External Ids for AQP8 Gene
Previous GeneCards Identifiers for AQP8 Gene
Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008]
GeneCards Summary for AQP8 Gene
AQP8 (Aquaporin 8) is a Protein Coding gene. Diseases associated with AQP8 include Polyhydramnios. Among its related pathways are Cellular Senescence (REACTOME) and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and glycerol channel activity. An important paralog of this gene is AQP5.
UniProtKB/Swiss-Prot Summary for AQP8 Gene
Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.
Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.