Aliases for ARAP2 Gene
External Ids for ARAP2 Gene
Previous HGNC Symbols for ARAP2 Gene
Previous GeneCards Identifiers for ARAP2 Gene
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
GeneCards Summary for ARAP2 Gene
ARAP2 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Diseases associated with ARAP2 include Loiasis and Type 1 Diabetes Mellitus 8. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ARAP1.
UniProtKB/Swiss-Prot Summary for ARAP2 Gene
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).