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This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alph... See more...
Aliases for APOL3 Gene
Aliases for APOL3 Gene
External Ids for APOL3 Gene
- HGNC: 14868
- Entrez Gene: 80833
- Ensembl: ENSG00000128284
- OMIM: 607253
- UniProtKB: O95236
Previous GeneCards Identifiers for APOL3 Gene
- GC22M033179
- GC22M034808
- GC22M034860
- GC22M036536
- GC22M019504
Summaries for APOL3 Gene
-
This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
GeneCards Summary for APOL3 Gene
APOL3 (Apolipoprotein L3) is a Protein Coding gene. Diseases associated with APOL3 include Queensland Tick Typhus and Embryoma. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and lipid transporter activity. An important paralog of this gene is APOL4.
UniProtKB/Swiss-Prot Summary for APOL3 Gene
-
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Additional gene information for APOL3 Gene
- HGNC(14868)
- Entrez Gene(80833)
- Ensembl(ENSG00000128284)
- OMIM(607253)
- UniProtKB(O95236)
- Open Targets Platform(ENSG00000128284)
- Search for APOL3 at DataMed
- Search for APOL3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APOL3 Gene
Genomics for APOL3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for APOL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around APOL3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for APOL3
- Top Transcription factor binding sites by QIAGEN in the APOL3 gene promoter:
-
- C/EBPalpha
- En-1
- FOXO4
- Msx-1
- RSRFC4
Genomic Locations for APOL3 Gene
Genomic Locations for APOL3 Gene
- chr22:36,140,323-36,166,177
- (GRCh38/hg38)
- Size:
- 25,855 bases
- Orientation:
- Minus strand
- chr22:36,536,371-36,562,225
- (GRCh37/hg19)
- Size:
- 25,855 bases
- Orientation:
- Minus strand
Genomic View for APOL3 Gene
Genes around APOL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.3 by HGNC
- 22q12.3 by Entrez Gene
- 22q12.3 by Ensembl
APOL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOL3 Gene
Proteins for APOL3 Gene
-
Protein details for APOL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95236-APOL3_HUMAN
- Recommended name:
- Apolipoprotein L3
- Protein Accession:
- O95236
- B1AHI4
- B1AHI5
- Q5U5N4
- Q9BQ82
- Q9BQA3
Protein attributes for APOL3 Gene
- Size:
- 402 amino acids
- Molecular mass:
- 44278 Da
- Quaternary structure:
- No Data Available
Protein Expression for APOL3 Gene
Post-translational modifications for APOL3 Gene
Other Protein References for APOL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ APOL3 Antibody and Immunotag™ ApoL3 Polyclonal Antibody
- Creative Diagnostics Anti-APOL3 (aa 135-184) polyclonal antibody
- Creative Biolabs Recombinant Mouse Anti-Human APOL3 Antibody
- Novus Biologicals Antibodies for APOL3
-
Abcam antibodies for APOL3
- Invitrogen Antibodies for APOL3 (AFLGC-APOL3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for APOL3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for APOL3
- Origene Custom Protein Services for APOL3
- antibodies-online: Show 4 available APOL3 Proteins ranked by validation data
- Compare Top APOL3 Proteins
-
Quality Products:
-
Abcam proteins for APOL3
Assay Products
- antibodies-online: Show 1 available APOL3 Elisa Kits ranked by validation data
- Compare Top APOL3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for APOL3 Gene
Domains & Families for APOL3 Gene
Gene Families for APOL3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for APOL3 Gene
- GenScript: Design optimal peptide antigens:
-
- TNF-inducible protein CG12-1 (APOL3_HUMAN)
- Apolipoprotein L, 3 (B1AHI6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95236- Family:
-
- Belongs to the apolipoprotein L family.
Function for APOL3 Gene
Molecular function for APOL3 Gene
- UniProtKB/Swiss-Prot Function:
- May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
- UniProtKB/Swiss-Prot Induction:
- In vitro, is responsive to TNF.
Phenotypes From GWAS Catalog for APOL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005319 | lipid transporter activity | TAS | 10233894 |
| GO:0008289 | lipid binding | IBA | 21873635 |
Phenotypes for APOL3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for APOL3 - Select products 50% OFF >
- * APOL3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for APOL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOL3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOL3
- Browse OriGene Inhibitory RNA Products For APOL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOL3
Clone Products
- Applied Biological Materials (abm): Clones for APOL3 - Select products 50% OFF >
- * APOL3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- RC208325
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- RC212625L4
- RC215191
- RC215191L1
- RC215191L2
- RC215191L3
- RC215191L4
- RC218012
- RC218012L3
- RC218012L4
- RC220066
- RC220066L3
- RC220066L4
- RG208325
- RG208643
- RG212625
- RG215191
- RG218012
- RG220066
- RR210234
- RR210234L3
- RR210234L4
- RR216396
- RC208325L3V
- RC208325L4V
- RC208643L3V
- RC208643L4V
- RC212625L1V
- RC212625L2V
- RC212625L3V
- RC212625L4V
- RC215191L1V
- RC215191L2V
- RC215191L3V
- RC215191L4V
- RC218012L3V
- RC218012L4V
- RC220066L3V
- RC220066L4V
- RR210234L3V
- RR210234L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for APOL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOL3
Cell Line Products
-
Horizon Cell Lines for APOL3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOL3 Gene
Localization for APOL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOL3 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016020 | membrane | HDA | 19946888 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for APOL3 Gene
Pathways & Interactions for APOL3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF) |
Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
-
|
|
Pathways by source for APOL3 Gene
1 GeneGo (Thomson Reuters) pathway for APOL3 Gene
- Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
Interacting Proteins for APOL3 Gene
Selected Interacting proteins:
O95236-APOL3_HUMAN
ENSP00000344577
for APOL3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for APOL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006869 | lipid transport | IEA | -- |
| GO:0006954 | inflammatory response | TAS | 10233894 |
| GO:0042157 | lipoprotein metabolic process | IEA | -- |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | HMP | 12761501 |
No data available for SIGNOR curated interactions for APOL3 Gene
Transcripts for APOL3 Gene
mRNA/cDNA for APOL3 Gene
- 6 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000349314 2117 nts (view in UCSC)
- ENST00000432700 2443 nts (view in UCSC)
- ENST00000422426 2327 nts (view in UCSC)
- ENST00000397289 2214 nts (view in UCSC)
- ENST00000361710 3563 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for APOL3 - Select products 50% OFF >
- * APOL3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for APOL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOL3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOL3
- Browse OriGene Inhibitory RNA Products For APOL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOL3
Clone Products
- Applied Biological Materials (abm): Clones for APOL3 - Select products 50% OFF >
- * APOL3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- RC208325
- RC208325L3
- RC208325L4
- RC208643
- RC208643L3
- RC208643L4
- RC212625
- RC212625L1
- RC212625L2
- RC212625L3
- RC212625L4
- RC215191
- RC215191L1
- RC215191L2
- RC215191L3
- RC215191L4
- RC218012
- RC218012L3
- RC218012L4
- RC220066
- RC220066L3
- RC220066L4
- RG208325
- RG208643
- RG212625
- RG215191
- RG218012
- RG220066
- RR210234
- RR210234L3
- RR210234L4
- RR216396
- RC208325L3V
- RC208325L4V
- RC208643L3V
- RC208643L4V
- RC212625L1V
- RC212625L2V
- RC212625L3V
- RC212625L4V
- RC215191L1V
- RC215191L2V
- RC215191L3V
- RC215191L4V
- RC218012L3V
- RC218012L4V
- RC220066L3V
- RC220066L4V
- RR210234L3V
- RR210234L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for APOL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOL3
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | · | 12f | · | 12g |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP15: |
Relevant External Links for APOL3 Gene
- GeneLoc Exon Structure for
- APOL3
Expression for APOL3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Endothelium (Cardiovascular System)
This gene is overexpressed in Urine (15.4), Peripheral blood mononuclear cells (13.5), and Plasma (10.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APOL3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APOL3
SOURCE GeneReport for Unigene cluster for APOL3 Gene:
Hs.474737mRNA Expression by UniProt/SwissProt for APOL3 Gene:
O95236-APOL3_HUMAN
Tissue specificity:
Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis.
Evidence on tissue expression from TISSUES for APOL3 Gene
- Liver(4.6)
- Heart(4.5)
- Blood(4.4)
- Spleen(4.2)
- Pancreas(4.1)
- Lung(3.7)
- Nervous system(3.4)
- Intestine(3.1)
- Muscle(2.3)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for APOL3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOL3 Gene
Orthologs for APOL3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | APOL3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LOC100847379 30 |
|
||
| APOL3 31 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | LOC100910885 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Apol8 31 |
|
ManyToMany | |
| Apol9a 31 |
|
ManyToMany | |||
| Apol7c 31 |
|
ManyToMany | |||
| Apol9b 31 |
|
ManyToMany | |||
| Apol7b 31 |
|
ManyToMany | |||
| Apol7e 31 |
|
ManyToMany | |||
| Apol11a 31 |
|
ManyToMany | |||
| Apol10b 31 |
|
ManyToMany | |||
| Apol10a 31 |
|
ManyToMany | |||
| Apol11b 31 |
|
ManyToMany | |||
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | APOL4 31 |
|
OneToMany |
- Species where no ortholog for APOL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for APOL3 Gene
- ENSEMBL:
- Gene Tree for APOL3 (if available)
- TreeFam:
- Gene Tree for APOL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for APOL3: view image
Paralogs for APOL3 Gene
(5) SIMAP similar genes for APOL3 Gene using alignment to 9 proteins:
- APOL3_HUMAN
- F2Z2M3_HUMAN
- H0YCT0_HUMAN
- H0YD32_HUMAN
- H0YDH5_HUMAN
- H0YDW3_HUMAN
- H0YEJ6_HUMAN
- H0YEQ0_HUMAN
- H7BYQ5_HUMAN
Variants for APOL3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APOL3 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 714120 | Likely Benign: not provided | 36,141,764(-) | C/T | SYNONYMOUS_VARIANT | |
| 747554 | Likely Benign: not provided | 36,160,788(-) | C/A | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 764006 | Benign: not provided | 36,160,826(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 764007 | Likely Benign: not provided | 36,160,853(-) | A/C | MISSENSE_VARIANT,INTRON_VARIANT | |
| 771540 | Benign: not provided | 36,145,519(-) | T/C | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4563n100 | CNV | loss | 25217958 |
| dgv8093n54 | CNV | loss | 21841781 |
| esv2751964 | CNV | loss | 17911159 |
| esv2762122 | CNV | loss | 21179565 |
| esv3307709 | CNV | mobile element insertion | 20981092 |
| esv3307902 | CNV | mobile element insertion | 20981092 |
| esv3356489 | CNV | insertion | 20981092 |
| esv3431226 | CNV | insertion | 20981092 |
| esv3575477 | CNV | gain | 25503493 |
| esv3647677 | CNV | loss | 21293372 |
| nsv521866 | CNV | loss | 19592680 |
| nsv526454 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.43;
63.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for APOL3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL3 Gene
Disorders for APOL3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| queensland tick typhus |
|
|
| embryoma |
|
|
Search APOL3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for APOL3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for APOL3 Gene
Publications for APOL3 Gene
- The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page NM … Lowry PJ (Genomics 2001) 2 3 4
- Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau PN … Kane JP (Journal of lipid research 2001) 3 4 23
- Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets AJ … Pannekoek H (Blood 1999) 3 4 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 41
ExternalLinks
Products for APOL3 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for APOL3
- Origene Custom Protein Services for APOL3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOL3
- Browse OriGene Inhibitory RNA Products For APOL3
- OriGene qPCR primer pairs for APOL3
- OriGene CRISPR knockouts for APOL3
- RC208325
- RC208325L3
- RC208325L4
- RC208643
- RC208643L3
- RC208643L4
- RC212625
- RC212625L1
- RC212625L2
- RC212625L3
- RC212625L4
- RC215191
- RC215191L1
- RC215191L2
- RC215191L3
- RC215191L4
- RC218012
- RC218012L3
- RC218012L4
- RC220066
- RC220066L3
- RC220066L4
- RG208325
- RG208643
- RG212625
- RG215191
- RG218012
- RG220066
- RR210234
- RR210234L3
- RR210234L4
- RR216396
- RC208325L3V
- RC208325L4V
- RC208643L3V
- RC208643L4V
- RC212625L1V
- RC212625L2V
- RC212625L3V
- RC212625L4V
- RC215191L1V
- RC215191L2V
- RC215191L3V
- RC215191L4V
- RC218012L3V
- RC218012L4V
- RC220066L3V
- RC220066L4V
- RR210234L3V
- RR210234L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For APOL3
- Sino Biological Human cDNA Clone for APOL3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for APOL3
- Novus Biologicals proteins and lysates for APOL3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for APOL3
- Abcam proteins for APOL3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for APOL3 (AFLGC-APOL3)
- VectorBuilder Custom and pre-made DNA vectors for APOL3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for APOL3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for APOL3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for APOL3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for APOL3
- antibodies-online: Show 24 available APOL3 Antibodies ranked by validation data
- Compare Top APOL3 Antibodies
- antibodies-online: Show 1 available APOL3 Elisa Kits ranked by validation data
- Compare Top APOL3 Elisa Kits
- Quality Products:
- antibodies-online: Show 4 available APOL3 Proteins ranked by validation data
- Compare Top APOL3 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for APOL3
- Search Santa Cruz Biotechnology (SCBT) for APOL3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for APOL3
- Horizon Cell Lines for APOL3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOL3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for APOL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOL3
Sources for APOL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB