Aliases for APOL3 Gene
External Ids for APOL3 Gene
Previous GeneCards Identifiers for APOL3 Gene
This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
GeneCards Summary for APOL3 Gene
APOL3 (Apolipoprotein L3) is a Protein Coding gene. Diseases associated with APOL3 include Queensland Tick Typhus and Embryoma. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and lipid transporter activity. An important paralog of this gene is APOL4.
UniProtKB/Swiss-Prot Summary for APOL3 Gene
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.