This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008] See more...

Aliases for AQP10 Gene

Aliases for AQP10 Gene

  • Aquaporin 10 2 3 5
  • Small Intestine Aquaporin 3 4
  • Aquaglyceroporin-10 3 4
  • Aquaporin-10 3 4
  • AQP-10 3 4
  • AQPA_HUMAN 3
  • AQP10 5

External Ids for AQP10 Gene

Previous GeneCards Identifiers for AQP10 Gene

  • GC01P152110
  • GC01P150024
  • GC01P151068
  • GC01P151510
  • GC01P151106
  • GC01P152560
  • GC01P154294
  • GC01P125657

Summaries for AQP10 Gene

Entrez Gene Summary for AQP10 Gene

  • This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]

GeneCards Summary for AQP10 Gene

AQP10 (Aquaporin 10) is a Protein Coding gene. Diseases associated with AQP10 include Pompholyx and Fox-Fordyce Disease. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and glycerol channel activity. An important paralog of this gene is AQP9.

UniProtKB/Swiss-Prot Summary for AQP10 Gene

  • [Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH (PubMed:12084581, PubMed:21733844, PubMed:23382902, PubMed:30420639). The channel is permeable to glycerol, especially when the cytosolic pH is acidified (PubMed:21733844, PubMed:30420639). Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation (PubMed:23382902). May contribute to water transport in the intestine (Probable).
  • [Isoform 2]: Water channel that mediates water transport across cell membranes, but that is not permeable to glycerol.

Tocris Summary for AQP10 Gene

  • Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

Additional gene information for AQP10 Gene

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AQP10 Gene

Genomics for AQP10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AQP10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J154320 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 606.7 +0.4 397 1.8 GATAD2A ZNF512 RFX1 LEF1 IKZF1 JUND PRDM1 MTA2 PKNOX1 ZNF24 AQP10 L13708-001 NUP210L ADAR ATP8B2 RAB13
GH01J154403 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11 +85.8 85788 6.9 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 RFX1 IL6R IL6R-AS1 ATP8B2 RNU7-57P AQP10 UBE2Q1-AS1 UBE2Q1 SHE TDRD10 SNORA58B
GH01J154324 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +6.1 6074 5.7 HNRNPL GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 IKZF1 ZNF692 JUND ATP8B2 MN308991 CLK2 FLAD1 PYGO2 UBAP2L CHTOP ENSG00000272654 LOC101928120 SLC27A3
GH01J154312 Enhancer 0.9 dbSUPER 0.4 -8.1 -8132 1.5 ARHGAP35 ZNF512 IKZF1 JUND PRDM1 MTA2 MTA1 DPF2 HDAC1 SOX6 ENSG00000278694 UBE2Q1 S100A4 RNU7-57P SNORA58B UBAP2L ILF2 CHTOP DCST1 MIR190B
GH01J154307 Enhancer 0.6 Ensembl 0.4 -13.0 -12958 0.2 DPF2 HMBOX1 ZBTB2 ZNF316 MAFG CUX1 NR2F1 ZNF384 HDAC2 ATF3 RNU7-57P SNORA58B UBAP2L MIR190B TPM3 C1orf189 UBE2Q1 UBE2Q1-AS1 ADAR ATP8B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AQP10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AQP10

Top Transcription factor binding sites by QIAGEN in the AQP10 gene promoter:
  • c-Ets-1
  • CBF(2)
  • GR
  • GR-alpha
  • GR-beta
  • NF-Y
  • Pax-4a
  • Pax-5
  • Sox9
  • Spz1

Genomic Locations for AQP10 Gene

Genomic Locations for AQP10 Gene
chr1:154,321,059-154,325,325
(GRCh38/hg38)
Size:
4,267 bases
Orientation:
Plus strand
chr1:154,293,566-154,297,801
(GRCh37/hg19)
Size:
4,236 bases
Orientation:
Plus strand

Genomic View for AQP10 Gene

Genes around AQP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AQP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AQP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AQP10 Gene

Proteins for AQP10 Gene

  • Protein details for AQP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PS8-AQP10_HUMAN
    Recommended name:
    Aquaporin-10
    Protein Accession:
    Q96PS8
    Secondary Accessions:
    • Q5VYD3
    • Q5VYD4
    • Q8NG70

    Protein attributes for AQP10 Gene

    Size:
    301 amino acids
    Molecular mass:
    31763 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for AQP10 Gene

    Alternative splice isoforms for AQP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AQP10 Gene

Post-translational modifications for AQP10 Gene

  • Glycosylation at Asn128 and Asn133

Other Protein References for AQP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AQP10 Gene

Domains & Families for AQP10 Gene

Gene Families for AQP10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for AQP10 Gene

InterPro:
Blocks:
  • MIP family
ProtoNet:

Suggested Antigen Peptide Sequences for AQP10 Gene

GenScript: Design optimal peptide antigens:
  • Small intestine aquaporin (AQP10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96PS8

UniProtKB/Swiss-Prot:

AQP10_HUMAN :
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
  • Belongs to the MIP/aquaporin (TC 1.A.8) family.
Domain:
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Family:
  • Belongs to the MIP/aquaporin (TC 1.A.8) family.
genes like me logo Genes that share domains with AQP10: view

Function for AQP10 Gene

Molecular function for AQP10 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH (PubMed:12084581, PubMed:21733844, PubMed:23382902, PubMed:30420639). The channel is permeable to glycerol, especially when the cytosolic pH is acidified (PubMed:21733844, PubMed:30420639). Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation (PubMed:23382902). May contribute to water transport in the intestine (Probable).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Water channel that mediates water transport across cell membranes, but that is not permeable to glycerol.

Phenotypes From GWAS Catalog for AQP10 Gene

Gene Ontology (GO) - Molecular Function for AQP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015204 urea transmembrane transporter activity IBA 21873635
GO:0015250 water channel activity IDA 30420639
GO:0015254 glycerol channel activity IDA 30420639
GO:0015267 channel activity IEA --
genes like me logo Genes that share ontologies with AQP10: view
genes like me logo Genes that share phenotypes with AQP10: view

Animal Model Products

CRISPR Products

miRNA for AQP10 Gene

miRTarBase miRNAs that target AQP10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AQP10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AQP10 Gene

Localization for AQP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AQP10 Gene

Apical cell membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Lipid droplet. Note=Detected around lipid droplets. {ECO:0000269 PubMed:23382902}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AQP10 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
  • Nuclear bodies (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AQP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005811 lipid droplet IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 30420639
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AQP10: view

Pathways & Interactions for AQP10 Gene

genes like me logo Genes that share pathways with AQP10: view

Pathways by source for AQP10 Gene

1 Qiagen pathway for AQP10 Gene
  • eNOS Signaling

Gene Ontology (GO) - Biological Process for AQP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006833 water transport TAS --
GO:0009636 response to toxic substance IDA 17575980
GO:0015793 glycerol transport IDA 30420639
GO:0051289 protein homotetramerization IDA 30420639
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with AQP10: view

No data available for SIGNOR curated interactions for AQP10 Gene

Drugs & Compounds for AQP10 Gene

(2) Drugs for AQP10 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Hg<sup>2+</sup> Pharma Inhibitor 0
genes like me logo Genes that share compounds with AQP10: view

Transcripts for AQP10 Gene

mRNA/cDNA for AQP10 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AQP10

Alternative Splicing Database (ASD) splice patterns (SP) for AQP10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2:

Relevant External Links for AQP10 Gene

GeneLoc Exon Structure for
AQP10

Expression for AQP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AQP10 Gene

mRNA differential expression in normal tissues according to GTEx for AQP10 Gene

This gene is overexpressed in Whole Blood (x31.6) and Small Intestine - Terminal Ileum (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AQP10

SOURCE GeneReport for Unigene cluster for AQP10 Gene:

Hs.259048

mRNA Expression by UniProt/SwissProt for AQP10 Gene:

Q96PS8-AQP10_HUMAN
Tissue specificity: Detected in epithelial cells on villi in the ileum, and also in stomach, jejunum, colon, rectum, white adipose tissue and placenta (at protein level) (PubMed:15221416, PubMed:23382902). Expressed in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum (PubMed:11573934, PubMed:12084581). Detected in subcutaneous adipose tissue (PubMed:23382902).

Evidence on tissue expression from TISSUES for AQP10 Gene

  • Intestine(4.6)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with AQP10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AQP10 Gene

Orthologs for AQP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AQP10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AQP10 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AQP10 30
  • 88.14 (n)
Cow
(Bos Taurus)
Mammalia AQP10 30 31
  • 85.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC686596 30
  • 84.42 (n)
Oppossum
(Monodelphis domestica)
Mammalia AQP10 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 46 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves AQP10 30 31
  • 67.88 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia AQP10 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490571 30
  • 62.17 (n)
Zebrafish
(Danio rerio)
Actinopterygii aqp10b 31
  • 45 (a)
OneToMany
aqp10a 31
  • 44 (a)
OneToMany
wufj98f09 30
Worm
(Caenorhabditis elegans)
Secernentea aqp-2 30 31
  • 49.45 (n)
ManyToMany
Y69E1A.7 32
  • 40 (a)
M02F4.8 32
  • 35 (a)
aqp-8 31
  • 34 (a)
ManyToMany
aqp-1 31
  • 33 (a)
ManyToMany
aqp-7 31
  • 33 (a)
ManyToMany
aqp-3 31
  • 24 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 13 (a)
OneToMany
Species where no ortholog for AQP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for AQP10 Gene

ENSEMBL:
Gene Tree for AQP10 (if available)
TreeFam:
Gene Tree for AQP10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AQP10: view image

Paralogs for AQP10 Gene

(5) SIMAP similar genes for AQP10 Gene using alignment to 1 proteins:

  • AQP10_HUMAN

Pseudogenes.org Pseudogenes for AQP10 Gene

genes like me logo Genes that share paralogs with AQP10: view

Variants for AQP10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AQP10 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
777751 Benign: not provided 154,321,270(+) A/G INTRON_VARIANT
rs6668968 - p.Arg15Gln
rs6685323 - p.His123Tyr

Additional dbSNP identifiers (rs#s) for AQP10 Gene

Structural Variations from Database of Genomic Variants (DGV) for AQP10 Gene

Variant ID Type Subtype PubMed ID
nsv1078973 CNV deletion 25765185
nsv1142782 CNV deletion 24896259
nsv521887 CNV gain 19592680
nsv523934 CNV loss 19592680
nsv946406 CNV duplication 23825009

Variation tolerance for AQP10 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.60; 94.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AQP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AQP10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AQP10 Gene

Disorders for AQP10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for AQP10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pompholyx
  • cheiropompholyx
fox-fordyce disease
  • fox fordyce disease
diabetes insipidus, nephrogenic, autosomal
  • diabetes insipidus, nephrogenic, type ii
- elite association - COSMIC cancer census association via MalaCards
Search AQP10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AQP10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AQP10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AQP10 Gene

Publications for AQP10 Gene

  1. Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum. (PMID: 11573934) Hatakeyama S … Yamamoto T (Biochemical and biophysical research communications 2001) 2 3 4 23
  2. Human adipose glycerol flux is regulated by a pH gate in AQP10. (PMID: 30420639) Gotfryd K … Gourdon P (Nature communications 2018) 3 4
  3. Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes. (PMID: 23382902) Laforenza U … Gastaldi G (PloS one 2013) 3 4
  4. Glycosylation increases the thermostability of human aquaporin 10 protein. (PMID: 21733844) Öberg F … Hedfalk K (The Journal of biological chemistry 2011) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

Products for AQP10 Gene

Sources for AQP10 Gene