Aliases for APOL1 Gene
External Ids for APOL1 Gene
Previous HGNC Symbols for APOL1 Gene
Previous GeneCards Identifiers for APOL1 Gene
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
GeneCards Summary for APOL1 Gene
APOL1 (Apolipoprotein L1) is a Protein Coding gene. Diseases associated with APOL1 include Focal Segmental Glomerulosclerosis 4 and Glomerulonephritis. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Gene Ontology (GO) annotations related to this gene include lipid binding and chloride channel activity. An important paralog of this gene is APOL2.
UniProtKB/Swiss-Prot Summary for APOL1 Gene
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.