The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and fu... See more...

Aliases for ARAP2 Gene

Aliases for ARAP2 Gene

  • ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2 2 3 5
  • Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 2 3 4
  • Centaurin-Delta-1 3 4
  • CENTD1 3 4
  • Arf And Rho GAP Adapter Protein 2 3
  • Centaurin, Delta 1 2
  • Protein PARX 4
  • KIAA0580 4
  • Cnt-D1 4
  • PARX 3

External Ids for ARAP2 Gene

Previous HGNC Symbols for ARAP2 Gene

  • CENTD1

Previous GeneCards Identifiers for ARAP2 Gene

  • GC04M035744
  • GC04M036067
  • GC04M035394

Summaries for ARAP2 Gene

Entrez Gene Summary for ARAP2 Gene

  • The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

GeneCards Summary for ARAP2 Gene

ARAP2 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Diseases associated with ARAP2 include Loiasis and Type 1 Diabetes Mellitus 8. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ARAP1.

UniProtKB/Swiss-Prot Summary for ARAP2 Gene

  • Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

Gene Wiki entry for ARAP2 Gene

Additional gene information for ARAP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARAP2 Gene

Genomics for ARAP2 Gene

GeneHancer (GH) Regulatory Elements for ARAP2 Gene

Promoters and enhancers for ARAP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J036240 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 506.1 +1.4 1350 5.4 POLR2G ZFX CTCF ZNF10 ZIC2 POLR2A ZBTB26 KLF7 MEF2C RCOR1 LOC439933 ARAP2 lnc-RELL1-8
GH04J036254 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 504.6 -11.3 -11307 2.7 RELA BCL11A TCF12 POLR2A SMC3 SRF TARDBP ARNT MEF2B CHD1 ARAP2 LOC439933 DTHD1 piR-38351-331
GH04J036641 Promoter 0.6 EPDnew 500 -397.4 -397414 0.1 NFRKB TFDP1 POLR2A EGR1 E2F1 LINC02505 ARAP2 piR-32688-010
GH04J036073 Promoter 0.3 EPDnew 500.1 +170.7 170659 0.1 lnc-ARAP2-1 ARAP2 lnc-RELL1-6
GH04J036280 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.4 -39.7 -39691 7.2 SP1 EP300 JUND RELA MEF2C RCOR1 REST TRIM22 BCL11A TCF12 DTHD1 LOC439933 ARAP2 LOC105374399
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARAP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARAP2

Top Transcription factor binding sites by QIAGEN in the ARAP2 gene promoter:
  • aMEF-2
  • AML1a
  • Evi-1
  • MEF-2
  • MEF-2A
  • Meis-1
  • POU2F1
  • POU2F1a
  • RORalpha2
  • RSRFC4

Genomic Locations for ARAP2 Gene

Genomic Locations for ARAP2 Gene
chr4:35,948,221-36,244,514
(GRCh38/hg38)
Size:
296,294 bases
Orientation:
Minus strand
chr4:35,949,843-36,246,131
(GRCh37/hg19)
Size:
296,289 bases
Orientation:
Minus strand

Genomic View for ARAP2 Gene

Genes around ARAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAP2 Gene

Proteins for ARAP2 Gene

  • Protein details for ARAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ64-ARAP2_HUMAN
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q8WZ64
    Secondary Accessions:
    • Q4W5D2
    • Q7Z2L5
    • Q96L70
    • Q96P49
    • Q9Y4E4

    Protein attributes for ARAP2 Gene

    Size:
    1704 amino acids
    Molecular mass:
    193452 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL04166.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARAP2 Gene

neXtProt entry for ARAP2 Gene

Post-translational modifications for ARAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARAP2 Gene

No data available for DME Specific Peptides for ARAP2 Gene

Domains & Families for ARAP2 Gene

Protein Domains for ARAP2 Gene

Blocks:
  • RhoGAP domain
  • Pleckstrin-like
  • HIV Rev interacting protein signature
  • RA domain
  • Sterile alpha motif SAM
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARAP2 Gene

GenScript: Design optimal peptide antigens:
  • ARAP2 protein (A7E2A5_HUMAN)
  • Protein PARX (ARAP2_HUMAN)
  • ARAP2 protein (Q2M2Z8_HUMAN)
genes like me logo Genes that share domains with ARAP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARAP2 Gene

Function for ARAP2 Gene

Molecular function for ARAP2 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

Phenotypes From GWAS Catalog for ARAP2 Gene

Gene Ontology (GO) - Molecular Function for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA,IEA 11804589
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARAP2: view
genes like me logo Genes that share phenotypes with ARAP2: view

Animal Models for ARAP2 Gene

MGI Knock Outs for ARAP2:
  • Arap2 Arap2<tm2b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARAP2 Gene

Localization for ARAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARAP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARAP2 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARAP2: view

Pathways & Interactions for ARAP2 Gene

genes like me logo Genes that share pathways with ARAP2: view

Pathways by source for ARAP2 Gene

1 BioSystems pathway for ARAP2 Gene
1 KEGG pathway for ARAP2 Gene
1 GeneTex pathway for ARAP2 Gene

Gene Ontology (GO) - Biological Process for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARAP2: view

No data available for SIGNOR curated interactions for ARAP2 Gene

Drugs & Compounds for ARAP2 Gene

(1) Drugs for ARAP2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with ARAP2: view

Transcripts for ARAP2 Gene

mRNA/cDNA for ARAP2 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARAP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: -
SP2: -
SP3:
SP4: - - -
SP5:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ARAP2 Gene

GeneLoc Exon Structure for
ARAP2

Expression for ARAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARAP2 Gene

This gene is overexpressed in Prostate (41.5), Bone marrow mesenchymal stem cell (17.3), and Cervix (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARAP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARAP2

SOURCE GeneReport for Unigene cluster for ARAP2 Gene:

Hs.479451

mRNA Expression by UniProt/SwissProt for ARAP2 Gene:

Q8WZ64-ARAP2_HUMAN
Tissue specificity: Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ARAP2 Gene

  • Nervous system(4.3)
  • Stomach(3.7)
  • Blood(2)
genes like me logo Genes that share expression patterns with ARAP2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARAP2 Gene

Orthologs for ARAP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARAP2 31 30
  • 99.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARAP2 31 30
  • 89.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARAP2 31 30
  • 89.16 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arap2 30
  • 84.46 (n)
mouse
(Mus musculus)
Mammalia Arap2 17 31 30
  • 84.24 (n)
oppossum
(Monodelphis domestica)
Mammalia ARAP2 31
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARAP2 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARAP2 31 30
  • 68.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARAP2 31
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arap2 30
  • 61.18 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559690 30
  • 56.2 (n)
ARAP2 31
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP15B 31
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F23H11.4 31
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 31
  • 22 (a)
OneToMany
Species where no ortholog for ARAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARAP2 Gene

ENSEMBL:
Gene Tree for ARAP2 (if available)
TreeFam:
Gene Tree for ARAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARAP2: view image

Paralogs for ARAP2 Gene

(3) SIMAP similar genes for ARAP2 Gene using alignment to 5 proteins:

  • ARAP2_HUMAN
  • A7E2A5_HUMAN
  • D6RAD6_HUMAN
  • D6RC39_HUMAN
  • Q2M2Z8_HUMAN
genes like me logo Genes that share paralogs with ARAP2: view

Variants for ARAP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARAP2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs35218548 - p.Phe1006Leu
rs35468501 - p.Lys384Asn
rs4833069 - p.Arg1523Gln

Additional dbSNP identifiers (rs#s) for ARAP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARAP2 Gene

Variant ID Type Subtype PubMed ID
esv3569373 CNV loss 25503493
esv3600217 CNV loss 21293372
esv3600218 CNV loss 21293372
esv3600219 CNV loss 21293372
esv3600220 CNV gain 21293372
nsv4300 CNV deletion 18451855
nsv461332 CNV loss 19166990
nsv509889 OTHER sequence alteration 20534489
nsv593982 CNV loss 21841781
nsv829905 CNV gain 17160897
nsv829906 CNV gain 17160897
nsv829907 CNV gain 17160897

Variation tolerance for ARAP2 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARAP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARAP2 Gene

Disorders for ARAP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARAP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
loiasis
  • african eye worm
type 1 diabetes mellitus 8
  • diabetes mellitus, insulin-dependent, 8
- elite association - COSMIC cancer census association via MalaCards
Search ARAP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARAP2

genes like me logo Genes that share disorders with ARAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARAP2 Gene

Publications for ARAP2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  2. ARAP1: a point of convergence for Arf and Rho signaling. (PMID: 11804590) Miura K … Randazzo PA (Molecular cell 2002) 3 4 54
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 54
  4. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3 54
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54

Products for ARAP2 Gene

Sources for ARAP2 Gene