Aliases for APOBEC3D Gene
- Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3D 2 3 5
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3E Pseudogene 2 3
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3D 2 3
- DNA DC->DU-Editing Enzyme APOBEC-3D 3 4
- A3D 3 4
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3D (Putative) 2
External Ids for APOBEC3D Gene
Previous HGNC Symbols for APOBEC3D Gene
Previous GeneCards Identifiers for APOBEC3D Gene
This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOBEC3D Gene
APOBEC3D (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3D) is a Protein Coding gene. Among its related pathways are Human cytomegalovirus infection. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines. An important paralog of this gene is ENSG00000284554.
UniProtKB/Swiss-Prot Summary for APOBEC3D Gene
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.