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This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Mar 2017]
APOBEC3G (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3G) is a Protein Coding gene. Diseases associated with APOBEC3G include Hepatitis B and Hepatitis. Among its related pathways are HIV Life Cycle and Dual hijack model of Vif in HIV infection. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines. An important paralog of this gene is APOBEC3B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IBA,IDA | 11863358 |
GO:0003824 | catalytic activity | IEA | -- |
GO:0004126 | cytidine deaminase activity | TAS | 17121840 |
GO:0005515 | protein binding | IPI | 14528301 |
GO:0008270 | zinc ion binding | IDA | 11863358 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | IEA,IDA | 16699599 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA,IDA | 16527742 |
GO:0005829 | cytosol | TAS | -- |
GO:0030895 | apolipoprotein B mRNA editing enzyme complex | TAS | 17121840 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Life Cycle |
.65
|
.45
|
2 | Human cytomegalovirus infection | ||
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
4 | Dual hijack model of Vif in HIV infection | ||
5 | Integrated Breast Cancer Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002230 | positive regulation of defense response to virus by host | IDA | 17121840 |
GO:0002376 | immune system process | IEA | -- |
GO:0009972 | cytidine deamination | IDA | 16378963 |
GO:0010529 | negative regulation of transposition | IDA | 16527742 |
GO:0016032 | viral process | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | APOBEC3G 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | APOBEC3A 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17000736 | - | p.Arg256His | |||
rs17496046 | - | p.Gln275Glu | |||
rs8177832 | - | p.His186Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatitis b |
|
|
hepatitis |
|
|
human immunodeficiency virus infectious disease |
|
|
immune deficiency disease |
|
|
human immunodeficiency virus type 1 |
|