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Aliases for APOC4-APOC2 Gene

Subcategory (RNA class) for APOC4-APOC2 Gene

ncRNA

Quality Score for this RNA gene is

13

Aliases for APOC4-APOC2 Gene

  • APOC4-APOC2 Readthrough (NMD Candidate) 2 3 5
  • Apolipoprotein C-II, Isoform CRA_a 12
  • APOC4-APOC2 Readthrough 2
  • Protein APOC4-APOC2 12
  • APOC2 12

External Ids for APOC4-APOC2 Gene

Previous GeneCards Identifiers for APOC4-APOC2 Gene

  • GC19U901523
  • GC19P045446

Summaries for APOC4-APOC2 Gene

Entrez Gene Summary for APOC4-APOC2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring apolipoprotein C-IV (APOC4) and apolipoprotein C-II (APOC2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011]

GeneCards Summary for APOC4-APOC2 Gene

APOC4-APOC2 (APOC4-APOC2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme activator activity. An important paralog of this gene is APOC4.

Additional gene information for APOC4-APOC2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC4-APOC2 Gene

Genomics for APOC4-APOC2 Gene

GeneHancer (GH) Regulatory Elements for APOC4-APOC2 Gene

Promoters and enhancers for APOC4-APOC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044943 Enhancer 1.1 Ensembl ENCODE 650.7 +1.7 1732 0.6 HDGF PKNOX1 ATF1 ARNT IRF4 YY1 ATF7 RXRA REST ZNF592 APOC4 APOC4-APOC2 APOC2
GH19J044942 Promoter 1 EPDnew 650.7 +0.0 17 0.1 TAF1 MAX STAT5A RBPJ RAD21 RARA YY1 ZFHX2 EGR1 NFATC1 APOC4 APOC4-APOC2 APOC2
GH19J044945 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 0.7 +3.7 3712 1.8 ELF3 FOXA2 ARID4B DMAP1 THRB ZSCAN9 RAD21 RARA YY1 EGR1 APOC2 CLPTM1 APOC4 APOC4-APOC2
GH19J044934 Enhancer 1 ENCODE 0.4 -6.5 -6462 2.9 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF121 NFKBIZ RXRA APOC2 APOC1 APOC4 APOC4-APOC2 GC19P044927
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APOC4-APOC2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for APOC4-APOC2 Gene

Genomic Locations for APOC4-APOC2 Gene
chr19:44,942,238-44,949,565
(GRCh38/hg38)
Size:
7,328 bases
Orientation:
Plus strand
chr19:45,445,495-45,452,822
(GRCh37/hg19)
Size:
7,328 bases
Orientation:
Plus strand

Genomic View for APOC4-APOC2 Gene

Genes around APOC4-APOC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOC4-APOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOC4-APOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC4-APOC2 Gene

Proteins for APOC4-APOC2 Gene

  • Protein details for APOC4-APOC2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R0T9-A0A024R0T9_HUMAN
    Recommended name:
    Apolipoprotein C-II isoform 1
    Protein Accession:
    A0A024R0T9

    Protein attributes for APOC4-APOC2 Gene

    Size:
    101 amino acids
    Molecular mass:
    11284 Da
    Quaternary structure:
    No Data Available
  • Protein details for APOC4-APOC2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    K7ER74-K7ER74_HUMAN
    Recommended name:
    APOC4-APOC2 readthrough (NMD candidate)
    Protein Accession:
    K7ER74

    Protein attributes for APOC4-APOC2 Gene

    Size:
    178 amino acids
    Molecular mass:
    20049 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOC4-APOC2 Gene

Post-translational modifications for APOC4-APOC2 Gene

No Post-translational modifications

Other Protein References for APOC4-APOC2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for APOC4-APOC2 Gene

Domains & Families for APOC4-APOC2 Gene

Gene Families for APOC4-APOC2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for APOC4-APOC2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APOC4-APOC2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for APOC4-APOC2 Gene

Function for APOC4-APOC2 Gene

Phenotypes From GWAS Catalog for APOC4-APOC2 Gene

Gene Ontology (GO) - Molecular Function for APOC4-APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with APOC4-APOC2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOC4-APOC2 Gene

Localization for APOC4-APOC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOC4-APOC2 gene
Compartment Confidence
extracellular 5
endosome 4

Gene Ontology (GO) - Cellular Components for APOC4-APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042627 chylomicron IEA --
genes like me logo Genes that share ontologies with APOC4-APOC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for APOC4-APOC2 Gene

Pathways & Interactions for APOC4-APOC2 Gene

SuperPathways for APOC4-APOC2 Gene

No Data Available

Interacting Proteins for APOC4-APOC2 Gene

Gene Ontology (GO) - Biological Process for APOC4-APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with APOC4-APOC2: view

No data available for Pathways by source and SIGNOR curated interactions for APOC4-APOC2 Gene

Drugs & Compounds for APOC4-APOC2 Gene

No Compound Related Data Available

Transcripts for APOC4-APOC2 Gene

mRNA/cDNA for APOC4-APOC2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(1) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for APOC4-APOC2 Gene

No ASD Table

Relevant External Links for APOC4-APOC2 Gene

GeneLoc Exon Structure for
APOC4-APOC2
ECgene alternative splicing isoforms for
APOC4-APOC2

Expression for APOC4-APOC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOC4-APOC2 Gene

Protein differential expression in normal tissues from HIPED for APOC4-APOC2 Gene

This gene is overexpressed in Serum (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for APOC4-APOC2 Gene



Protein tissue co-expression partners for APOC4-APOC2 Gene

Evidence on tissue expression from TISSUES for APOC4-APOC2 Gene

  • Liver(4.6)
  • Lung(4.2)
  • Muscle(4.2)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with APOC4-APOC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOC4-APOC2 Gene

Orthologs for APOC4-APOC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC4-APOC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 60 (a)
OneToMany
cow
(Bos Taurus)
Mammalia APOC4 34
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Apoc4 34
  • 57 (a)
OneToMany
Species where no ortholog for APOC4-APOC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOC4-APOC2 Gene

ENSEMBL:
Gene Tree for APOC4-APOC2 (if available)
TreeFam:
Gene Tree for APOC4-APOC2 (if available)

Paralogs for APOC4-APOC2 Gene

Paralogs for APOC4-APOC2 Gene

(2) SIMAP similar genes for APOC4-APOC2 Gene using alignment to 1 proteins:

  • K7ER74_HUMAN
genes like me logo Genes that share paralogs with APOC4-APOC2: view

Variants for APOC4-APOC2 Gene

Sequence variations from dbSNP and Humsavar for APOC4-APOC2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1130742 benign, Apolipoprotein C2 deficiency 44,949,555(+) C/T non_coding_transcript_variant
rs120074111 pathogenic, APOLIPOPROTEIN C-II (PADOVA), Apolipoprotein C2 deficiency, APOLIPOPROTEIN C-II (BARI) 44,948,822(+) C/A/G/T non_coding_transcript_variant
rs120074112 pathogenic, APOLIPOPROTEIN C-II (PARIS), Apolipoprotein C2 deficiency 44,948,479(+) A/G non_coding_transcript_variant
rs120074114 pathogenic, Apolipoprotein c-ii variant 44,948,767(+) A/C non_coding_transcript_variant
rs120074115 pathogenic, APOLIPOPROTEIN C-II (WAKAYAMA), Apolipoprotein C2 deficiency 44,948,787(+) T/C non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for APOC4-APOC2 Gene

Variant ID Type Subtype PubMed ID
nsv509747 CNV insertion 20534489

Variation tolerance for APOC4-APOC2 Gene

Gene Damage Index Score: 1.79; 33.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOC4-APOC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOC4-APOC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOC4-APOC2 Gene

Disorders for APOC4-APOC2 Gene

Additional Disease Information for APOC4-APOC2

No disorders were found for APOC4-APOC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOC4-APOC2 Gene

Publications for APOC4-APOC2 Gene

  1. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre RN … Friedlander Y (Journal of lipid research 2015) 3 58
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. (PMID: 8530039) Allan CM … Taylor JM (Genomics 1995) 3 58

Products for APOC4-APOC2 Gene

Sources for APOC4-APOC2 Gene

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