Free for academic non-profit institutions. Other users need a Commercial license

Aliases for APOL4 Gene

Aliases for APOL4 Gene

  • Apolipoprotein L4 2 3 3 5
  • Apolipoprotein L-IV 3 4
  • Apolipoprotein L, 4 3
  • APOL-IV 3
  • ApoL-IV 4
  • APOLIV 3

External Ids for APOL4 Gene

Previous GeneCards Identifiers for APOL4 Gene

  • GC22M033228
  • GC22M034856
  • GC22M034909
  • GC22M036585
  • GC22M019554

Summaries for APOL4 Gene

Entrez Gene Summary for APOL4 Gene

  • The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL4 Gene

APOL4 (Apolipoprotein L4) is a Protein Coding gene. Diseases associated with APOL4 include Schizophrenia. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is APOL3.

UniProtKB/Swiss-Prot for APOL4 Gene

  • May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).

Additional gene information for APOL4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL4 Gene

Genomics for APOL4 Gene

GeneHancer (GH) Regulatory Elements for APOL4 Gene

Promoters and enhancers for APOL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J036201 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 689.4 +1.7 1667 3.9 HDGF ATF1 POLR2B ATF7 REST ZNF592 SMARCA4 ZNF184 HMBOX1 KDM1A APOL4 MTND1P10
GH22J036206 Enhancer 0.2 FANTOM5 677.3 -1.7 -1652 0.2 APOL4 APOL3 APOL2 APOL1
GH22J036196 Enhancer 0.9 Ensembl ENCODE 33.7 +7.1 7128 3.4 CTCF TFAP4 SIN3A BMI1 ZNF335 POLR2A VEZF1 ZNF548 RFX1 STAT1 APOL4 HMGXB4 RPS15AP38 MCM5 MTND1P10
GH22J037182 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -982.0 -982022 8.6 PKNOX1 CLOCK NEUROD1 SIN3A GLIS2 ZNF143 FOS SP3 RXRA NFYC C1QTNF6 EIF3D ENSG00000235237 TMPRSS6 ENSG00000231467 CYTH4 APOL4 CARD10 ENSG00000226233 ENSG00000229971
GH22J036236 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 7.1 -33.8 -33770 3.7 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 APOL2 APOL4 ENSG00000273176
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around APOL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the APOL4 gene promoter:
  • ISGF-3
  • IRF-1
  • IRF-2

Genomic Locations for APOL4 Gene

Genomic Locations for APOL4 Gene
15,717 bases
Minus strand
15,715 bases
Minus strand

Genomic View for APOL4 Gene

Genes around APOL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL4 Gene

Proteins for APOL4 Gene

  • Protein details for APOL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apolipoprotein L4
    Protein Accession:
    Secondary Accessions:
    • Q9BQ37
    • Q9BXQ8

    Protein attributes for APOL4 Gene

    351 amino acids
    Molecular mass:
    39164 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for APOL4 Gene


neXtProt entry for APOL4 Gene

Post-translational modifications for APOL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for APOL4 Gene

Domains & Families for APOL4 Gene

Gene Families for APOL4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for APOL4 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the apolipoprotein L family.
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL4: view

Function for APOL4 Gene

Molecular function for APOL4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).

Phenotypes From GWAS Catalog for APOL4 Gene

Gene Ontology (GO) - Molecular Function for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with APOL4: view
genes like me logo Genes that share phenotypes with APOL4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOL4 Gene

Localization for APOL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOL4 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space ISS 22261194
GO:0016020 membrane IBA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with APOL4: view

Pathways & Interactions for APOL4 Gene

genes like me logo Genes that share pathways with APOL4: view

Pathways by source for APOL4 Gene

Interacting Proteins for APOL4 Gene

Gene Ontology (GO) - Biological Process for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 11944986
GO:0006869 lipid transport IEA --
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL4: view

No data available for SIGNOR curated interactions for APOL4 Gene

Drugs & Compounds for APOL4 Gene

No Compound Related Data Available

Transcripts for APOL4 Gene

mRNA/cDNA for APOL4 Gene

Unigene Clusters for APOL4 Gene

Apolipoprotein L, 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOL4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -

Relevant External Links for APOL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOL4 Gene

mRNA differential expression in normal tissues according to GTEx for APOL4 Gene

This gene is overexpressed in Pituitary (x5.1) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for APOL4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOL4 Gene

Protein tissue co-expression partners for APOL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of APOL4 Gene:


SOURCE GeneReport for Unigene cluster for APOL4 Gene:


mRNA Expression by UniProt/SwissProt for APOL4 Gene:

Tissue specificity: Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas.

Evidence on tissue expression from TISSUES for APOL4 Gene

  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with APOL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOL4 Gene

Orthologs for APOL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia APOL3 34
  • 40 (a)
-- 34
  • 38 (a)
-- 34
  • 32 (a)
(Canis familiaris)
Mammalia -- 34
  • 36 (a)
(Mus musculus)
Mammalia Apol9b 34
  • 34 (a)
Apol9a 34
  • 33 (a)
Apol11a 34
  • 32 (a)
Apol10b 34
  • 30 (a)
Apol10a 34
  • 27 (a)
Apol11b 34
  • 26 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 26 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 20 (a)
-- 34
  • 20 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
-- 34
  • 26 (a)
(Danio rerio)
Actinopterygii APOL4 34
  • 11 (a)
Species where no ortholog for APOL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL4 Gene

Gene Tree for APOL4 (if available)
Gene Tree for APOL4 (if available)
Evolutionary constrained regions (ECRs) for APOL4: view image

Paralogs for APOL4 Gene

Paralogs for APOL4 Gene

(3) SIMAP similar genes for APOL4 Gene using alignment to 11 proteins:

  • E9PS31_HUMAN
  • F5H1P9_HUMAN
genes like me logo Genes that share paralogs with APOL4: view

Variants for APOL4 Gene

Sequence variations from dbSNP and Humsavar for APOL4 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs3075364 likely-benign, not provided 36,191,798(-) CTCT/CTCTCT coding_sequence_variant, frameshift
rs1000063742 -- 36,199,218(-) C/T intron_variant
rs1000183277 -- 36,189,832(-) C/T 3_prime_UTR_variant
rs1000213055 -- 36,194,598(-) G/C intron_variant
rs1000642938 -- 36,194,721(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for APOL4 Gene

Variant ID Type Subtype PubMed ID
nsv1129335 OTHER inversion 24896259
esv7844 OTHER inversion 19470904
esv3647680 CNV loss 21293372

Variation tolerance for APOL4 Gene

Gene Damage Index Score: 4.19; 61.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL4 Gene

Disorders for APOL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for APOL4 Gene - From: OMIM, GTR, and GeneCards

Disorder Aliases PubMed IDs
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search APOL4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for APOL4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with APOL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APOL4 Gene

Publications for APOL4 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page NM … Lowry PJ (Genomics 2001) 2 3 4 58
  2. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau PN … Kane JP (Journal of lipid research 2001) 3 4 22 58
  3. Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. (PMID: 18632255) Takahashi S … Tsuang MT (Schizophrenia research 2008) 3 44 58
  4. Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. (PMID: 15949655) McGhee KA … Corvin A (Schizophrenia research 2005) 3 44 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for APOL4 Gene

Sources for APOL4 Gene

Loading form....