This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008] See more...

Aliases for APOL6 Gene

Aliases for APOL6 Gene

  • Apolipoprotein L6 2 3 4 5
  • Apolipoprotein L-VI 3 4
  • Apolipoprotein L, 6 3
  • APOL-VI 3
  • ApoL-VI 4
  • APOLVI 3

External Ids for APOL6 Gene

Previous GeneCards Identifiers for APOL6 Gene

  • GC22P032687
  • GC22P034316
  • GC22P034368
  • GC22P036044
  • GC22P019006

Summaries for APOL6 Gene

Entrez Gene Summary for APOL6 Gene

  • This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL6 Gene

APOL6 (Apolipoprotein L6) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is APOL3.

UniProtKB/Swiss-Prot Summary for APOL6 Gene

  • May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Gene Wiki entry for APOL6 Gene

Additional gene information for APOL6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APOL6 Gene

Genomics for APOL6 Gene

GeneHancer (GH) Regulatory Elements for APOL6 Gene

Promoters and enhancers for APOL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J035646 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 770.2 +0.1 78 4.3 SP1 ZBTB40 FOXA1 RBPJ MIXL1 ETV6 HLF L3MBTL2 RAD21 ZNF121 APOL6 lnc-MB-9 APOL5
GH22J035620 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.1 -26.5 -26521 3.4 CTCF NR2F6 CC2D1A RAD21 SP1 SP7 RFX1 RXRA REST TRIM22 APOL6 RASD2 RBFOX2 ENSG00000268818 MB HSALNG0135169
GH22J035834 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11 +189.2 189166 7.9 ZNF785 CTCF POLR2A CTBP1 CREB1 ZNF362 ZNF701 HLF RAD21 SP1 RBFOX2 RPL41P3 piR-35054-006 HMGXB4 IFT27 EIF3D MCM5 APOL6 MB RPS15AP38
GH22J035601 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 18 -42.6 -42594 7.7 ZNF785 SMARCE1 SREBF1 SMARCA4 ZNF384 ZIC2 POLR2A ZSCAN4 CEBPB CHD2 APOL6 MB RASD2 HMGXB4 TOM1 HMOX1 HSALNG0135169 ENSG00000268818
GH22J035642 Enhancer 1.1 Ensembl ENCODE dbSUPER 17.3 -6.4 -6360 2.4 FOXA1 RBPJ RAD21 ELF3 SP1 ZNF680 ZNF644 RXRA GATAD2A RXRB APOL6 FOXRED2 MB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APOL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the APOL6 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • MyoD

Genomic Locations for APOL6 Gene

Genomic Locations for APOL6 Gene
chr22:35,648,360-35,668,409
(GRCh38/hg38)
Size:
20,050 bases
Orientation:
Plus strand
chr22:36,044,424-36,064,456
(GRCh37/hg19)
Size:
20,033 bases
Orientation:
Plus strand

Genomic View for APOL6 Gene

Genes around APOL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL6 Gene

Proteins for APOL6 Gene

  • Protein details for APOL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWW8-APOL6_HUMAN
    Recommended name:
    Apolipoprotein L6
    Protein Accession:
    Q9BWW8
    Secondary Accessions:
    • Q5R3S1
    • Q658J1
    • Q8IXX6
    • Q9UGG1

    Protein attributes for APOL6 Gene

    Size:
    343 amino acids
    Molecular mass:
    38128 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOL6 Gene

Post-translational modifications for APOL6 Gene

  • Ubiquitination at Lys220 and Lys231
  • Modification sites at PhosphoSitePlus

Other Protein References for APOL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOL6 Gene

Domains & Families for APOL6 Gene

Gene Families for APOL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for APOL6 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOL6 Gene

GenScript: Design optimal peptide antigens:
  • Apolipoprotein L-VI (APOL6_HUMAN)
  • cDNA FLJ38562 fis, clone HCHON2004002, highly similar to Apolipoprotein-L6 (B3KTP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BWW8

UniProtKB/Swiss-Prot:

APOL6_HUMAN :
  • Belongs to the apolipoprotein L family.
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL6: view

Function for APOL6 Gene

Molecular function for APOL6 Gene

UniProtKB/Swiss-Prot Function:
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Phenotypes From GWAS Catalog for APOL6 Gene

Gene Ontology (GO) - Molecular Function for APOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IBA 21873635
genes like me logo Genes that share ontologies with APOL6: view
genes like me logo Genes that share phenotypes with APOL6: view

Animal Model Products

CRISPR Products

miRNA for APOL6 Gene

miRTarBase miRNAs that target APOL6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOL6 Gene

Localization for APOL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOL6 gene
Compartment Confidence
plasma membrane 2
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for APOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APOL6: view

Pathways & Interactions for APOL6 Gene

genes like me logo Genes that share pathways with APOL6: view

Pathways by source for APOL6 Gene

Interacting Proteins for APOL6 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000386280 Q9BWW8-APOL6_HUMAN for APOL6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for APOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL6: view

No data available for SIGNOR curated interactions for APOL6 Gene

Drugs & Compounds for APOL6 Gene

No Compound Related Data Available

Transcripts for APOL6 Gene

mRNA/cDNA for APOL6 Gene

(1) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(217) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOL6 Gene

No ASD Table

Relevant External Links for APOL6 Gene

GeneLoc Exon Structure for
APOL6
ECgene alternative splicing isoforms for
APOL6

Expression for APOL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for APOL6 Gene

This gene is overexpressed in Liver (48.5), Platelet (10.7), and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOL6 Gene



Protein tissue co-expression partners for APOL6 Gene

NURSA nuclear receptor signaling pathways regulating expression of APOL6 Gene:

APOL6

SOURCE GeneReport for Unigene cluster for APOL6 Gene:

Hs.257352

mRNA Expression by UniProt/SwissProt for APOL6 Gene:

Q9BWW8-APOL6_HUMAN
Tissue specificity: Widely expressed; highly expressed in the uterus, fetal brain and spinal cord, also detected in heart, liver, lung, colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and mammary gland.

Evidence on tissue expression from TISSUES for APOL6 Gene

  • Lymph node(4.2)
  • Liver(2.3)
genes like me logo Genes that share expression patterns with APOL6: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOL6 Gene

Orthologs for APOL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOL6 33 32
  • 98.93 (n)
OneToOne
cow
(Bos Taurus)
Mammalia APOL6 33 32
  • 71.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia APOL6 33 32
  • 68.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Apol6 17 33 32
  • 63.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 36 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 25 (a)
ManyToMany
-- 33
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 44 (a)
ManyToMany
-- 33
  • 29 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii APOL4 33
  • 11 (a)
OneToMany
Species where no ortholog for APOL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL6 Gene

ENSEMBL:
Gene Tree for APOL6 (if available)
TreeFam:
Gene Tree for APOL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for APOL6: view image

Paralogs for APOL6 Gene

Paralogs for APOL6 Gene

(5) SIMAP similar genes for APOL6 Gene using alignment to 1 proteins:

  • APOL6_HUMAN
genes like me logo Genes that share paralogs with APOL6: view

Variants for APOL6 Gene

Sequence variations from dbSNP and Humsavar for APOL6 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000219606 -- 35,665,950(+) A/G 3_prime_UTR_variant
rs1000315530 -- 35,650,137(+) G/A intron_variant
rs1000515630 -- 35,661,878(+) G/T 3_prime_UTR_variant
rs1000515655 -- 35,648,099(+) C/G/T upstream_transcript_variant
rs1000855556 -- 35,649,220(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for APOL6 Gene

Variant ID Type Subtype PubMed ID
nsv511076 OTHER complex 20534489

Variation tolerance for APOL6 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOL6 Gene

Human Gene Mutation Database (HGMD)
APOL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOL6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL6 Gene

Disorders for APOL6 Gene

Additional Disease Information for APOL6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for APOL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOL6 Gene

Publications for APOL6 Gene

  1. Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. (PMID: 15671246) Liu Z … Hu CA (Molecular cancer research : MCR 2005) 2 3 23 56
  2. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page NM … Lowry PJ (Genomics 2001) 2 3 4 56
  3. RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function. (PMID: 18571626) Liu YL … Hwu HG (Biological psychiatry 2008) 3 43 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 56

Products for APOL6 Gene

Sources for APOL6 Gene