Aliases for ARAP3 Gene
External Ids for ARAP3 Gene
Previous HGNC Symbols for ARAP3 Gene
Previous GeneCards Identifiers for ARAP3 Gene
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]
GeneCards Summary for ARAP3 Gene
ARAP3 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity and Class I PI3K signaling events. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of this gene is ARAP2.
UniProtKB/Swiss-Prot Summary for ARAP3 Gene
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.