Aliases for APOH Gene
External Ids for APOH Gene
Previous HGNC Symbols for APOH Gene
Previous GeneCards Identifiers for APOH Gene
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOH Gene
APOH (Apolipoprotein H) is a Protein Coding gene. Diseases associated with APOH include Antiphospholipid Syndrome and Syphilis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Statin Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and heparin binding. An important paralog of this gene is CSMD3.
UniProtKB/Swiss-Prot Summary for APOH Gene
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.