Aliases for APOBEC3B Gene
Aliases for APOBEC3B Gene
- Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B 2 3 5
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3B 2 3
- Phorbolin-1-Related Protein 3 4
- Phorbolin-2/3 3 4
- Phorbolin 3 2 3
- A3B 3 4
- Probable DNA DC->DU-Editing Enzyme APOBEC-3B 3
- DNA DC->DU-Editing Enzyme APOBEC-3B 3
- Cytidine Deaminase 3
External Ids for APOBEC3B Gene
- HGNC: 17352
- Entrez Gene: 9582
- Ensembl: ENSG00000179750
- OMIM: 607110
- UniProtKB: Q9UH17
Previous GeneCards Identifiers for APOBEC3B Gene
- GC22P035992
- GC22P037621
- GC22P037702
- GC22P039378
- GC22P022346
Summaries for APOBEC3B Gene
-
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for APOBEC3B Gene
APOBEC3B (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B) is a Protein Coding gene. Diseases associated with APOBEC3B include Human T-Cell Leukemia Virus Type 1. Among its related pathways are Formation of the Editosome and Gene Expression. Gene Ontology (GO) annotations related to this gene include deoxycytidine deaminase activity. An important paralog of this gene is ENSG00000284554.
UniProtKB/Swiss-Prot for APOBEC3B Gene
-
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Additional gene information for APOBEC3B Gene
- Monarch Initiative
- Search for APOBEC3B at DataMed
- Search for APOBEC3B at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3B Gene
Genomics for APOBEC3B Gene
GeneHancer (GH) Regulatory Elements for APOBEC3B Gene
Promoters and enhancers for APOBEC3B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around APOBEC3B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for APOBEC3B Gene
Genomic Locations for APOBEC3B Gene
- chr22:38,982,347-38,992,804
- (GRCh38/hg38)
- Size:
- 10,458 bases
- Orientation:
- Plus strand
- chr22:39,378,352-39,388,809
- (GRCh37/hg19)
Genomic View for APOBEC3B Gene
Genes around APOBEC3B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by Entrez Gene
- 22q13.1 by HGNC
- 22q13.1 by Ensembl
APOBEC3B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOBEC3B Gene
Proteins for APOBEC3B Gene
-
Protein details for APOBEC3B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UH17-ABC3B_HUMAN
- Recommended name:
- DNA dC->dU-editing enzyme APOBEC-3B
- Protein Accession:
- Q9UH17
- B0QYD2
- O95618
- Q20WL1
- Q5IFJ4
- Q7Z2N3
- Q7Z6D6
- Q9UE74
Protein attributes for APOBEC3B Gene
- Size:
- 382 amino acids
- Molecular mass:
- 45924 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1.
- Miscellaneous:
-
- It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.
- SequenceCaution:
-
- Sequence=AAD00089.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD00090.1; Type=Frameshift; Positions=59, 134; Note=Frameshifts result in two separate ORFs termed phorbolins 2 and 3.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for APOBEC3B Gene
Protein Expression for APOBEC3B Gene
Post-translational modifications for APOBEC3B Gene
Other Protein References for APOBEC3B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for APOBEC3B
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-
Boster Bio Antibodies for APOBEC3B
-
Custom Antibody ServicesProSci Antibodies for APOBEC3B
- Sino Biological Antibodies for APOBEC3B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for APOBEC3B
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- Search GeneTex for Proteins for APOBEC3B
Assay Products
No data available for DME Specific Peptides for APOBEC3B Gene
Domains & Families for APOBEC3B Gene
Gene Families for APOBEC3B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for APOBEC3B Gene
Suggested Antigen Peptide Sequences for APOBEC3B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UH17UniProtKB/Swiss-Prot:
ABC3B_HUMAN :- The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.
- Belongs to the cytidine and deoxycytidylate deaminase family.
- Domain:
-
- The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.
- Family:
-
- Belongs to the cytidine and deoxycytidylate deaminase family.
Function for APOBEC3B Gene
Molecular function for APOBEC3B Gene
- UniProtKB/Swiss-Prot Function:
- DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cytidine + H(2)O = uridine + NH(3).
- UniProtKB/Swiss-Prot Induction:
- Phorbol 12-myristate 13-acetate (PMA) induces overexpression in keratinocytes. Up-regulated by IFN-alpha.
Enzyme Numbers (IUBMB) for APOBEC3B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IBA,IEA | -- |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004126 | cytidine deaminase activity | IBA | -- |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for APOBEC3B Gene
- MGI mutant phenotypes for APOBEC3B:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for APOBEC3B:
-
- Decreased homologous recombination repair frequency
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Increased Sindbis virus (SINV) infection
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for APOBEC3B Gene
- MGI Knock Outs for APOBEC3B:
-
- Apobec3 Apobec3<tm1Msn>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC3B
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- genomics-online: gRNA clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Applied Biological Materials CRISPR for APOBEC3B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC3B
- GenScript: Design CRISPR guide RNA sequences for APOBEC3B
miRNA for APOBEC3B Gene
- miRTarBase miRNAs that target APOBEC3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOBEC3B
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOBEC3B
- genomics-online: shRNA clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Clone Products
- VectorBuilder custom plasmid, inducible vectors for APOBEC3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOBEC3B
- genomics-online: cdna clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- orf clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Applied Biological Materials Clones for APOBEC3B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for APOBEC3B
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APOBEC3B Gene
Localization for APOBEC3B Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 16699599 |
| GO:0005737 | cytoplasm | IBA | -- |
Pathways & Interactions for APOBEC3B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Formation of the Editosome |
.82
|
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for APOBEC3B Gene
4 Reactome pathways for APOBEC3B Gene
Interacting Proteins for APOBEC3B Gene
GPS-Prot Interaction Network for APOBEC3B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010529 | negative regulation of transposition | IDA | 16527742 |
| GO:0016554 | cytidine to uridine editing | IBA | -- |
| GO:0045087 | innate immune response | IEA | -- |
| GO:0051607 | defense response to virus | IDA,IEA | 22457529 |
| GO:0080111 | DNA demethylation | IBA | -- |
No data available for SIGNOR curated interactions for APOBEC3B Gene
Transcripts for APOBEC3B Gene
mRNA/cDNA for APOBEC3B Gene
- (55) Selected AceView cDNA sequences:
- (9) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000333467 1533 bps (uc003awo.3)
- ENST00000335760 1359 bps (uc062ejf.1)
- ENST00000402182 1844 bps (uc062eje.1)
- ENST00000407298 1282 bps (uc003awp.3)
Unigene Clusters for APOBEC3B Gene
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOBEC3B
- genomics-online: gRNA clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Applied Biological Materials CRISPR for APOBEC3B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC3B
- GenScript: Design CRISPR guide RNA sequences for APOBEC3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOBEC3B
- Browse OriGene Inhibitory RNA Products For APOBEC3B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOBEC3B
- genomics-online: shRNA clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Clone Products
- VectorBuilder custom plasmid, inducible vectors for APOBEC3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOBEC3B
- genomics-online: cdna clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- orf clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pCMV6-XL5
- pCMV6-Entry
- pPB-N-His
- pPB-C-His
- pPM-C-HA
- pPM-C-His
- pPB-His-GST
- pPB-His-MBP
- pcDNA3.1+C-(K)-DYK
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Applied Biological Materials Clones for APOBEC3B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for APOBEC3B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
- Epiblast Stem Cell line 5
- Inner Cell Mass (Early Embryonic Tissues)
- Blood (Hematopoietic System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Adipose (Muscoskeletal System)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for APOBEC3B Gene
This gene is overexpressed in Whole Blood (x16.7).
This gene is overexpressed in Blymphocyte (30.5), Heart (26.9), and Peripheral blood mononuclear cells (11.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APOBEC3B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of APOBEC3B Gene:
APOBEC3BSOURCE GeneReport for Unigene cluster for APOBEC3B Gene:
Hs.226307mRNA Expression by UniProt/SwissProt for APOBEC3B Gene:
Q9UH17-ABC3B_HUMAN
Tissue specificity:
Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues.
Evidence on tissue expression from TISSUES for APOBEC3B Gene
- Skin(4)
Primer Products
-
OriGene qPCR primer pairs for APOBEC3B
- genomics-online: primer clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
-
Recommended
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- pPM-N-D-C-HA
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- pDONR223
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- pCMV6-XL5
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- pPB-N-His
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- pcDNA3.1+C-(K)-DYK
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Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APOBEC3B Gene
Orthologs for APOBEC3B Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | APOBEC3B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | APOBEC3B 33 |
|
||
| APOBEC3A 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Apobec3b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Apobec3 16 33 |
|
||
| dog (Canis familiaris) |
Mammalia | APOBEC3H 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for APOBEC3B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for APOBEC3B Gene
- ENSEMBL:
- Gene Tree for APOBEC3B (if available)
- TreeFam:
- Gene Tree for APOBEC3B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for APOBEC3B: view image
Paralogs for APOBEC3B Gene
Paralogs for APOBEC3B Gene
(10) SIMAP similar genes for APOBEC3B Gene using alignment to 3 proteins:
- ABC3B_HUMAN
- B0QYD3_HUMAN
- W0HJ78_HUMAN
Pseudogenes.org Pseudogenes for APOBEC3B Gene
Variants for APOBEC3B Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000852159 | -- | 38,985,105(+) | G/A | intron_variant | |
| rs1000947215 | -- | 38,991,436(+) | T/C | coding_sequence_variant, synonymous_variant | |
| rs1001509097 | -- | 38,985,419(+) | G/A | intron_variant | |
| rs1001538797 | -- | 38,988,523(+) | A/C/G | intron_variant | |
| rs1001877588 | -- | 38,989,999(+) | G/C | intron_variant |
Residual Variation Intolerance Score:
99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.98;
74.77% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for APOBEC3B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3B Gene
Disorders for APOBEC3B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| human t-cell leukemia virus type 1 |
|
|
Search APOBEC3B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for APOBEC3B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for APOBEC3B Gene
Publications for APOBEC3B Gene
- Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1. (PMID: 10469298) Madsen P … Celis JE (The Journal of investigative dermatology 1999) 2 3 4 22 58
- APOBEC3B deletion and risk of HIV-1 acquisition. (PMID: 19698078) An P … Winkler CA (The Journal of infectious diseases 2009) 3 22 44 58
- Population stratification of a common APOBEC gene deletion polymorphism. (PMID: 17447845) Kidd JM … Eichler EE (PLoS genetics 2007) 3 22 44 58
- An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PMID: 11863358) Jarmuz A … Navaratnam N (Genomics 2002) 2 3 4 58
- APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1. (PMID: 22457529) Ooms M … Münk C (Journal of virology 2012) 3 4 58
Products for APOBEC3B Gene
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- Yeast expression
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- orf clones - Search results for 51 available BAF53A gene related products
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- genomics-online: primer clones - Search results for 51 available BAF53A gene related products
- Overview of 51 available BAF53A gene related products
- Recommended
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- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
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Sources for APOBEC3B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio