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Aliases for ARAP2 Gene

Aliases for ARAP2 Gene

  • ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2 2 3 5
  • Centaurin-Delta-1 3 4
  • CENTD1 3 4
  • Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 2 3
  • Arf And Rho GAP Adapter Protein 2 3
  • Centaurin, Delta 1 2
  • Protein PARX 4
  • KIAA0580 4
  • Cnt-D1 4
  • PARX 3

External Ids for ARAP2 Gene

Previous HGNC Symbols for ARAP2 Gene

  • CENTD1

Previous GeneCards Identifiers for ARAP2 Gene

  • GC04M035744
  • GC04M036067
  • GC04M035394

Summaries for ARAP2 Gene

Entrez Gene Summary for ARAP2 Gene

  • The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

GeneCards Summary for ARAP2 Gene

ARAP2 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ARAP3.

UniProtKB/Swiss-Prot for ARAP2 Gene

  • Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

Gene Wiki entry for ARAP2 Gene

Additional gene information for ARAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAP2 Gene

Genomics for ARAP2 Gene

GeneHancer (GH) Regulatory Elements for ARAP2 Gene

Promoters and enhancers for ARAP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J036240 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 656.2 +1.3 1345 5.4 PKNOX1 FOXA2 ZFP64 FEZF1 YY1 GLIS2 KLF7 FOS RUNX3 SP3 LOC439933 ARAP2 LOC651644
GH04J036254 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 654.6 -11.3 -11312 2.7 BMI1 BATF IRF4 YY1 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM ARAP2 LOC439933 DTHD1
GH04J036641 Promoter 0.8 EPDnew 650.1 -397.4 -397419 0.1 E2F1 POLR2A EGR1 NFRKB LINC02505 ARAP2 GC04M036977
GH04J036073 Promoter 0.5 EPDnew 650.1 +170.7 170654 0.1 ARAP2 LOC651644 LOC439933
GH04J036280 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.4 -39.5 -39479 6.8 PKNOX1 SMAD1 STAT5A BMI1 BATF IRF4 ATF7 FOS ETV6 BCLAF1 DTHD1 LOC439933 ARAP2 LOC105374399
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARAP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARAP2 gene promoter:
  • Evi-1
  • aMEF-2
  • RORalpha2
  • RSRFC4
  • MEF-2A
  • MEF-2
  • POU2F1a
  • POU2F1
  • Meis-1
  • AML1a

Genomic Locations for ARAP2 Gene

Genomic Locations for ARAP2 Gene
chr4:35,948,221-36,244,509
(GRCh38/hg38)
Size:
296,289 bases
Orientation:
Minus strand
chr4:35,949,843-36,246,131
(GRCh37/hg19)
Size:
296,289 bases
Orientation:
Minus strand

Genomic View for ARAP2 Gene

Genes around ARAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAP2 Gene

Proteins for ARAP2 Gene

  • Protein details for ARAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ64-ARAP2_HUMAN
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q8WZ64
    Secondary Accessions:
    • Q4W5D2
    • Q7Z2L5
    • Q96L70
    • Q96P49
    • Q9Y4E4

    Protein attributes for ARAP2 Gene

    Size:
    1704 amino acids
    Molecular mass:
    193452 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL04166.1; Type=Frameshift; Positions=1579; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARAP2 Gene

neXtProt entry for ARAP2 Gene

Post-translational modifications for ARAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARAP2 Gene

No data available for DME Specific Peptides for ARAP2 Gene

Domains & Families for ARAP2 Gene

Suggested Antigen Peptide Sequences for ARAP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARAP2: view

No data available for UniProtKB/Swiss-Prot for ARAP2 Gene

Function for ARAP2 Gene

Molecular function for ARAP2 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

Phenotypes From GWAS Catalog for ARAP2 Gene

Gene Ontology (GO) - Molecular Function for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IEA --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA,IDA 11804589
GO:0031267 small GTPase binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARAP2: view
genes like me logo Genes that share phenotypes with ARAP2: view

Animal Models for ARAP2 Gene

MGI Knock Outs for ARAP2:
  • Arap2 Arap2<tm2b(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARAP2 Gene

Localization for ARAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARAP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARAP2 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IBA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with ARAP2: view

Pathways & Interactions for ARAP2 Gene

genes like me logo Genes that share pathways with ARAP2: view

Pathways by source for ARAP2 Gene

1 GeneTex pathway for ARAP2 Gene
1 BioSystems pathway for ARAP2 Gene
1 KEGG pathway for ARAP2 Gene

Gene Ontology (GO) - Biological Process for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0016192 vesicle-mediated transport IBA --
GO:0032012 regulation of ARF protein signal transduction IBA --
GO:0035023 regulation of Rho protein signal transduction IBA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARAP2: view

No data available for SIGNOR curated interactions for ARAP2 Gene

Drugs & Compounds for ARAP2 Gene

(1) Drugs for ARAP2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with ARAP2: view

Transcripts for ARAP2 Gene

Unigene Clusters for ARAP2 Gene

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARAP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: -
SP2: -
SP3:
SP4: - - -
SP5:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ARAP2 Gene

GeneLoc Exon Structure for
ARAP2
ECgene alternative splicing isoforms for
ARAP2

Expression for ARAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARAP2 Gene

This gene is overexpressed in Prostate (41.5), Bone marrow mesenchymal stem cell (17.3), and Cervix (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARAP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARAP2 Gene:

ARAP2

SOURCE GeneReport for Unigene cluster for ARAP2 Gene:

Hs.479451

mRNA Expression by UniProt/SwissProt for ARAP2 Gene:

Q8WZ64-ARAP2_HUMAN
Tissue specificity: Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ARAP2 Gene

  • Nervous system(4.3)
  • Stomach(3.7)
  • Blood(2)
genes like me logo Genes that share expression patterns with ARAP2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARAP2 Gene

Orthologs for ARAP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARAP2 34 33
  • 99.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARAP2 34 33
  • 89.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARAP2 34 33
  • 89.16 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arap2 33
  • 84.46 (n)
mouse
(Mus musculus)
Mammalia Arap2 16 34 33
  • 84.24 (n)
oppossum
(Monodelphis domestica)
Mammalia ARAP2 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARAP2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARAP2 34 33
  • 68.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARAP2 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arap2 33
  • 61.18 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559690 33
  • 56.2 (n)
ARAP2 34
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP15B 34
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F23H11.4 34
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 34
  • 22 (a)
OneToMany
Species where no ortholog for ARAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARAP2 Gene

ENSEMBL:
Gene Tree for ARAP2 (if available)
TreeFam:
Gene Tree for ARAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARAP2: view image

Paralogs for ARAP2 Gene

Paralogs for ARAP2 Gene

(3) SIMAP similar genes for ARAP2 Gene using alignment to 5 proteins:

  • ARAP2_HUMAN
  • A7E2A5_HUMAN
  • D6RAD6_HUMAN
  • D6RC39_HUMAN
  • Q2M2Z8_HUMAN
genes like me logo Genes that share paralogs with ARAP2: view

Variants for ARAP2 Gene

Sequence variations from dbSNP and Humsavar for ARAP2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000010698 -- 36,184,295(-) A/ATACA genic_upstream_transcript_variant, intron_variant
rs1000013071 -- 36,231,729(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000016546 -- 36,013,927(-) G/A genic_downstream_transcript_variant, intron_variant
rs10000381 -- 36,092,481(-) T/C intron_variant
rs1000065299 -- 36,216,554(-) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARAP2 Gene

Variant ID Type Subtype PubMed ID
nsv829907 CNV gain 17160897
nsv829906 CNV gain 17160897
nsv829905 CNV gain 17160897
nsv593982 CNV loss 21841781
nsv509889 OTHER sequence alteration 20534489
nsv461332 CNV loss 19166990
nsv4300 CNV deletion 18451855
esv3600220 CNV gain 21293372
esv3600219 CNV loss 21293372
esv3600218 CNV loss 21293372
esv3600217 CNV loss 21293372
esv3569373 CNV loss 25503493

Variation tolerance for ARAP2 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARAP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARAP2 Gene

Disorders for ARAP2 Gene

Additional Disease Information for ARAP2

No disorders were found for ARAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARAP2 Gene

Publications for ARAP2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. ARAP1: a point of convergence for Arf and Rho signaling. (PMID: 11804590) Miura K … Randazzo PA (Molecular cell 2002) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai DC … Hagoort P (Genes, brain, and behavior 2014) 3 58

Products for ARAP2 Gene

Sources for ARAP2 Gene

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