Aliases for ARAP3 Gene
External Ids for ARAP3 Gene
Previous HGNC Symbols for ARAP3 Gene
Previous GeneCards Identifiers for ARAP3 Gene
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]
GeneCards Summary for ARAP3 Gene
ARAP3 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3) is a Protein Coding gene. Diseases associated with ARAP3 include Oropharyngeal Anthrax and Gastrointestinal Anthrax. Among its related pathways are Signaling by GPCR and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of this gene is ARAP2.
UniProtKB/Swiss-Prot Summary for ARAP3 Gene
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.