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This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing e... See more...
Aliases for APOBEC3B Gene
Aliases for APOBEC3B Gene
- Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B 2 3 5
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3B 2 3
- DNA DC->DU-Editing Enzyme APOBEC-3B 3 4
- Phorbolin-1-Related Protein 3 4
- Phorbolin-2/3 3 4
- Phorbolin 3 2 3
- PHRBNL 2 3
- A3B 3 4
- Probable DNA DC->DU-Editing Enzyme APOBEC-3B 3
- Cytidine Deaminase 3
External Ids for APOBEC3B Gene
- HGNC: 17352
- Entrez Gene: 9582
- Ensembl: ENSG00000179750
- OMIM: 607110
- UniProtKB: Q9UH17
Previous GeneCards Identifiers for APOBEC3B Gene
- GC22P035992
- GC22P037621
- GC22P037702
- GC22P039378
- GC22P022346
Summaries for APOBEC3B Gene
-
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for APOBEC3B Gene
APOBEC3B (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B) is a Protein Coding gene. Diseases associated with APOBEC3B include Human T-Cell Leukemia Virus Type 1 and Bone Leiomyosarcoma. Among its related pathways are Gene Expression and mRNA Editing- C to U Conversion. Gene Ontology (GO) annotations related to this gene include deoxycytidine deaminase activity. An important paralog of this gene is APOBEC3D.
UniProtKB/Swiss-Prot Summary for APOBEC3B Gene
-
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Additional gene information for APOBEC3B Gene
- HGNC(17352)
- Entrez Gene(9582)
- Ensembl(ENSG00000179750)
- OMIM(607110)
- UniProtKB(Q9UH17)
- Open Targets Platform(ENSG00000179750)
- Monarch Initiative
- Search for APOBEC3B at DataMed
- Search for APOBEC3B at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APOBEC3B Gene
Genomics for APOBEC3B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for APOBEC3B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around APOBEC3B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for APOBEC3B
- Top Transcription factor binding sites by QIAGEN in the APOBEC3B gene promoter:
-
- Arnt
- Evi-1
- LCR-F1
- Max1
- MAZR
- Msx-1
- SREBP-1a
- SREBP-1b
- SREBP-1c
- USF1
Genomic Locations for APOBEC3B Gene
Genomic Locations for APOBEC3B Gene
- chr22:38,982,347-38,992,804
- (GRCh38/hg38)
- Size:
- 10,458 bases
- Orientation:
- Plus strand
- chr22:39,378,352-39,388,809
- (GRCh37/hg19)
- Size:
- 10,458 bases
- Orientation:
- Plus strand
Genomic View for APOBEC3B Gene
Genes around APOBEC3B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by HGNC
- 22q13.1 by Entrez Gene
- 22q13.1 by Ensembl
APOBEC3B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOBEC3B Gene
Proteins for APOBEC3B Gene
-
Protein details for APOBEC3B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UH17-ABC3B_HUMAN
- Recommended name:
- DNA dC->dU-editing enzyme APOBEC-3B
- Protein Accession:
- Q9UH17
- B0QYD2
- O95618
- Q20WL1
- Q5IFJ4
- Q7Z2N3
- Q7Z6D6
- Q9UE74
Protein attributes for APOBEC3B Gene
- Size:
- 382 amino acids
- Molecular mass:
- 45924 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1.
- SequenceCaution:
-
- Sequence=AAD00089.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAD00090.1; Type=Frameshift; Note=Frameshifts result in two separate ORFs termed phorbolins 2 and 3.; Evidence={ECO:0000305};
- Miscellaneous:
-
- It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.
- [Isoform 2]: May be due to a competing donor splice site.
Three dimensional structures from OCA and Proteopedia for APOBEC3B Gene
Protein Expression for APOBEC3B Gene
Selected DME Specific Peptides for APOBEC3B Gene
- Q9UH17:
-
- EHSQALSGRL
- CFLSWFC
- PFQPWDGL
- WLCYEVK
Post-translational modifications for APOBEC3B Gene
Other Protein References for APOBEC3B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences APOBEC3B Antibody (LS-B12051) and APOBEC3B Antibody (LS-A11154)
- Creative Diagnostics Anti-APOBEC3B monoclonal antibody
- Creative Biolabs Recombinant Rabbit Anti-APOBEC3B Antibody (5210-87-13)
- Novus Biologicals Antibodies for APOBEC3B
-
Abcam antibodies for APOBEC3B
- Invitrogen Antibodies for APOBEC3B (AFLGC-APOBEC3B)
-
Boster Bio Antibodies for APOBEC3B
-
Custom Antibody ServicesProSci Antibodies for APOBEC3B
- Sino Biological Antibodies for APOBEC3B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for APOBEC3B
- Origene Custom Protein Services for APOBEC3B
- antibodies-online: Show 5 available APOBEC3B Proteins ranked by validation data
- Compare Top APOBEC3B Proteins
-
Quality Products:
-
Abcam proteins for APOBEC3B
Domains & Families for APOBEC3B Gene
Gene Families for APOBEC3B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for APOBEC3B Gene
- InterPro:
- Blocks:
-
- Cytidine/deoxycytidylate deaminase, zinc-binding region
- APOBEC-like, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for APOBEC3B Gene
- GenScript: Design optimal peptide antigens:
-
- Phorbolin-2/3 (ABC3B_HUMAN)
- BK150C2.2 protein (Q20WL1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UH17UniProtKB/Swiss-Prot:
ABC3B_HUMAN :- The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.
- Belongs to the cytidine and deoxycytidylate deaminase family.
- Domain:
-
- The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.
- Family:
-
- Belongs to the cytidine and deoxycytidylate deaminase family.
Function for APOBEC3B Gene
Molecular function for APOBEC3B Gene
- UniProtKB/Swiss-Prot Function:
- DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 2'-deoxycytidine in a single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in a single-stranded DNA + NH4(+); Xref=Rhea:RHEA:50948, Rhea:RHEA-COMP:12846, Rhea:RHEA-COMP:12847, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:85452, ChEBI:CHEBI:133902; EC=3.5.4.38;.
- UniProtKB/Swiss-Prot Induction:
- Phorbol 12-myristate 13-acetate (PMA) induces overexpression in keratinocytes. Up-regulated by IFN-alpha.
Enzyme Numbers (IUBMB) for APOBEC3B Gene
Phenotypes From GWAS Catalog for APOBEC3B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IBA | 21873635 |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004126 | cytidine deaminase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 31217276 |
| GO:0008270 | zinc ion binding | IEA | -- |
Phenotypes for APOBEC3B Gene
- MGI mutant phenotypes for APOBEC3B:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for APOBEC3B:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells
- Increased gamma-H2AX phosphorylation
- Strongly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Decreased Sindbis virus (SINV) infection
- Increased homologous recombination repair frequency
Animal Models for APOBEC3B Gene
- MGI Knock Outs for APOBEC3B:
-
- Apobec3 Apobec3<tm1Msn>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for APOBEC3B - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for APOBEC3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOBEC3B
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC3B
miRNA for APOBEC3B Gene
- miRTarBase miRNAs that target APOBEC3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOBEC3B
- Browse OriGene Inhibitory RNA Products For APOBEC3B
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Clone Products
- Applied Biological Materials (abm): Clones for APOBEC3B - Select products 50% OFF >
- * APOBEC3B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for APOBEC3B
- Addgene plasmids for APOBEC3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOBEC3B
Cell Line Products
-
Horizon Cell Lines for APOBEC3B
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APOBEC3B Gene
Localization for APOBEC3B Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| cytosol | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | IBA | 21873635 |
| GO:0005634 | nucleus | IBA,IDA | 16699599 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
Pathways & Interactions for APOBEC3B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Editing- C to U Conversion |
.82
|
|
| 2 | Human cytomegalovirus infection | ||
| 3 | Gene Expression |
.48
|
|
Pathways by source for APOBEC3B Gene
4 Reactome pathways for APOBEC3B Gene
1 KEGG pathway for APOBEC3B Gene
Interacting Proteins for APOBEC3B Gene
Selected Interacting proteins:
Q9UH17-ABC3B_HUMAN
ENSP00000327459
for APOBEC3B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for APOBEC3B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0009972 | cytidine deamination | IEA | -- |
| GO:0010529 | negative regulation of transposition | IDA | 16527742 |
| GO:0016554 | cytidine to uridine editing | IBA | 21873635 |
| GO:0045087 | innate immune response | IEA | -- |
No data available for SIGNOR curated interactions for APOBEC3B Gene
Transcripts for APOBEC3B Gene
mRNA/cDNA for APOBEC3B Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000407298 1282 nts (view in UCSC)
- ENST00000333467 1590 nts (view in UCSC)
- ENST00000402182 1844 nts (view in UCSC)
- ENST00000335760 1359 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for APOBEC3B - Select products 50% OFF >
- * APOBEC3B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for APOBEC3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOBEC3B
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOBEC3B
- Browse OriGene Inhibitory RNA Products For APOBEC3B
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Clone Products
- Applied Biological Materials (abm): Clones for APOBEC3B - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for APOBEC3B
- Addgene plasmids for APOBEC3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOBEC3B
Relevant External Links for APOBEC3B Gene
- GeneLoc Exon Structure for
- APOBEC3B
Expression for APOBEC3B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
- Epiblast Stem Cell line 5
- Inner Cell Mass (Early Embryonic Tissues)
- Blood (Hematopoietic System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Adipose (Muscoskeletal System)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for APOBEC3B Gene
This gene is overexpressed in Whole Blood (x16.7).
This gene is overexpressed in Blymphocyte (30.5), Heart (26.9), and Peripheral blood mononuclear cells (11.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APOBEC3B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APOBEC3B
SOURCE GeneReport for Unigene cluster for APOBEC3B Gene:
Hs.226307mRNA Expression by UniProt/SwissProt for APOBEC3B Gene:
Q9UH17-ABC3B_HUMAN
Tissue specificity:
Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues.
Evidence on tissue expression from TISSUES for APOBEC3B Gene
- Skin(4.4)
- Blood(2.4)
Primer Products
-
OriGene qPCR primer pairs for APOBEC3B
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APOBEC3B Gene
Orthologs for APOBEC3B Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | APOBEC3B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | APOBEC3B 30 |
|
||
| APOBEC3A 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Apobec3b 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Apobec3 30 17 |
|
||
| Dog (Canis familiaris) |
Mammalia | APOBEC3H 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for APOBEC3B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for APOBEC3B Gene
- ENSEMBL:
- Gene Tree for APOBEC3B (if available)
- TreeFam:
- Gene Tree for APOBEC3B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for APOBEC3B: view image
Paralogs for APOBEC3B Gene
Paralogs for APOBEC3B Gene
(10) SIMAP similar genes for APOBEC3B Gene using alignment to 3 proteins:
- ABC3B_HUMAN
- B0QYD3_HUMAN
- W0HJ78_HUMAN
Pseudogenes.org Pseudogenes for APOBEC3B Gene
Variants for APOBEC3B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APOBEC3B Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 777709 | Benign: not provided | 38,989,505(+) | T/C | SYNONYMOUS_VARIANT | |
| 778951 | Benign: not provided | 38,984,126(+) | C/T | SYNONYMOUS_VARIANT | |
| rs1053813 | - | p.Arg351His | |||
| rs17000697 | - | p.Ser109Ala | |||
| rs2076109 | - | p.Lys62Glu |
Residual Variation Intolerance Score:
99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.98;
74.77% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for APOBEC3B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3B Gene
Disorders for APOBEC3B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| human t-cell leukemia virus type 1 |
|
|
| bone leiomyosarcoma |
|
|
| recessive dystrophic epidermolysis bullosa |
|
|
Search APOBEC3B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for APOBEC3B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for APOBEC3B Gene
Publications for APOBEC3B Gene
- Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1. (PMID: 10469298) Madsen P … Celis JE (The Journal of investigative dermatology 1999) 2 3 4 23
- APOBEC3B deletion and risk of HIV-1 acquisition. (PMID: 19698078) An P … Winkler CA (The Journal of infectious diseases 2009) 3 23 41
- Population stratification of a common APOBEC gene deletion polymorphism. (PMID: 17447845) Kidd JM … Eichler EE (PLoS genetics 2007) 3 23 41
- An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PMID: 11863358) Jarmuz A … Navaratnam N (Genomics 2002) 2 3 4
- HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. (PMID: 22915799) Phalora PK … Malim MH (Journal of virology 2012) 3 4
ExternalLinks
Products for APOBEC3B Gene
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- Invitrogen Antibodies for APOBEC3B (AFLGC-APOBEC3B)
- VectorBuilder Custom and pre-made DNA vectors for APOBEC3B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for APOBEC3B (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for APOBEC3B (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for APOBEC3B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for APOBEC3B
- Addgene plasmids for APOBEC3B
- antibodies-online: Show 14 available APOBEC3B Antibodies ranked by validation data
- Compare Top APOBEC3B Antibodies
- antibodies-online: Search results for available APOBEC3B related products ranked by validation data
- antibodies-online: Show 5 available APOBEC3B Proteins ranked by validation data
- Compare Top APOBEC3B Proteins
- Quality Products:
- Horizon Cell Lines for APOBEC3B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOBEC3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOBEC3B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for APOBEC3B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOBEC3B
- Boster Bio Antibodies for APOBEC3B
- Browse Boster Bio ELISA Kits
Sources for APOBEC3B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB