This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this g... See more...

Aliases for ARAP3 Gene

Aliases for ARAP3 Gene

  • ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3 2 3 5
  • Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 3 3 4
  • Centaurin-Delta-3 3 4
  • CENTD3 3 4
  • ARF-GAP, RHO-GAP, Ankyrin Repeat And Plekstrin Homology Domains-Containing Protein 3 3
  • Arf And Rho GAP Adapter Protein 3 3
  • Phosphoinositide Binding Protein 3
  • PtdIns(3,4,5)P3-Binding Protein 3
  • Centaurin, Delta 3 2
  • Cnt-D3 4
  • DRAG1 3

External Ids for ARAP3 Gene

Previous HGNC Symbols for ARAP3 Gene

  • CENTD3

Previous GeneCards Identifiers for ARAP3 Gene

  • GC05M140849
  • GC05M141615
  • GC05M141016
  • GC05M141061
  • GC05M141013
  • GC05M136177
  • GC05M141032

Summaries for ARAP3 Gene

Entrez Gene Summary for ARAP3 Gene

  • This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]

GeneCards Summary for ARAP3 Gene

ARAP3 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity and Class I PI3K signaling events. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of this gene is ARAP2.

UniProtKB/Swiss-Prot Summary for ARAP3 Gene

  • Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.

Gene Wiki entry for ARAP3 Gene

Additional gene information for ARAP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARAP3 Gene

Genomics for ARAP3 Gene

GeneHancer (GH) Regulatory Elements for ARAP3 Gene

Promoters and enhancers for ARAP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARAP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARAP3 gene promoter:
  • AhR
  • Arnt
  • C/EBPalpha
  • CUTL1
  • Lhx3a
  • LHX3b
  • MyoD
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ARAP3 Gene

Genomic Locations for ARAP3 Gene
chr5:141,653,401-141,682,233
(GRCh38/hg38)
Size:
28,833 bases
Orientation:
Minus strand
chr5:141,032,968-141,061,800
(GRCh37/hg19)
Size:
28,833 bases
Orientation:
Minus strand

Genomic View for ARAP3 Gene

Genes around ARAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAP3 Gene

Proteins for ARAP3 Gene

  • Protein details for ARAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWN8-ARAP3_HUMAN
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
    Protein Accession:
    Q8WWN8
    Secondary Accessions:
    • B4DIT1
    • D3DQE3

    Protein attributes for ARAP3 Gene

    Size:
    1544 amino acids
    Molecular mass:
    169844 Da
    Quaternary structure:
    • Interacts (via SAM domain) with INPPL1/SHIP2.

    Three dimensional structures from OCA and Proteopedia for ARAP3 Gene

    Alternative splice isoforms for ARAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARAP3 Gene

Post-translational modifications for ARAP3 Gene

  • Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation is increased in cells that are in the process of becoming attached to a substrate and that start spreading and flattening (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARAP3 Gene

Domains & Families for ARAP3 Gene

Suggested Antigen Peptide Sequences for ARAP3 Gene

GenScript: Design optimal peptide antigens:
  • Centaurin-delta-3 (ARAP3_HUMAN)
  • cDNA FLJ58150, highly similar to Centaurin-delta 3 (B4DIT1_HUMAN)
  • ARAP3 protein (Q05CA7_HUMAN)
  • ARAP3 protein (Q96G49_HUMAN)
genes like me logo Genes that share domains with ARAP3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARAP3 Gene

Function for ARAP3 Gene

Molecular function for ARAP3 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.

Phenotypes From GWAS Catalog for ARAP3 Gene

Gene Ontology (GO) - Molecular Function for ARAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 NOT GTPase activator activity ISS,IEA --
GO:0005515 protein binding IEA,IPI 15090612
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11804589
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 11804589
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARAP3: view
genes like me logo Genes that share phenotypes with ARAP3: view

Animal Models for ARAP3 Gene

MGI Knock Outs for ARAP3:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for ARAP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ARAP3 Gene

Localization for ARAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARAP3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell projection, ruffle. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARAP3 gene
Compartment Confidence
cytosol 5
plasma membrane 3
cytoskeleton 3
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for ARAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ARAP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARAP3 Gene

Pathways & Interactions for ARAP3 Gene

genes like me logo Genes that share pathways with ARAP3: view

Pathways by source for ARAP3 Gene

Gene Ontology (GO) - Biological Process for ARAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization TAS 15569923
GO:0007165 signal transduction IEA --
GO:0016192 vesicle-mediated transport TAS 15569923
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARAP3: view

No data available for SIGNOR curated interactions for ARAP3 Gene

Drugs & Compounds for ARAP3 Gene

(1) Additional Compounds for ARAP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARAP3: view

Transcripts for ARAP3 Gene

mRNA/cDNA for ARAP3 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for ARAP3

Alternative Splicing Database (ASD) splice patterns (SP) for ARAP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1: - -
SP2:
SP3:
SP4: - - -
SP5: - -
SP6:
SP7: -
SP8: -
SP9: - -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ARAP3 Gene

GeneLoc Exon Structure for
ARAP3
ECgene alternative splicing isoforms for
ARAP3

Expression for ARAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARAP3 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for ARAP3 Gene

This gene is overexpressed in Lavage (35.5) and Serum (30.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARAP3 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARAP3 Gene:

ARAP3

SOURCE GeneReport for Unigene cluster for ARAP3 Gene:

Hs.726187

Evidence on tissue expression from TISSUES for ARAP3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ARAP3: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARAP3 Gene

Orthologs for ARAP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARAP3 33 32
  • 99.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARAP3 33 32
  • 90.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARAP3 33 32
  • 89.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arap3 17 33 32
  • 86.81 (n)
rat
(Rattus norvegicus)
Mammalia Arap3 32
  • 85.92 (n)
oppossum
(Monodelphis domestica)
Mammalia ARAP3 33
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARAP3 33
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARAP3 33 32
  • 65.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARAP3 33
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arap3 32
  • 59.65 (n)
Str.16223 32
zebrafish
(Danio rerio)
Actinopterygii arap3 33 32
  • 58.15 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP15B 33 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F23H11.4 33
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 33
  • 20 (a)
OneToMany
Species where no ortholog for ARAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARAP3 Gene

ENSEMBL:
Gene Tree for ARAP3 (if available)
TreeFam:
Gene Tree for ARAP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARAP3: view image

Paralogs for ARAP3 Gene

(6) SIMAP similar genes for ARAP3 Gene using alignment to 6 proteins:

  • ARAP3_HUMAN
  • B4DIT1_HUMAN
  • G5E9Y3_HUMAN
  • Q05CA7_HUMAN
  • Q05CH1_HUMAN
  • Q96G49_HUMAN
genes like me logo Genes that share paralogs with ARAP3: view

Variants for ARAP3 Gene

Sequence variations from dbSNP and Humsavar for ARAP3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs145752053 uncertain-significance, Malignant tumor of prostate 141,662,250(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs61749636 A breast cancer sample 141,654,303(-) T/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
VAR_036180 A colorectal cancer sample p.Arg471Trp
VAR_036181 A breast cancer sample p.Ile1085Met
rs539283748 uncertain-significance, not provided 141,656,261(-) G/A/C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ARAP3 Gene

Variant ID Type Subtype PubMed ID
esv2730848 CNV deletion 23290073
esv3606989 CNV loss 21293372
nsv1109732 CNV deletion 24896259
nsv1154058 CNV deletion 26484159
nsv472203 CNV novel sequence insertion 20440878
nsv5034 CNV insertion 18451855

Variation tolerance for ARAP3 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARAP3 Gene

Human Gene Mutation Database (HGMD)
ARAP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARAP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARAP3 Gene

Disorders for ARAP3 Gene

Additional Disease Information for ARAP3

No disorders were found for ARAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARAP3 Gene

Publications for ARAP3 Gene

  1. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. (PMID: 11804589) Krugmann S … Hawkins PT (Molecular cell 2002) 2 3 4 23 56
  2. EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin. (PMID: 15569923) Lu Q … Cohen SN (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23 56
  3. GTPase signaling: bridging the GAP between ARF and Rho. (PMID: 12015138) Santy LC … Casanova JE (Current biology : CB 2002) 2 3 4 56
  4. The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner. (PMID: 17314030) Raaijmakers JH … Bos JL (Cellular signalling 2007) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for ARAP3 Gene

Sources for ARAP3 Gene