ARAF Gene (Protein Coding)

A-Raf Proto-Oncogene, Serine/Threonine Kinase

GC0XP047562
GIFtS:
45
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012] See more...

Aliases for ARAF Gene

Aliases for ARAF Gene

  • A-Raf Proto-Oncogene, Serine/Threonine Kinase 2 3 5
  • V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog 1 2 3
  • Serine/Threonine-Protein Kinase A-Raf 3 4
  • Proto-Oncogene A-Raf-1 3 4
  • Proto-Oncogene Pks 3 4
  • EC 2.7.11.1 4 51
  • ARAF1 3 4
  • PKS2 3 4
  • V-Raf Murine Sarcoma 3611 Viral Oncogene-Like Protein 3
  • A-Raf Proto-Oncogene Serine/Threonine-Protein Kinase 3
  • Ras-Binding Protein DA-Raf 3
  • Proto-Oncogene A-Raf 4
  • Oncogene ARAF1 3
  • EC 2.7.11 51
  • A-RAF 3
  • RAFA1 3
  • ARAF 5
  • PKS 4

External Ids for ARAF Gene

Previous HGNC Symbols for ARAF Gene

  • ARAF1

Previous GeneCards Identifiers for ARAF Gene

  • GC0XP047177
  • GC0XP047305
  • GC0XP047429
  • GC0XP045132

Summaries for ARAF Gene

Entrez Gene Summary for ARAF Gene

  • This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

CIViC Summary for ARAF Gene

  • ARAF has recently become increasingly considered for its oncogenic potential. Its potential as a target for informing clinical action was demonstrated by a single case of advanced lung adenocarcinoma harboring an S214C mutation that, when treated with sorafenib, acheived near-complete clinical remission. This finding has brought new focus on ARAF as a marker that should be assayed for in cancer treatment.

GeneCards Summary for ARAF Gene

ARAF (A-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ARAF include Pallister-Killian Syndrome and Mycobacterium Marinum. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Negative regulation of MAPK pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RAF1.

UniProtKB/Swiss-Prot Summary for ARAF Gene

  • Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
  • [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Tocris Summary for ARAF Gene

  • Raf kinases, a family of three serine/threonine kinases, are part of the Ras-MAPK signaling cascade and phosphorylate MEK. Upon growth factor stimulation, Raf-1 (c-Raf) is activated by GTP-bound Ras and recruited to the cell membrane. This activation process is tightly regulated.

Gene Wiki entry for ARAF Gene

Additional gene information for ARAF Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARAF Gene

Genomics for ARAF Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ARAF Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ047559 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 609.3 +1.3 1329 5.4 SP1 CREB1 CTCF ATF7 TEAD4 PRDM10 ZNF629 RFX1 SIX5 IKZF1 ARAF CFP CDK16 lnc-SYN1-4 TIMP1
GH0XJ047128 Promoter/Enhancer 1.6 EPDnew ENCODE CraniofacialAtlas 11 -431.6 -431590 1.7 SP1 CREB1 ZNF692 POLR2A FOS DDX20 ZNF143 PKNOX1 PATZ1 NR2C1 RBM10 LOC107985720 LOC105373193 lnc-NDUFB11-2 INE1 ENSG00000224072 ZNF81 ZNF182 UBA1 NUS1P1
GH0XJ047555 Promoter/Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas 5.5 -4.6 -4611 1.7 SP1 CREB1 POLR2A FOS PRDM1 DDX20 ZIC2 PKNOX1 PATZ1 ZNF501 ARAF RF00017-8401 lnc-SYN1-4 ZNF41
GH0XJ047632 Enhancer 1.1 FANTOM5 ENCODE 6.9 +72.8 72826 3.2 ZNF629 POLR2A RELA ZIC2 ZSCAN4 IKZF2 TRIM22 PKNOX1 EED YBX1 CFP ARAF UXT-AS1 lnc-ELK1-1 ELK1
GH0XJ047578 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE 4.9 +18.3 18285 2 ZNF740 ZNF792 CEBPB ZKSCAN8 ZNF316 FOS MAFK MAX EP300 PRDM1 CFP ARAF JA662188 TIMP1 lnc-ARAF-1 SYN1 ENSG00000283743
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARAF on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARAF

Top Transcription factor binding sites by QIAGEN in the ARAF gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • CREB
  • deltaCREB
  • Elk-1
  • NF-kappaB1
  • Sox9

Genomic Locations for ARAF Gene

Genomic Locations for ARAF Gene
chrX:47,561,100-47,571,921
(GRCh38/hg38)
Size:
10,822 bases
Orientation:
Plus strand
chrX:47,420,516-47,431,320
(GRCh37/hg19)
Size:
10,805 bases
Orientation:
Plus strand

Genomic View for ARAF Gene

Genes around ARAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAF Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ARAF Gene

Proteins for ARAF Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ARAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10398-ARAF_HUMAN
    Recommended name:
    Serine/threonine-protein kinase A-Raf
    Protein Accession:
    P10398
    Secondary Accessions:
    • P07557
    • Q5H9B2
    • Q5H9B3

    Protein attributes for ARAF Gene

    Size:
    606 amino acids
    Molecular mass:
    67585 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with TH1L/NELFD.
    Miscellaneous:
    • [Isoform 2]: Has a wider tissue distribution than isoform 1, and acts as dominant-negative antagonist.

    Three dimensional structures from OCA and Proteopedia for ARAF Gene

    Alternative splice isoforms for ARAF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARAF Gene

Protein Expression for ARAF Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ARAF Gene

P10398:
  • GSVLWMA
  • NILLFMG
  • FHQHCSS
  • RDQIIFMVGRGYLSPDLSK
  • NPYSFQSDVYA
  • TVKIGDFGLATVK
  • TQWCEGSSLY
  • RSASEPSL
  • RKTFFSL
  • HNFVRKTF
  • ARQTAQGMDYLHAK
  • ERPLFPQIL
  • LPNKQRTVV
  • WHGDVAVK
  • GFRCQTCGYKFH
  • KSNNIFLH

Post-translational modifications for ARAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARAF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ARAF

Domains & Families for ARAF Gene

Gene Families for ARAF Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARAF Gene

InterPro:
Blocks:
  • Protein kinase C, phorbol ester/diacylglycerol binding
  • Raf-like Ras-binding
ProtoNet:

Suggested Antigen Peptide Sequences for ARAF Gene

GenScript: Design optimal peptide antigens:
  • Proto-oncogene Pks (ARAF_HUMAN)
  • cDNA FLJ59256, highly similar to A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (B4DMG5_HUMAN)
  • V-raf murine sarcoma 3611 viral oncogene homolog (Q5H9B2_HUMAN)
  • ARAF protein (Q96II5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10398

UniProtKB/Swiss-Prot:

ARAF_HUMAN :
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
genes like me logo Genes that share domains with ARAF: view

Function for ARAF Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ARAF Gene

UniProtKB/Swiss-Prot Function:
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for ARAF Gene

Gene Ontology (GO) - Molecular Function for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 3029685
GO:0004674 protein serine/threonine kinase activity IEA,IDA 19667065
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0005515 protein binding IPI 11909642
genes like me logo Genes that share ontologies with ARAF: view
genes like me logo Genes that share phenotypes with ARAF: view

Animal Models for ARAF Gene

MGI Knock Outs for ARAF:

Animal Model Products

CRISPR Products

miRNA for ARAF Gene

miRTarBase miRNAs that target ARAF

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARAF

Clone Products

  • Addgene plasmids for ARAF

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARAF Gene

Localization for ARAF Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARAF gene
Compartment Confidence
mitochondrion 4
cytosol 4
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA,IBA 21873635
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with ARAF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARAF Gene

Pathways & Interactions for ARAF Gene

PathCards logo

SuperPathways for ARAF Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
IL-21 Signaling Pathways
.90
IL-7 Signaling Pathways
.90
IL-9 Signaling Pathways
.90
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.90
IL-15 Signaling Pathways
.88
IL-2 Signaling Pathways
.88
IL-4 Signaling Pathways
.84
Adipocytokines and Insulin Signaling
.34
3 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
ErbB2-ErbB3 Heterodimers
.49
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
IL-4 Pathway
.34
4 Endometrial cancer
Colorectal cancer
.50
Endometrial cancer
.50
Pancreatic cancer
.46
Chronic myeloid leukemia
.45
Prostate cancer
.32
Acute myeloid leukemia
.30
5 Glioma
Glioma
.49
Non-small cell lung cancer
.49
Melanoma
.46
Signaling Pathways in Glioblastoma
.32
Endocrine resistance
.31
genes like me logo Genes that share pathways with ARAF: view

Pathways by source for ARAF Gene

1 Sino Biological pathway for ARAF Gene
3 GeneGo (Thomson Reuters) pathways for ARAF Gene
  • G-protein signaling M-RAS regulation pathway
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling_K-RAS regulation pathway
3 Tocris pathways for ARAF Gene
48 Qiagen pathways for ARAF Gene
  • Aldosterone Signaling in Epithelial Cells
  • Alpha-Adrenergic Signaling
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
  • EGF Pathway
1 Cell Signaling Technology pathway for ARAF Gene

SIGNOR curated interactions for ARAF Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA,TAS --
GO:0000186 activation of MAPKK activity IEA --
GO:0006464 cellular protein modification process TAS 3029685
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ARAF: view

Drugs & Compounds for ARAF Gene

Products:

  1. Drug

(31) Drugs for ARAF Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 779
alpha-D-Fucopyranose Experimental Pharma Target 0
Alpha-L-Arabinose Experimental Pharma Target 0
beta-D-fucose Experimental Pharma Target 0

(28) Additional Compounds for ARAF Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(4) Tocris Compounds for ARAF Gene

Compound Action Cas Number
GW 5074 Potent, selective c-Raf1 kinase inhibitor 220904-83-6
KG 5 PDGFRbeta, B-Raf, c-Raf, FLT3 and KIT inhibitor 877874-85-6
Kobe 0065 H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling 436133-68-5
ZM 336372 Potent, selective c-Raf inhibitor 208260-29-1

(5) ApexBio Compounds for ARAF Gene

Compound Action Cas Number
AZ 628 Raf kinases,potent and ATP-competitive 878739-06-1
CEP-32496 BRAF(V600E)inhibitor,highly potent 1188910-76-0
GDC-0879 B-Raf inhibitor,potent and selective 905281-76-7
LGX818 RAF inhibitor,potent and selective 1269440-17-6
TAK-632 Pan-RAF inhibitor,potent and selective 1228591-30-7
genes like me logo Genes that share compounds with ARAF: view

Drug Products

Transcripts for ARAF Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ARAF Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARAF

Clone Products

  • Addgene plasmids for ARAF

Alternative Splicing Database (ASD) splice patterns (SP) for ARAF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: -

ExUns: 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARAF Gene

GeneLoc Exon Structure for
ARAF

Expression for ARAF Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARAF Gene

mRNA expression in normal human tissues for ARAF Gene
mRNA expression by GTEx for ARAF GenemRNA expression by BioGPS for ARAF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Colon (Gastrointestinal Tract)

Protein differential expression in normal tissues from HIPED for ARAF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARAF Gene



Protein tissue co-expression partners for ARAF Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARAF

SOURCE GeneReport for Unigene cluster for ARAF Gene:

Hs.446641

mRNA Expression by UniProt/SwissProt for ARAF Gene:

P10398-ARAF_HUMAN
Tissue specificity: Predominantly in urogenital tissues.

Evidence on tissue expression from TISSUES for ARAF Gene

  • Kidney(4.6)
  • Liver(4.6)
  • Nervous system(4.5)
  • Muscle(3.5)
  • Intestine(3.4)
  • Lung(3.2)
  • Blood(3)
  • Skin(3)
  • Thyroid gland(2.7)
  • Heart(2.7)
  • Lymph node(2.5)
  • Bone marrow(2.5)
  • Spleen(2.5)
  • Adrenal gland(2.4)
  • Stomach(2.4)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with ARAF: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARAF Gene

Orthologs for ARAF Gene

This gene was present in the common ancestor of animals.

Orthologs for ARAF Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ARAF 31
  • 100 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ARAF 30 31
  • 93.95 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ARAF 30 31
  • 92.9 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Araf 30
  • 90.62 (n)
Mouse
(Mus musculus)
 Mammalia Araf 30 17 31
  • 90.29 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ARAF 31
  • 69 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia ARAF 31
  • 68 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ARAF 31
  • 63 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii araf 30 31
  • 65.62 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta phl 31
  • 35 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea lin-45 31
  • 30 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.10630 31
  • 36 (a)
 OneToMany
Species where no ortholog for ARAF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ARAF Gene

ENSEMBL:
Gene Tree for ARAF (if available)
TreeFam:
Gene Tree for ARAF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARAF: view image

Paralogs for ARAF Gene

Paralogs for ARAF Gene

(4) SIMAP similar genes for ARAF Gene using alignment to 3 proteins:

  • ARAF_HUMAN
  • B4DMG5_HUMAN
  • Q96II5_HUMAN

Pseudogenes.org Pseudogenes for ARAF Gene

genes like me logo Genes that share paralogs with ARAF: view

Variants for ARAF Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARAF Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
713393 Benign: not provided 47,569,651(+) G/A SYNONYMOUS_VARIANT
747628 Benign: not provided 47,571,370(+) G/C MISSENSE_VARIANT
789251 Benign: not provided 47,567,358(+) C/T SYNONYMOUS_VARIANT
rs1057519786 Likely Pathogenic: Lung adenocarcinoma; Non-small cell lung cancer; Papillary renal cell carcinoma, sporadic; Malignant melanoma of skin. Likely Pathogenic: Lung adenocarcinoma; Papillary renal cell carcinoma, sporadic; Malignant melanoma of skin 47,566,722(+) C/GC/T MISSENSE_VARIANT
rs1057519876 Likely Pathogenic: Lung adenocarcinoma; Papillary renal cell carcinoma, sporadic; Malignant melanoma of skin 47,566,721(+) T/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ARAF Gene

Variation tolerance for ARAF Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARAF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARAF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARAF Gene

Disorders for ARAF Gene

MalaCards: The human disease database

(18) MalaCards diseases for ARAF Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pallister-killian syndrome
  • pks
mycobacterium marinum
  • fish tank granuloma
adenocarcinoma
  • adenocarcinomas
langerhans cell histiocytosis
  • letterer-siwe disease
histiocytosis
  • chronic histiocytosis x
- elite association - COSMIC cancer census association via MalaCards
Search ARAF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARAF

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ARAF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARAF Gene

Publications for ARAF Gene

  1. Identification of TH1 as an interaction partner of A-Raf kinase. (PMID: 11952167) Yin XL … Gu JX (Molecular and cellular biochemistry 2002) 3 4 23
  2. The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1). (PMID: 8020955) Lee JE … Rapp UR (Genomics 1994) 3 4 23
  3. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. (PMID: 22609986) Gan X … Wu D (Nature cell biology 2012) 3 4
  4. Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. (PMID: 20145135) Rauch J … Gires O (Cancer research 2010) 3 23
  5. DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. (PMID: 17535970) Yokoyama T … Endo T (The Journal of cell biology 2007) 3 4

ExternalLinks

View latest publications for ARAF gene in Mastermind

Products for ARAF Gene