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Aliases for APOF Gene

Aliases for APOF Gene

  • Apolipoprotein F 2 3 3 5
  • Lipid Transfer Inhibitor Protein 3 4
  • Apo-F 3 4
  • LTIP 3 4

External Ids for APOF Gene

Previous GeneCards Identifiers for APOF Gene

  • GC12P056570
  • GC12P056542
  • GC12M056471
  • GC12M055040
  • GC12M055010
  • GC12M056754
  • GC12M053793

Summaries for APOF Gene

Entrez Gene Summary for APOF Gene

  • The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOF Gene

APOF (Apolipoprotein F) is a Protein Coding gene. Among its related pathways are Lipoprotein metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and lipid transporter activity.

UniProtKB/Swiss-Prot for APOF Gene

  • Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Gene Wiki entry for APOF Gene

Additional gene information for APOF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOF Gene

Genomics for APOF Gene

GeneHancer (GH) Regulatory Elements for APOF Gene

Promoters and enhancers for APOF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J056362 Promoter 1.2 EPDnew 650.7 +0.0 4 0.1 ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA YY1 ZNF614 EGR1 CREM APOF STAT2 GC12P056293
GH12J056361 Enhancer 0.5 ENCODE 650.7 +1.1 1111 0.2 TFAP4 ZNF777 SAP130 POLR2A RAD21 STAT2 APOF GC12P056293
GH12J056768 Enhancer 0.8 FANTOM5 39.6 -405.8 -405845 0.2 FOXA2 TAF1 MAX CEBPG RAD21 YY1 IRF9 CTBP1 GATA3 GATAD2A APOF HSD17B6 RDH16 SPRYD4 GLS2 GPR182 NACA MYO1A PAN2 PIR51277
GH12J056447 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 -86.2 -86244 2.3 HDGF CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 TIMELESS BAZ2A DNAJC14 NEMP1 STAT2 RN7SL809P PRIM1 ZC3H10 PYM1 CDK2
GH12J056564 Enhancer 1.1 Ensembl ENCODE 9.9 -205.4 -205386 7.7 ARID4B ZNF48 ATF7 RUNX3 REST PPARG KAT8 GLIS1 ETV4 CTCF RBMS2 GLS2 BAZ2A SPRYD4 APOF SNORD59A SNORD59B ATP5F1B NACA GC12P056589
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APOF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the APOF gene promoter:
  • p53
  • Sp1
  • Pax-2b
  • Pax-2a
  • Pax-2
  • RP58
  • USF1
  • USF-1
  • SRF (504 AA)

Genomic Locations for APOF Gene

Genomic Locations for APOF Gene
chr12:56,360,569-56,362,823
(GRCh38/hg38)
Size:
2,255 bases
Orientation:
Minus strand
chr12:56,754,353-56,756,607
(GRCh37/hg19)
Size:
2,255 bases
Orientation:
Minus strand

Genomic View for APOF Gene

Genes around APOF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOF Gene

Proteins for APOF Gene

  • Protein details for APOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13790-APOF_HUMAN
    Recommended name:
    Apolipoprotein F
    Protein Accession:
    Q13790
    Secondary Accessions:
    • Q8TC13

    Protein attributes for APOF Gene

    Size:
    326 amino acids
    Molecular mass:
    35399 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOF Gene

Post-translational modifications for APOF Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at posLast=274274 and posLast=118118
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • APOF_HUMAN (702)

Other Protein References for APOF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOF Gene

Domains & Families for APOF Gene

Gene Families for APOF Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for APOF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13790

UniProtKB/Swiss-Prot:

APOF_HUMAN :
  • Belongs to the apolipoprotein F family.
Family:
  • Belongs to the apolipoprotein F family.
genes like me logo Genes that share domains with APOF: view

Function for APOF Gene

Molecular function for APOF Gene

UniProtKB/Swiss-Prot Function:
Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.
GENATLAS Biochemistry:
apoliprotein F,high density,29kDa,only expressed in liver

Phenotypes From GWAS Catalog for APOF Gene

Gene Ontology (GO) - Molecular Function for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 8093033
GO:0005319 lipid transporter activity TAS 6816269
GO:0015485 cholesterol binding TAS 6816269
genes like me logo Genes that share ontologies with APOF: view
genes like me logo Genes that share phenotypes with APOF: view

Animal Models for APOF Gene

MGI Knock Outs for APOF:
  • Apof Apof<tm1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for APOF

miRNA for APOF Gene

miRTarBase miRNAs that target APOF

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APOF Gene

Localization for APOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOF gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 28935895
GO:0034362 low-density lipoprotein particle IEA --
GO:0034364 high-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with APOF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for APOF Gene

Pathways & Interactions for APOF Gene

genes like me logo Genes that share pathways with APOF: view

Gene Ontology (GO) - Biological Process for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 8093033
GO:0006869 lipid transport IEA,TAS --
GO:0008202 steroid metabolic process IEA --
GO:0008203 cholesterol metabolic process IEA,TAS --
genes like me logo Genes that share ontologies with APOF: view

No data available for SIGNOR curated interactions for APOF Gene

Drugs & Compounds for APOF Gene

(2) Drugs for APOF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for APOF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APOF: view

Transcripts for APOF Gene

mRNA/cDNA for APOF Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOF Gene

Apolipoprotein F:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOF Gene

No ASD Table

Relevant External Links for APOF Gene

GeneLoc Exon Structure for
APOF
ECgene alternative splicing isoforms for
APOF

Expression for APOF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOF Gene

This gene is overexpressed in Liver (x52.6).

Protein differential expression in normal tissues from HIPED for APOF Gene

This gene is overexpressed in Serum (45.6) and Plasma (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOF Gene



NURSA nuclear receptor signaling pathways regulating expression of APOF Gene:

APOF

SOURCE GeneReport for Unigene cluster for APOF Gene:

Hs.534302

mRNA Expression by UniProt/SwissProt for APOF Gene:

Q13790-APOF_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for APOF Gene

  • Liver(4.6)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with APOF: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOF Gene

Orthologs for APOF Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOF 34 33
  • 99.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia APOF 34 33
  • 78.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia APOF 34 33
  • 77.96 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apof 33
  • 75.19 (n)
mouse
(Mus musculus)
Mammalia Apof 16 34 33
  • 73.27 (n)
lizard
(Anolis carolinensis)
Reptilia APOF 34
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii apof 34
  • 19 (a)
OneToOne
Species where no ortholog for APOF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOF Gene

ENSEMBL:
Gene Tree for APOF (if available)
TreeFam:
Gene Tree for APOF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for APOF: view image

Paralogs for APOF Gene

Pseudogenes.org Pseudogenes for APOF Gene

genes like me logo Genes that share paralogs with APOF: view

No data available for Paralogs for APOF Gene

Variants for APOF Gene

Sequence variations from dbSNP and Humsavar for APOF Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000164732 -- 56,362,395(-) G/A intron_variant
rs1001228611 -- 56,362,101(-) A/G coding_sequence_variant, synonymous_variant
rs1001243556 -- 56,364,673(-) A/T upstream_transcript_variant
rs1001608340 -- 56,361,604(-) T/C coding_sequence_variant, missense_variant
rs1001619806 -- 56,361,975(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for APOF Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for APOF Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOF Gene

Disorders for APOF Gene

Additional Disease Information for APOF

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for APOF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOF Gene

Publications for APOF Gene

  1. Purification and molecular cloning of human apolipoprotein F. (PMID: 8093033) Day JR … Wolfbauer G (Biochemical and biophysical research communications 1994) 2 3 4 22 58
  2. Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F. (PMID: 9880564) Wang X … Morton RE (The Journal of biological chemistry 1999) 3 4 22 58
  3. Absolute quantitation of disease protein biomarkers in a single LC-MS acquisition using apolipoprotein F as an example. (PMID: 28935895) Kumar A … Zitzmann N (Scientific reports 2017) 3 4 58
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58

Products for APOF Gene

Sources for APOF Gene

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