for AREG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AREG
Sources for AREG Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt