Aliases for APOA5 Gene
External Ids for APOA5 Gene
Previous GeneCards Identifiers for APOA5 Gene
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]
GeneCards Summary for APOA5 Gene
APOA5 (Apolipoprotein A5) is a Protein Coding gene. Diseases associated with APOA5 include Hyperlipoproteinemia, Type V and Hypertriglyceridemia, Familial. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Statin Pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and heparin binding. An important paralog of this gene is APOA4.
UniProtKB/Swiss-Prot Summary for APOA5 Gene
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed:17326667).