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Aliases for APOL5 Gene

Aliases for APOL5 Gene

  • Apolipoprotein L5 2 3 3 5
  • Apolipoprotein L-V 3 4
  • Apolipoprotein L, 5 3
  • APOL-V 3
  • ApoL-V 4
  • APOLV 3

External Ids for APOL5 Gene

Previous GeneCards Identifiers for APOL5 Gene

  • GC22P032757
  • GC22P034385
  • GC22P034438
  • GC22P036113
  • GC22P019076

Summaries for APOL5 Gene

Entrez Gene Summary for APOL5 Gene

  • This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL5 Gene

APOL5 (Apolipoprotein L5) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Gene Ontology (GO) annotations related to this gene include lipid binding and high-density lipoprotein particle binding. An important paralog of this gene is APOL6.

UniProtKB/Swiss-Prot for APOL5 Gene

  • May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Additional gene information for APOL5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL5 Gene

Genomics for APOL5 Gene

GeneHancer (GH) Regulatory Elements for APOL5 Gene

Promoters and enhancers for APOL5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J035708 Promoter 0.6 EPDnew 650.7 +0.4 432 0.1 PKNOX1 APOL5 GC22P035694 GC22M035729
GH22J035646 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 4.8 -60.1 -60091 4.1 PKNOX1 FOXA2 ARID4B ZNF48 ETS1 YY1 ZNF121 FOS ATF7 RXRA APOL6 APOL5 MB
GH22J035659 Enhancer 1 Ensembl ENCODE dbSUPER 4.5 -46.9 -46855 4.9 FOXA2 SOX6 HLF ZNF398 FOXA1 YY1 PRDM6 FOXP2 FOS RUNX3 MB APOL5 GC22P035676 APOL6
GH22J035733 Enhancer 0.4 ENCODE 8.4 +25.8 25761 1 HNF4A NR2F2 APOL6 MB APOL5 GC22M035729
GH22J035705 Enhancer 0.5 ENCODE 0.7 -3.0 -2996 0.8 JUND JUN CEBPB FOS EP300 MRPS16P3 APOL5 GC22P035694
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around APOL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the APOL5 gene promoter:
  • HEN1
  • FOXD1
  • c-Myb

Genomic Locations for APOL5 Gene

Genomic Locations for APOL5 Gene
21,902 bases
Plus strand
11,612 bases
Plus strand

Genomic View for APOL5 Gene

Genes around APOL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL5 Gene

Proteins for APOL5 Gene

  • Protein details for APOL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apolipoprotein L5
    Protein Accession:
    Secondary Accessions:
    • Q5TFL9
    • Q9UGW5

    Protein attributes for APOL5 Gene

    433 amino acids
    Molecular mass:
    47044 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOL5 Gene

Post-translational modifications for APOL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOL5 Gene

Domains & Families for APOL5 Gene

Gene Families for APOL5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for APOL5 Gene


Suggested Antigen Peptide Sequences for APOL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the apolipoprotein L family.
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL5: view

Function for APOL5 Gene

Molecular function for APOL5 Gene

UniProtKB/Swiss-Prot Function:
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Phenotypes From GWAS Catalog for APOL5 Gene

Gene Ontology (GO) - Molecular Function for APOL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008035 high-density lipoprotein particle binding NAS 11374903
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with APOL5: view
genes like me logo Genes that share phenotypes with APOL5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOL5 Gene

Localization for APOL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOL5 gene
Compartment Confidence
extracellular 2
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for APOL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with APOL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for APOL5 Gene

Pathways & Interactions for APOL5 Gene

genes like me logo Genes that share pathways with APOL5: view

Pathways by source for APOL5 Gene

Interacting Proteins for APOL5 Gene

Gene Ontology (GO) - Biological Process for APOL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 11374903
GO:0006869 lipid transport IEA --
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL5: view

No data available for SIGNOR curated interactions for APOL5 Gene

Drugs & Compounds for APOL5 Gene

No Compound Related Data Available

Transcripts for APOL5 Gene

mRNA/cDNA for APOL5 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOL5 Gene

Apolipoprotein L, 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOL5 Gene

No ASD Table

Relevant External Links for APOL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOL5 Gene

mRNA differential expression in normal tissues according to GTEx for APOL5 Gene

This gene is overexpressed in Testis (x11.0), Liver (x8.6), and Muscle - Skeletal (x7.6).

Protein differential expression in normal tissues from HIPED for APOL5 Gene

This gene is overexpressed in Urine (44.2) and Adipocyte (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOL5 Gene

Protein tissue co-expression partners for APOL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of APOL5 Gene:


SOURCE GeneReport for Unigene cluster for APOL5 Gene:


mRNA Expression by UniProt/SwissProt for APOL5 Gene:

Tissue specificity: Low level of expression; detected in uterus, testis, skeletal muscle and stomach.
genes like me logo Genes that share expression patterns with APOL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOL5 Gene

Orthologs for APOL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APOL5 34
  • 93 (a)
(Canis familiaris)
Mammalia APOL5 34 33
  • 72.54 (n)
(Bos Taurus)
Mammalia -- 34
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
(Mus musculus)
Mammalia Apol7a 34
  • 28 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 23 (a)
-- 34
  • 23 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
-- 34
  • 30 (a)
(Danio rerio)
Actinopterygii APOL4 34
  • 13 (a)
Species where no ortholog for APOL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL5 Gene

Gene Tree for APOL5 (if available)
Gene Tree for APOL5 (if available)
Evolutionary constrained regions (ECRs) for APOL5: view image

Paralogs for APOL5 Gene

Paralogs for APOL5 Gene

(2) SIMAP similar genes for APOL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APOL5: view

Variants for APOL5 Gene

Sequence variations from dbSNP and Humsavar for APOL5 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000023230 -- 35,727,774(+) A/G intron_variant
rs1000085795 -- 35,721,453(+) G/C intron_variant
rs1000138979 -- 35,707,758(+) A/G upstream_transcript_variant
rs1000235641 -- 35,712,065(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000301863 -- 35,716,966(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for APOL5 Gene

Variant ID Type Subtype PubMed ID
nsv511076 OTHER complex 20534489
nsv3612 CNV insertion 18451855

Variation tolerance for APOL5 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.01; 98.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOL5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL5 Gene

Disorders for APOL5 Gene

Additional Disease Information for APOL5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for APOL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOL5 Gene

Publications for APOL5 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page NM … Lowry PJ (Genomics 2001) 2 3 4 58
  2. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
  3. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PMID: 20691427) Jagannathan K … Pearlson GD (Biological psychiatry 2010) 3 44 58
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  5. EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. (PMID: 24348519) Namjou B … Harley JB (Frontiers in genetics 2013) 3 58

Products for APOL5 Gene

Sources for APOL5 Gene

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