Aliases for APOBEC3A Gene
External Ids for APOBEC3A Gene
Previous GeneCards Identifiers for APOBEC3A Gene
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for APOBEC3A Gene
APOBEC3A (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3A) is a Protein Coding gene. Diseases associated with APOBEC3A include Plantar Wart and Psoriasis. Among its related pathways are Human cytomegalovirus infection and Formation of the Editosome. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines and deoxycytidine deaminase activity. An important paralog of this gene is APOBEC3B.
UniProtKB/Swiss-Prot Summary for APOBEC3A Gene
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.