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The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial c... See more...
Aliases for AREG Gene
Aliases for AREG Gene
External Ids for AREG Gene
- HGNC: 651
- NCBI Entrez Gene: 374
- Ensembl: ENSG00000109321
- OMIM®: 104640
- UniProtKB/Swiss-Prot: P15514
Previous HGNC Symbols for AREG Gene
- SDGF
- AREGB
Previous GeneCards Identifiers for AREG Gene
- GC04P075300
- GC04P075550
- GC04P075711
- GC04P075777
- GC04P075675
- GC04P071121
Summaries for AREG Gene
-
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
GeneCards Summary for AREG Gene
AREG (Amphiregulin) is a Protein Coding gene. Diseases associated with AREG include Ovarian Cystadenoma and Psoriasis. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include cytokine activity and epidermal growth factor receptor binding. An important paralog of this gene is HBEGF.
UniProtKB/Swiss-Prot Summary for AREG Gene
-
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Additional gene information for AREG Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AREG Gene
Genomics for AREG Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for AREG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around AREG on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AREG
- Top Transcription factor binding sites by QIAGEN in the AREG gene promoter:
-
- AML1a
- AP-1
- ATF-2
- c-Jun
- C/EBPalpha
- POU2F1a
- STAT3
Genomic Locations for AREG Gene
Latest Assembly
- chr4:74,445,136-74,455,005
- (GRCh38/hg38)
- Size:
- 9,870 bases
- Orientation:
- Plus strand
Previous Assembly
- chr4:75,310,853-75,320,722
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 9,870 bases
- Orientation:
- Plus strand
Genomic View for AREG Gene
Genes around AREG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by HGNC
- 4q13.3 by Entrez Gene
- 4q13.3 by Ensembl
AREG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AREG Gene
Proteins for AREG Gene
-
Protein details for AREG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15514-AREG_HUMAN
- Recommended name:
- Amphiregulin
- Protein Accession:
- P15514
- Q5U026
Protein attributes for AREG Gene
- Size:
- 252 amino acids
- Molecular mass:
- 27895 Da
- Quaternary structure:
-
- The immature precursor interacts with CNIH.
- Miscellaneous:
-
- AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.
Protein Expression for AREG Gene
Post-translational modifications for AREG Gene
Other Protein References for AREG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences AREG / Amphiregulin Antibody
- G Biosciences Immunotag™ AREG Antibody
- GeneTex Anti-Amphiregulin antibody
- Novus Biologicals Antibodies for AREG
-
Abcam antibodies for AREG
- Invitrogen Antibodies for AREG (AFLGC-AREG)
-
Custom Antibody ServicesProSci Antibodies for AREG
-
Santa Cruz Biotechnology (SCBT) Antibodies for AREG
- Sino Biological Antibodies for AREG
Protein products for research
- G Biosciences Human SDGF/Amphiregulin/AREG/AREGB/CRDGF/AR, Lyophilized
- RayBiotech Recombinant Human AR
- Search Origene for MassSpec and Protein Over-expression Lysates for AREG
- Origene Custom Protein Services for AREG
- ProSpec Recombinant Proteins for AREG
-
ProSci Proteins for AREG
-
Abcam proteins for AREG
Assay products for research
- G Biosciences Immunotag™ Amphiregulin ELISA Kit
- RayBiotech Human Amphiregulin ELISA
- Novus Biologicals ELISA Kits for AREG
- antibodies-online: Show 111 available Amphiregulin Elisa Kits ranked by validation data
- Compare Top Amphiregulin Elisa Kits
-
Quality Products:
- ABIN6720551
- ABIN6720525
- ABIN624943
- ABIN414351
- ABIN1113368
- ABIN2683490
- ABIN1889290
- ABIN365786
- ABIN491735
- ABIN3032886
- ABIN1115708
- ABIN625111
- ABIN415356
- ABIN2859282
- ABIN3032795
- ABIN1568494
- ABIN6719952
- ABIN2683491
- ABIN5669692
- ABIN1081212
- ABIN416298
- ABIN1081213
- ABIN368145
- ABIN1568496
- ABIN1115709
- ABIN5670353
- ABIN626689
- ABIN772008
- ABIN5651687
- ABIN5651688
- ABIN413966
- ABIN1568490
- ABIN1081215
- ABIN5651680
- ABIN5651679
- ABIN988854
- ABIN2541213
- ABIN2943897
-
Abcam assays for AREG
No data available for DME Specific Peptides for AREG Gene
Domains & Families for AREG Gene
Gene Families for AREG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted membrane proteins
Protein Domains for AREG Gene
- InterPro:
- Blocks:
-
- Type I EGF
Suggested Antigen Peptide Sequences for AREG Gene
- GenScript: Design optimal peptide antigens:
-
- Colorectum cell-derived growth factor (AREG_HUMAN)
- Amphiregulin (Schwannoma-derived growth factor) (Q5U026_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15514- Family:
-
- Belongs to the amphiregulin family.
Function for AREG Gene
Molecular function for AREG Gene
- UniProtKB/Swiss-Prot Function:
- Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
- UniProtKB/Swiss-Prot Induction:
- By phorbol 12-myristate 13-acetate (PMA).
- GENATLAS Biochemistry:
- amphiregulin,27.9kDa,bifunctional protein possessing an epithelial cell growth regulator (EGF family) and a tumor-inhibitory activity
Phenotypes From GWAS Catalog for AREG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005154 | epidermal growth factor receptor binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 19740107 |
| GO:0008083 | growth factor activity | IEA,IBA | 21873635 |
Phenotypes for AREG Gene
- MGI mutant phenotypes for AREG:
-
inferred from 4 alleles
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- immune system phenotype
- mortality/aging
- hematopoietic system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- GenomeRNAi human phenotypes for AREG:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for AREG - Starting at $85 >
- * AREG CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for AREG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AREG
-
Santa Cruz Biotechnology (SCBT) CRISPR for AREG
miRNA for AREG Gene
- miRTarBase miRNAs that target AREG
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AREG
- Browse OriGene Inhibitory RNA Products For AREG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AREG
Clone products for research
- Applied Biological Materials (abm): Clones for AREG - Starting at $45 >
- * AREG as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for AREG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AREG
Cell Lines for research
-
Horizon Cell Lines for AREG
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AREG Gene
Localization for AREG Gene
Subcellular locations from UniProtKB/Swiss-Prot for AREG Gene
- Membrane. Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| golgi apparatus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 12743035 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for AREG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Transport to the Golgi and subsequent modification | ||
| 5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
Pathways by source for AREG Gene
5 BioSystems pathways for AREG Gene
9 Reactome pathways for AREG Gene
1 PharmGKB pathway for AREG Gene
5 KEGG pathways for AREG Gene
2 GeneGo (Thomson Reuters) pathways for AREG Gene
- Development EGFR signaling pathway
- Development ERBB-family signaling
1 R&D Systems pathway for AREG Gene
55 Qiagen pathways for AREG Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
Interacting Proteins for AREG Gene
Selected Interacting proteins:
P15514-AREG_HUMAN
ENSP00000379097
for AREG Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for AREG
SIGNOR curated interactions for AREG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0007165 | signal transduction | TAS | -- |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IEA,TAS | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IDA | 12743035 |
Drugs & Compounds for AREG Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cetuximab | Approved | Pharma | EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 902 | ||
| Capecitabine | Approved, Investigational | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines | 1763 | ||
| Irinotecan | Approved, Investigational | Pharma | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1504 | ||
| Panitumumab | Approved, Investigational | Pharma | EGFR inhibitor, EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 246 | ||
| radiotherapy | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human SDGF/Amphiregulin/AREG/AREGB/CRDGF/AR, Lyophilized
- RayBiotech Recombinant Human AR
Transcripts for AREG Gene
mRNA/cDNA for AREG Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000395748 1234 nts (view in UCSC)
- ENST00000502307 956 nts (view in UCSC)
- ENST00000511560 763 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for AREG - Starting at $85 >
- * AREG CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for AREG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AREG
-
Santa Cruz Biotechnology (SCBT) CRISPR for AREG
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AREG
- Browse OriGene Inhibitory RNA Products For AREG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AREG
Clone products for research
- Applied Biological Materials (abm): Clones for AREG - Starting at $45 >
- * AREG as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for AREG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AREG
Relevant External Links for AREG Gene
- GeneLoc Exon Structure for
- AREG
Expression for AREG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
- Spinous Keratinocytes Stratified Epidermis
- Intermediate Keratinocytes Embryonic Epidermis
- Basal Keratinocytes Embryonic Epidermis
-
Epidermis (Integumentary System)
- Spinous Keratinocytes Stratified Epidermis
- Intermediate Keratinocytes Embryonic Epidermis
- Basal Keratinocytes Embryonic Epidermis
- Blood (Hematopoietic System)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- NULL (Uncategorized)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for AREG Gene
This gene is overexpressed in Whole Blood (x7.0).
This gene is overexpressed in Liver (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AREG Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AREG
SOURCE GeneReport for Unigene cluster for AREG Gene:
Hs.270833Evidence on tissue expression from TISSUES for AREG Gene
- Nervous system(4.4)
- Lung(2.8)
- Heart(2.7)
- Muscle(2.6)
- Spleen(2.6)
- Intestine(2.5)
- Liver(2.3)
- Blood(2.3)
- Skin(2.2)
- Lymph node(2)
Primer products for research
-
OriGene qPCR primer pairs for AREG
-
OriGene qPCR primer pairs and template standards for AREG
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AREG Gene
Orthologs for AREG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | AREG 29 30 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | LOC475176 29 |
|
||
| -- 30 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | LOC538751 29 |
|
||
| -- 30 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Areg 29 16 30 |
|
OneToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Areg 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | AREGB 29 |
|
||
| AREG 30 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100145251 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | AREG 30 |
|
OneToMany |
- Species where no ortholog for AREG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for AREG Gene
- ENSEMBL:
- Gene Tree for AREG (if available)
- TreeFam:
- Gene Tree for AREG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AREG: view image
- Alliance of Genome Resources:
- Additional Orthologs for AREG
Paralogs for AREG Gene
Variants for AREG Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AREG Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs201209086 | Benign: not provided | 74,446,570(+) |
A/G NM_001657.4(AREG):c.98A>G (p.Tyr33Cys) |
MISSENSE | |
| rs28364979 | -- |
p.Tyr81Cys |
|||
| rs373527160 | -- |
p.Asp80Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2829n106 | CNV | deletion | 24896259 |
| esv2664200 | CNV | deletion | 23128226 |
| nsv1009099 | CNV | gain | 25217958 |
| nsv1074187 | CNV | deletion | 25765185 |
| nsv525980 | CNV | gain | 19592680 |
| nsv950052 | CNV | deletion | 24416366 |
Gene Damage Index Score:
2.15;
38.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AREG Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AREG Gene
Disorders for AREG Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian cystadenoma |
|
|
| psoriasis |
|
|
| colorectal cancer |
|
|
| breast cancer |
|
|
| gastritis |
|
|
Search AREG in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AREG
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for AREG Gene
Publications for AREG Gene
- Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. (PMID: 1333777) Culouscou JM … Shoyab M (Growth factors (Chur, Switzerland) 1992) 3 4 22
- A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. (PMID: 2017164) Cook PW … Shipley GD (Molecular and cellular biology 1991) 3 4 22
- The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. (PMID: 2325643) Plowman GD … Shoyab M (Molecular and cellular biology 1990) 3 4 22
- Clarification of the C-terminal proteolytic processing site of human Amphiregulin. (PMID: 22967896) Levano KS … Kenny PA (FEBS letters 2012) 3 4
- BRCA1 represses amphiregulin gene expression. (PMID: 20103632) Lamber EP … Parvin JD (Cancer research 2010) 3 22
ExternalLinks
Products for AREG Gene
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Abcam antibodies for AREG
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- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for AREG (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for AREG (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for AREG (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for AREG CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for AREG
- antibodies-online: Show 18 available Amphiregulin Antibodies ranked by validation data
- Compare Top Amphiregulin Antibodies
- antibodies-online: Show 111 available Amphiregulin Elisa Kits ranked by validation data
- Compare Top Amphiregulin Elisa Kits
- Quality Products:
- ABIN6720551
- ABIN6720525
- ABIN624943
- ABIN414351
- ABIN1113368
- ABIN2683490
- ABIN1889290
- ABIN365786
- ABIN491735
- ABIN3032886
- ABIN1115708
- ABIN625111
- ABIN415356
- ABIN2859282
- ABIN3032795
- ABIN1568494
- ABIN6719952
- ABIN2683491
- ABIN5669692
- ABIN1081212
- ABIN416298
- ABIN1081213
- ABIN368145
- ABIN1568496
- ABIN1115709
- ABIN5670353
- ABIN626689
- ABIN772008
- ABIN5651687
- ABIN5651688
- ABIN413966
- ABIN1568490
- ABIN1081215
- ABIN5651680
- ABIN5651679
- ABIN988854
- ABIN2541213
- ABIN2943897
- antibodies-online: Show 28 available Amphiregulin Proteins ranked by validation data
- Compare Top Amphiregulin Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for AREG
- Search Santa Cruz Biotechnology (SCBT) for AREG siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AREG
- Custom Antibody ServicesProSci Antibodies for AREG
- ProSci Proteins for AREG
- Horizon Cell Lines for AREG
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AREG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AREG
- Search GeneCopoeia for miRNA 3'UTR Target clone products for AREG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AREG
Sources for AREG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources