This locus represents naturally occurring read-through transcription between the neighboring apolipoprotein C-IV (APOC4) and apolipoprotein C-II (APOC2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011] See more...

Aliases for APOC4-APOC2 Gene

Subcategory (RNA class) for APOC4-APOC2 Gene

lncRNA

Number of RNA Genes sources:

1 / 17

Aliases for APOC4-APOC2 Gene

  • APOC4-APOC2 Readthrough (NMD Candidate) 2 3 5 13
  • APOC4-APOC2 Readthrough 2
  • Apolipoprotein C-IV 3
  • Apolipoprotein C4 3
  • NONHSAG026012.2 91
  • APOC4-APOC2 5
  • Apo-CIV 3
  • ApoC-IV 3
  • APOC4 3

External Ids for APOC4-APOC2 Gene

Previous GeneCards Identifiers for APOC4-APOC2 Gene

  • GC19U901523
  • GC19P045446

Summaries for APOC4-APOC2 Gene

Entrez Gene Summary for APOC4-APOC2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring apolipoprotein C-IV (APOC4) and apolipoprotein C-II (APOC2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011]

GeneCards Summary for APOC4-APOC2 Gene

APOC4-APOC2 (APOC4-APOC2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme activator activity. An important paralog of this gene is APOC4.

Additional gene information for APOC4-APOC2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APOC4-APOC2 Gene

Genomics for APOC4-APOC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for APOC4-APOC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044943 Promoter/Enhancer 1.2 Ensembl ENCODE 600.7 +1.7 1732 0.6 ZNF512 LEF1 POLR2A JUND MTA2 PKNOX1 MTA1 SP1 ZNF24 DPF2 APOC4 APOC4-APOC2 APOC2
GH19J044942 Promoter 0.8 EPDnew 600.7 +0.0 17 0.1 HNRNPL SP1 YY1 ZBTB33 JUND ZFHX2 ZFP69B RAD21 HNF4A EGR1 APOC4 APOC4-APOC2 APOC2
GH19J044945 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 0.7 +3.7 3712 1.8 HNRNPL GATAD2A REST TFE3 RBFOX2 RXRB SP1 GABPA CEBPA SOX13 APOC2 CLPTM1 ZNF180 ZNF234 ENSG00000269148 ZNF224 CLASRP ZNF155 FBXO46 NECTIN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APOC4-APOC2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for APOC4-APOC2 Gene

Genomic Locations for APOC4-APOC2 Gene
chr19:44,942,238-44,949,565
(GRCh38/hg38)
Size:
7,328 bases
Orientation:
Plus strand
chr19:45,445,495-45,452,822
(GRCh37/hg19)
Size:
7,328 bases
Orientation:
Plus strand

Genomic View for APOC4-APOC2 Gene

Genes around APOC4-APOC2 on UCSC Golden Path with GeneCards custom track
APOC4-APOC2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
APOC4-APOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOC4-APOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC4-APOC2 Gene

Proteins for APOC4-APOC2 Gene

  • Protein details for APOC4-APOC2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    K7ER74-K7ER74_HUMAN
    Recommended name:
    APOC4-APOC2 readthrough (NMD candidate)
    Protein Accession:
    K7ER74

    Protein attributes for APOC4-APOC2 Gene

    Size:
    178 amino acids
    Molecular mass:
    20049 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOC4-APOC2 Gene

Post-translational modifications for APOC4-APOC2 Gene

No Post-translational modifications

Other Protein References for APOC4-APOC2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for APOC4-APOC2 Gene

Domains & Families for APOC4-APOC2 Gene

Gene Families for APOC4-APOC2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for APOC4-APOC2 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with APOC4-APOC2: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for APOC4-APOC2 Gene

Function for APOC4-APOC2 Gene

Phenotypes From GWAS Catalog for APOC4-APOC2 Gene

Gene Ontology (GO) - Molecular Function for APOC4-APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IEA --
GO:0008289 lipid binding IBA --
GO:0016004 phospholipase activator activity IBA --
GO:0043274 phospholipase binding IBA --
GO:0060230 lipoprotein lipase activator activity IBA --
genes like me logo Genes that share ontologies with APOC4-APOC2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOC4-APOC2 Gene

Localization for APOC4-APOC2 Gene

Gene Ontology (GO) - Cellular Components for APOC4-APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034361 very-low-density lipoprotein particle IBA --
GO:0034362 low-density lipoprotein particle IBA --
GO:0034363 intermediate-density lipoprotein particle IBA --
GO:0034366 spherical high-density lipoprotein particle IBA --
GO:0042627 chylomicron IBA --
genes like me logo Genes that share ontologies with APOC4-APOC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for APOC4-APOC2 Gene

Pathways & Interactions for APOC4-APOC2 Gene

PathCards logo

SuperPathways for APOC4-APOC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for APOC4-APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006869 lipid transport IEA --
GO:0010518 positive regulation of phospholipase activity IBA --
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance IBA --
GO:0034382 chylomicron remnant clearance IBA --
genes like me logo Genes that share ontologies with APOC4-APOC2: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for APOC4-APOC2 Gene

Drugs & Compounds for APOC4-APOC2 Gene

No Compound Related Data Available

Transcripts for APOC4-APOC2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for APOC4-APOC2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B7A8_9606 lncRNA 1829 1

RefSeq: NR_037932,

URS00009B6185_9606 lncRNA 623 1

NONCODE: NONHSAT179799.1,

URS00009C1FC0_9606 lncRNA 460 1

NONCODE: NONHSAT179798.1,

APOC4-APOC2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for APOC4-APOC2 Gene

1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for APOC4-APOC2 Gene

No ASD Table

Relevant External Links for APOC4-APOC2 Gene

GeneLoc Exon Structure for
APOC4-APOC2

Expression for APOC4-APOC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for APOC4-APOC2 Gene

Protein differential expression in normal tissues from HIPED for APOC4-APOC2 Gene

This gene is overexpressed in Serum (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for APOC4-APOC2 Gene



Protein tissue co-expression partners for APOC4-APOC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APOC4-APOC2

genes like me logo Genes that share expression patterns with APOC4-APOC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOC4-APOC2 Gene

Orthologs for APOC4-APOC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC4-APOC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 95 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 60 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia APOC4 31
  • 59 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Apoc4 31
  • 57 (a)
OneToMany
Species where no ortholog for APOC4-APOC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for APOC4-APOC2 Gene

ENSEMBL:
Gene Tree for APOC4-APOC2 (if available)
TreeFam:
Gene Tree for APOC4-APOC2 (if available)

Paralogs for APOC4-APOC2 Gene

Paralogs for APOC4-APOC2 Gene

(2) SIMAP similar genes for APOC4-APOC2 Gene using alignment to 1 proteins:

  • K7ER74_HUMAN
genes like me logo Genes that share paralogs with APOC4-APOC2: view

Variants for APOC4-APOC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APOC4-APOC2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
2577 Pathogenic: APOLIPOPROTEIN C-II (HAMBURG); Apolipoprotein C2 deficiency 44,948,534(+) G/C SPLICE_DONOR_VARIANT
782056 Benign: Apolipoprotein C2 deficiency; not provided 44,948,697(+) G/C INTRON_VARIANT
894239 Uncertain Significance: Apolipoprotein C2 deficiency 44,946,051(+) G/C NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
894240 Uncertain Significance: Apolipoprotein C2 deficiency 44,946,071(+) G/A NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
894241 Uncertain Significance: Apolipoprotein C2 deficiency 44,948,690(+) T/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for APOC4-APOC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for APOC4-APOC2 Gene

Variant ID Type Subtype PubMed ID
nsv509747 CNV insertion 20534489

Variation tolerance for APOC4-APOC2 Gene

Gene Damage Index Score: 1.79; 33.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOC4-APOC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOC4-APOC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOC4-APOC2 Gene

Disorders for APOC4-APOC2 Gene

No disorders were found for APOC4-APOC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOC4-APOC2 Gene

Publications for APOC4-APOC2 Gene

  1. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre RN … Friedlander Y (Journal of lipid research 2015) 3
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 13
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 13

Products for APOC4-APOC2 Gene

Sources for APOC4-APOC2 Gene