This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing e... See more...

Aliases for APOBEC3F Gene

Aliases for APOBEC3F Gene

  • Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3F 2 3 5
  • Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 3F 3 4
  • DNA DC->DU-Editing Enzyme APOBEC-3F 3 4
  • BK150C2.4.MRNA 2 3
  • ARP8 2 3
  • A3F 3 4
  • KA6 2 3
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3F 2
  • Apolipoprotein B Editing Enzyme Catalytic Polypeptide-Like 3F 3
  • Apolipoprotein B MRNA Editing Enzyme Cytidine Deaminase 3
  • Induced Upon T-Cell Activation 3
  • EC 3.5.4.38 4
  • APOBEC3F 5
  • EC 3.5.4 51

External Ids for APOBEC3F Gene

Previous GeneCards Identifiers for APOBEC3F Gene

  • GC22P036031
  • GC22P036051
  • GC22P037679
  • GC22P037761
  • GC22P039436
  • GC22P022404
  • GC22P039040

Summaries for APOBEC3F Gene

Entrez Gene Summary for APOBEC3F Gene

  • This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOBEC3F Gene

APOBEC3F (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3F) is a Protein Coding gene. Diseases associated with APOBEC3F include Immune Deficiency Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Human cytomegalovirus infection. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines. An important paralog of this gene is APOBEC3D.

UniProtKB/Swiss-Prot Summary for APOBEC3F Gene

  • DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Gene Wiki entry for APOBEC3F Gene

Additional gene information for APOBEC3F Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APOBEC3F Gene

Genomics for APOBEC3F Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for APOBEC3F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J039039 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 606 +22.2 22193 3 PRDM10 IKZF1 ZNF692 ZIC2 PATZ1 HDAC1 POLR2A ZNF341 ZFX EED APOBEC3F APOBEC3G piR-46491-001 piR-46491-002 APOBEC3D
GH22J039017 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 605.4 -1.0 -1009 1.5 CTCF USF1 POLR2A POU5F1 APOBEC3D APOBEC3C APOBEC3F ENSG00000284554
GH22J039020 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.7 +0.5 539 0.1 APOBEC3D APOBEC3F HSALNG0135466 APOBEC3C ENSG00000284554
GH22J038174 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 -840.3 -840272 8.7 SP1 CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 LEF1 SOX13 IKZF1 PLA2G6 DDX17 MAFF ENSG00000228274 CSNK1E ANKRD54 CBY1 ENSG00000230912 GGA1 TMEM184B
GH22J038567 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.5 -449.7 -449693 4.7 ZNF629 PRDM10 ZNF692 PRDM1 ZSCAN4 ZNF24 PATZ1 POLR2A BRD9 ZNF501 DMC1 LOC105373031 lnc-FAM227A-2 FAM227A DDX17 ENSG00000230149 ENSG00000230912 ENSG00000273076 SNORD83B ENSG00000272669
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APOBEC3F on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for APOBEC3F

Top Transcription factor binding sites by QIAGEN in the APOBEC3F gene promoter:
  • E47
  • Evi-1
  • Hand1
  • ZID

Genomic Locations for APOBEC3F Gene

Genomic Locations for APOBEC3F Gene
chr22:39,019,081-39,055,972
(GRCh38/hg38)
Size:
36,892 bases
Orientation:
Plus strand
chr22:39,436,609-39,451,977
(GRCh37/hg19)
Size:
15,369 bases
Orientation:
Plus strand

Genomic View for APOBEC3F Gene

Genes around APOBEC3F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOBEC3F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOBEC3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBEC3F Gene

Proteins for APOBEC3F Gene

  • Protein details for APOBEC3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUX4-ABC3F_HUMAN
    Recommended name:
    DNA dC->dU-editing enzyme APOBEC-3F
    Protein Accession:
    Q8IUX4
    Secondary Accessions:
    • B0QYD4
    • Q45F03
    • Q6ICH3
    • Q7Z2N2
    • Q7Z2N5

    Protein attributes for APOBEC3F Gene

    Size:
    373 amino acids
    Molecular mass:
    45020 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Binds HIV-1 Vif. In the absence of Vif protein, specifically packaged into HIV-1 virions. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with AGO1, AGO2 and AGO3.
    Miscellaneous:
    • It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.
    • [Isoform 2]: May be due to a competing donor splice site.

    Three dimensional structures from OCA and Proteopedia for APOBEC3F Gene

    Alternative splice isoforms for APOBEC3F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOBEC3F Gene

Selected DME Specific Peptides for APOBEC3F Gene

Q8IUX4:
  • CFLSWFC
  • DSKLQEIL
  • WLCYEVK

Post-translational modifications for APOBEC3F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOBEC3F Gene

Domains & Families for APOBEC3F Gene

Gene Families for APOBEC3F Gene

Protein Domains for APOBEC3F Gene

InterPro:
Blocks:
  • Cytidine/deoxycytidylate deaminase, zinc-binding region
  • APOBEC-like, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for APOBEC3F Gene

GenScript: Design optimal peptide antigens:
  • Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F (ABC3F_HUMAN)
  • Apolipoprotein B mRNA editing enzyme cytidine deaminase (F2YHL7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IUX4

UniProtKB/Swiss-Prot:

ABC3F_HUMAN :
  • The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Domain:
  • The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with APOBEC3F: view

Function for APOBEC3F Gene

Molecular function for APOBEC3F Gene

UniProtKB/Swiss-Prot Function:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2'-deoxycytidine in a single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in a single-stranded DNA + NH4(+); Xref=Rhea:RHEA:50948, Rhea:RHEA-COMP:12846, Rhea:RHEA-COMP:12847, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:85452, ChEBI:CHEBI:133902; EC=3.5.4.38;.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFN-alpha.
UniProtKB/Swiss-Prot EnzymeRegulation:
Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents its incorporation into progeny virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome.

Enzyme Numbers (IUBMB) for APOBEC3F Gene

Phenotypes From GWAS Catalog for APOBEC3F Gene

Gene Ontology (GO) - Molecular Function for APOBEC3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 11863358
GO:0003824 catalytic activity IEA --
GO:0004126 cytidine deaminase activity IDA 17121840
GO:0005515 protein binding IPI 16699599
GO:0008270 zinc ion binding IDA 11863358
genes like me logo Genes that share ontologies with APOBEC3F: view
genes like me logo Genes that share phenotypes with APOBEC3F: view

Animal Model Products

CRISPR Products

miRNA for APOBEC3F Gene

miRTarBase miRNAs that target APOBEC3F

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOBEC3F

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOBEC3F Gene

Localization for APOBEC3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3F Gene

Cytoplasm. Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOBEC3F gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for APOBEC3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA,IDA 16699599
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA,IDA 16527742
GO:0030895 apolipoprotein B mRNA editing enzyme complex TAS 17121840
GO:1990904 ribonucleoprotein complex IDA 16699599
genes like me logo Genes that share ontologies with APOBEC3F: view

Pathways & Interactions for APOBEC3F Gene

PathCards logo

SuperPathways for APOBEC3F Gene

genes like me logo Genes that share pathways with APOBEC3F: view

Pathways by source for APOBEC3F Gene

1 KEGG pathway for APOBEC3F Gene

Gene Ontology (GO) - Biological Process for APOBEC3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IDA 17121840
GO:0002376 immune system process IEA --
GO:0009972 cytidine deamination IEA --
GO:0010529 negative regulation of transposition IDA 16527742
GO:0016553 base conversion or substitution editing IDA 17121840
genes like me logo Genes that share ontologies with APOBEC3F: view

No data available for SIGNOR curated interactions for APOBEC3F Gene

Drugs & Compounds for APOBEC3F Gene

(4) Drugs for APOBEC3F Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Experimental, Investigational Pharma 1335
Ammonia Approved Pharma 0
Water Approved Pharma 0
Uridine Experimental, Investigational Pharma 0

(1) Additional Compounds for APOBEC3F Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APOBEC3F: view

Transcripts for APOBEC3F Gene

mRNA/cDNA for APOBEC3F Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOBEC3F

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC3F Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5:
SP6:
SP7: - - - - - - - - - - - -
SP8: -
SP9: -
SP10: - - -

Relevant External Links for APOBEC3F Gene

GeneLoc Exon Structure for
APOBEC3F

Expression for APOBEC3F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for APOBEC3F Gene

Protein differential expression in normal tissues from HIPED for APOBEC3F Gene

This gene is overexpressed in Ovary (16.0), Lung (13.2), Blymphocyte (11.2), and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APOBEC3F Gene



Protein tissue co-expression partners for APOBEC3F Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APOBEC3F

SOURCE GeneReport for Unigene cluster for APOBEC3F Gene:

Hs.659809

mRNA Expression by UniProt/SwissProt for APOBEC3F Gene:

Q8IUX4-ABC3F_HUMAN
Tissue specificity: Widely expressed. Highly expressed in ovary.

Evidence on tissue expression from TISSUES for APOBEC3F Gene

  • Spleen(4.3)
  • Pancreas(4)
  • Blood(2.6)
  • Kidney(2)
genes like me logo Genes that share expression patterns with APOBEC3F: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOBEC3F Gene

Orthologs for APOBEC3F Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for APOBEC3F Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia APOBEC3F 30
  • 98.48 (n)
Species where no ortholog for APOBEC3F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for APOBEC3F Gene

ENSEMBL:
Gene Tree for APOBEC3F (if available)
TreeFam:
Gene Tree for APOBEC3F (if available)
Aminode:
Evolutionary constrained regions (ECRs) for APOBEC3F: view image

Paralogs for APOBEC3F Gene

(11) SIMAP similar genes for APOBEC3F Gene using alignment to 3 proteins:

  • ABC3F_HUMAN
  • F2YHL7_HUMAN
  • M4VR43_HUMAN

Pseudogenes.org Pseudogenes for APOBEC3F Gene

genes like me logo Genes that share paralogs with APOBEC3F: view

Variants for APOBEC3F Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APOBEC3F Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
731745 Likely Benign: not provided 39,045,429(+) A/C MISSENSE_VARIANT
757565 Likely Benign: not provided 39,052,137(+) C/T SYNONYMOUS_VARIANT
774749 Benign: not provided 39,052,610(+) A/G MISSENSE_VARIANT
781619 Benign: not provided 39,049,431(+) G/A SYNONYMOUS_VARIANT
781910 Benign: not provided 39,052,270(+) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for APOBEC3F Gene

Structural Variations from Database of Genomic Variants (DGV) for APOBEC3F Gene

Variant ID Type Subtype PubMed ID
esv22523 CNV gain 19812545
esv2673637 CNV deletion 23128226
esv2676044 CNV deletion 23128226
esv2724242 CNV deletion 23290073
esv2724243 CNV deletion 23290073
esv3647751 CNV gain 21293372
esv3647755 CNV loss 21293372
esv3647756 CNV gain 21293372
esv3647757 CNV loss 21293372
esv3647758 CNV loss 21293372
nsv1139065 CNV deletion 24896259
nsv522083 CNV loss 19592680
nsv834196 CNV loss 17160897
nsv964631 CNV duplication 23825009

Variation tolerance for APOBEC3F Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOBEC3F Gene

Human Gene Mutation Database (HGMD)
APOBEC3F
SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOBEC3F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3F Gene

Disorders for APOBEC3F Gene

MalaCards: The human disease database

(2) MalaCards diseases for APOBEC3F Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immune deficiency disease
  • primary immunodeficiency disease
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with APOBEC3F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APOBEC3F Gene

Publications for APOBEC3F Gene

  1. APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G. (PMID: 17121840) Holmes RK … Malim MH (The Journal of biological chemistry 2007) 2 3 23
  2. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PMID: 16699599) Wichroski MJ … Rana TM (PLoS pathogens 2006) 3 4 23
  3. A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins. (PMID: 15152192) Wiegand HL … Cullen BR (The EMBO journal 2004) 3 4 23
  4. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PMID: 11863358) Jarmuz A … Navaratnam N (Genomics 2002) 2 3 4
  5. APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages. (PMID: 23097438) Chaipan C … Pathak VK (Journal of virology 2013) 3 4

Products for APOBEC3F Gene

Sources for APOBEC3F Gene