This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for APOL2 Gene

Aliases for APOL2 Gene

  • Apolipoprotein L2 2 3 4 5
  • Apolipoprotein L-II 2 3 4
  • APOL-II 2 3
  • Apolipoprotein L, 2 3
  • ApoL-II 4
  • APOL3 3
  • APOL2 5

External Ids for APOL2 Gene

Previous GeneCards Identifiers for APOL2 Gene

  • GC22M033265
  • GC22M034894
  • GC22M034946
  • GC22M036622
  • GC22M019590

Summaries for APOL2 Gene

Entrez Gene Summary for APOL2 Gene

  • This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL2 Gene

APOL2 (Apolipoprotein L2) is a Protein Coding gene. Diseases associated with APOL2 include Schizophrenia and Phencyclidine Abuse. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and high-density lipoprotein particle binding. An important paralog of this gene is APOL1.

UniProtKB/Swiss-Prot Summary for APOL2 Gene

  • May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Gene Wiki entry for APOL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APOL2 Gene

Genomics for APOL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for APOL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APOL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for APOL2

Top Transcription factor binding sites by QIAGEN in the APOL2 gene promoter:
  • Bach1
  • GR
  • GR-alpha
  • GR-beta
  • RREB-1

Genomic Locations for APOL2 Gene

Genomic Locations for APOL2 Gene
chr22:36,226,209-36,239,954
(GRCh38/hg38)
Size:
13,746 bases
Orientation:
Minus strand
chr22:36,622,255-36,636,000
(GRCh37/hg19)
Size:
13,746 bases
Orientation:
Minus strand

Genomic View for APOL2 Gene

Genes around APOL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL2 Gene

Proteins for APOL2 Gene

  • Protein details for APOL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQE5-APOL2_HUMAN
    Recommended name:
    Apolipoprotein L2
    Protein Accession:
    Q9BQE5
    Secondary Accessions:
    • B0QYK7
    • O95915
    • Q59GW9
    • Q5TH96
    • Q969T6
    • Q9BT28
    • Q9UGT1
    • Q9UH10

    Protein attributes for APOL2 Gene

    Size:
    337 amino acids
    Molecular mass:
    37092 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92227.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for APOL2 Gene

Post-translational modifications for APOL2 Gene

  • Ubiquitination at Lys83, Lys193, Lys196, Lys320, and Lys326
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for APOL2 Gene

Domains & Families for APOL2 Gene

Gene Families for APOL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for APOL2 Gene

InterPro:
Blocks:
  • Apolipoprotein L
ProtoNet:

Suggested Antigen Peptide Sequences for APOL2 Gene

GenScript: Design optimal peptide antigens:
  • Apolipoprotein L-II (APOL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BQE5

UniProtKB/Swiss-Prot:

APOL2_HUMAN :
  • Belongs to the apolipoprotein L family.
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL2: view

Function for APOL2 Gene

Molecular function for APOL2 Gene

UniProtKB/Swiss-Prot Function:
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
GENATLAS Biochemistry:
apolipoprotein L,2

Phenotypes From GWAS Catalog for APOL2 Gene

Gene Ontology (GO) - Molecular Function for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding NAS 11374903
GO:0008035 high-density lipoprotein particle binding NAS 11374903
GO:0008289 lipid binding IEA,NAS 11374903
genes like me logo Genes that share ontologies with APOL2: view
genes like me logo Genes that share phenotypes with APOL2: view

Human Phenotype Ontology for APOL2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOL2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for APOL2 Gene

Localization for APOL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOL2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 3
nucleus 3
cytosol 3
cytoskeleton 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane NAS 11374903
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APOL2: view

Pathways & Interactions for APOL2 Gene

PathCards logo

SuperPathways for APOL2 Gene

SuperPathway Contained pathways
1 Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
-
genes like me logo Genes that share pathways with APOL2: view

Pathways by source for APOL2 Gene

1 GeneGo (Thomson Reuters) pathway for APOL2 Gene
  • Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)

Gene Ontology (GO) - Biological Process for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 11374903
GO:0006869 lipid transport IEA,NAS 11374903
GO:0006953 acute-phase response NAS 11374903
GO:0007275 multicellular organism development NAS 11374903
GO:0008203 cholesterol metabolic process NAS 11374903
genes like me logo Genes that share ontologies with APOL2: view

No data available for SIGNOR curated interactions for APOL2 Gene

Drugs & Compounds for APOL2 Gene

No Compound Related Data Available

Transcripts for APOL2 Gene

mRNA/cDNA for APOL2 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOL2

Alternative Splicing Database (ASD) splice patterns (SP) for APOL2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - - -
SP8: - - -
SP9: - -
SP10: -

Relevant External Links for APOL2 Gene

GeneLoc Exon Structure for
APOL2

Expression for APOL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for APOL2 Gene

Protein differential expression in normal tissues from HIPED for APOL2 Gene

This gene is overexpressed in Nasal epithelium (26.1) and Bone (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOL2 Gene



Protein tissue co-expression partners for APOL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APOL2

SOURCE GeneReport for Unigene cluster for APOL2 Gene:

Hs.474740

mRNA Expression by UniProt/SwissProt for APOL2 Gene:

Q9BQE5-APOL2_HUMAN
Tissue specificity: Widely expressed; the highest levels are found in lung, thymus, pancreas, placenta, adult brain and prostate; also detected in spleen, liver, kidney, colon, small intestine, uterus, spinal cord, adrenal gland, salivary gland, trachea, mammary gland, skeletal muscle, testis and fetal brain and liver.

Evidence on tissue expression from TISSUES for APOL2 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Heart(4.5)
  • Pancreas(4.3)
  • Kidney(2.4)
  • Blood(2.4)
  • Spleen(2.2)
  • Lung(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with APOL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOL2 Gene

Orthologs for APOL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia APOL2 30 31
  • 98.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia APOL3 30 31
  • 66.56 (n)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Apol8 30 17
  • 64.73 (n)
Apol9b 31
  • 41 (a)
ManyToMany
Apol9a 31
  • 38 (a)
ManyToMany
Apol10b 31
  • 34 (a)
ManyToMany
Apol11a 31
  • 34 (a)
ManyToMany
Apol10a 31
  • 30 (a)
ManyToMany
Apol11b 31
  • 30 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia LOC100911804 30
  • 64.09 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 38 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 28 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 25 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 44 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii APOL4 31
  • 13 (a)
OneToMany
Species where no ortholog for APOL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for APOL2 Gene

ENSEMBL:
Gene Tree for APOL2 (if available)
TreeFam:
Gene Tree for APOL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for APOL2: view image

Paralogs for APOL2 Gene

Paralogs for APOL2 Gene

(5) SIMAP similar genes for APOL2 Gene using alignment to 4 proteins:

  • APOL2_HUMAN
  • B0QYK8_HUMAN
  • E9PM95_HUMAN
  • J3KQL8_HUMAN

Pseudogenes.org Pseudogenes for APOL2 Gene

genes like me logo Genes that share paralogs with APOL2: view

Variants for APOL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APOL2 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
781770 Benign: not provided 36,228,185(-) C/T MISSENSE_VARIANT
rs132760 - p.Ile245Val
rs7285167 - p.Arg182Cys

Additional dbSNP identifiers (rs#s) for APOL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for APOL2 Gene

Variant ID Type Subtype PubMed ID
dgv4564n100 CNV gain 25217958
esv1003985 CNV deletion 20482838
esv2760715 CNV gain 21179565
esv3568384 CNV loss 25503493
esv3647680 CNV loss 21293372
esv3647682 CNV gain 21293372
esv3647683 CNV loss 21293372
esv7844 OTHER inversion 19470904
nsv1129335 OTHER inversion 24896259
nsv522931 CNV gain 19592680
nsv834185 CNV loss 17160897

Variation tolerance for APOL2 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.42; 88.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL2 Gene

Disorders for APOL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for APOL2 Gene - From: OMIM, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
phencyclidine abuse
  • pcp abuse
myasthenic syndrome, congenital, 14
  • cms14
- elite association - COSMIC cancer census association via MalaCards
Search APOL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for APOL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with APOL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APOL2 Gene

Publications for APOL2 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page NM … Lowry PJ (Genomics 2001) 2 3 4
  2. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau PN … Kane JP (Journal of lipid research 2001) 3 4 23
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4
  4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 41
  5. Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. (PMID: 18632255) Takahashi S … Tsuang MT (Schizophrenia research 2008) 3 41

Products for APOL2 Gene

  • Signalway ELISA kits for APOL2

Sources for APOL2 Gene