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Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is n... See more...
Aliases for APOA4 Gene
Aliases for APOA4 Gene
External Ids for APOA4 Gene
- HGNC: 602
- NCBI Entrez Gene: 337
- Ensembl: ENSG00000110244
- OMIM®: 107690
- UniProtKB/Swiss-Prot: P06727
Previous GeneCards Identifiers for APOA4 Gene
- GC11M119044
- GC11M118203
- GC11M116725
- GC11M116229
- GC22P9A0027
- GC11M116198
- GC11M116692
- GC11M112623
Summaries for APOA4 Gene
-
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOA4 Gene
APOA4 (Apolipoprotein A4) is a Protein Coding gene. Diseases associated with APOA4 include Carotenemia and Familial Hypercholesterolemia. Among its related pathways are Statin Pathway and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and copper ion binding. An important paralog of this gene is APOA5.
UniProtKB/Swiss-Prot Summary for APOA4 Gene
-
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Additional gene information for APOA4 Gene
- HGNC (602)
- NCBI Entrez Gene (337)
- Ensembl (ENSG00000110244)
- OMIM® (107690)
- UniProtKB/Swiss-Prot (P06727)
- Open Targets Platform(ENSG00000110244)
- Alliance of Genome Resources
- Search for APOA4 at DataMed
- Search for APOA4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APOA4 Gene
Genomics for APOA4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for APOA4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around APOA4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for APOA4
- Top Transcription factor binding sites by QIAGEN in the APOA4 gene promoter:
-
- COUP
- COUP-TF
- COUP-TF1
- HNF-4alpha1
- HNF-4alpha2
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for APOA4 Gene
Latest Assembly
- chr11:116,820,700-116,823,304
- (GRCh38/hg38)
- Size:
- 2,605 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:116,691,416-116,694,020
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 2,605 bases
- Orientation:
- Minus strand
Genomic View for APOA4 Gene
Genes around APOA4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.3 by HGNC
- 11q23.3 by Entrez Gene
- 11q23.3 by Ensembl
APOA4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOA4 Gene
Proteins for APOA4 Gene
-
Protein details for APOA4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P06727-APOA4_HUMAN
- Recommended name:
- Apolipoprotein A-IV
- Protein Accession:
- P06727
- A8MSL6
- Q14CW8
- Q6Q787
Protein attributes for APOA4 Gene
- Size:
- 396 amino acids
- Molecular mass:
- 45372 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for APOA4 Gene
Post-translational modifications for APOA4 Gene
- Phosphorylation sites are present in the extracellular medium.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for APOA4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences APOA4 Antibody and APOA4 Monoclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for APOA4
- Novus Biologicals Antibodies for APOA4
-
Abcam antibodies for APOA4
- Invitrogen Antibodies for APOA4 (AFLGC-APOA4)
- antibodies-online: Show 225 available APOA4 Antibodies ranked by validation data
- Compare Top APOA4 Antibodies
-
Recommended
- 111 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for APOA4
- Sino Biological Antibodies for APOA4
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for APOA4
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- Sino Biological Cell Lysates for APOA4
-
ProSci Proteins for APOA4
-
Abcam proteins for APOA4
Assay products for research
- Novus Biologicals ELISA Kits for APOA4
- antibodies-online: Show 72 available APOA4 Elisa Kits ranked by validation data
- Compare Top APOA4 Elisa Kits
-
Quality Products:
- ABIN6574298
- ABIN1113520
- ABIN414838
- ABIN5523869
- ABIN828051
- ABIN5669236
- ABIN1081229
- ABIN1028140
- ABIN5594148
- ABIN511211
- ABIN6574299
- ABIN425218
- ABIN810809
- ABIN1568444
- ABIN4947363
- ABIN627497
- ABIN5651901
- ABIN5651900
- ABIN2541616
- ABIN4967240
- ABIN432440
- ABIN810810
- ABIN1568446
- ABIN4993321
- ABIN626666
- ABIN5651903
- ABIN2541618
- ABIN4967239
- ABIN6225429
- ABIN1122201
- ABIN1568445
- ABIN431294
- ABIN5523870
- ABIN778033
- ABIN1559264
- ABIN5651902
- ABIN2541617
- ABIN6225426
- ABIN2945334
- ABIN5072573
-
Abcam assays for APOA4
No data available for DME Specific Peptides for APOA4 Gene
Domains & Families for APOA4 Gene
Gene Families for APOA4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Candidate cardiovascular disease genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for APOA4 Gene
- InterPro:
- Blocks:
-
- Apolipoprotein A1/A4/E
Suggested Antigen Peptide Sequences for APOA4 Gene
- GenScript: Design optimal peptide antigens:
-
- Apolipoprotein A4 (APOA4_HUMAN)
- APOA4 protein (Q13784_HUMAN)
- Apolipoprotein A-IV (Q15969_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P06727UniProtKB/Swiss-Prot:
APOA4_HUMAN :- Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
- Belongs to the apolipoprotein A1/A4/E family.
- Domain:
-
- Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
- Family:
-
- Belongs to the apolipoprotein A1/A4/E family.
Function for APOA4 Gene
Molecular function for APOA4 Gene
- UniProtKB/Swiss-Prot Function:
- May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
- GENATLAS Biochemistry:
- apolipoprotein A-IV,major component of HDL and chylomicrons,involved in the catabolism of chylomicrons and VLDL
Phenotypes From GWAS Catalog for APOA4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005319 | lipid transporter activity | TAS | 3080432 |
| GO:0005507 | copper ion binding | IDA | 16945374 |
| GO:0005515 | protein binding | IPI | 24311788 |
| GO:0005543 | phospholipid binding | IBA | 21873635 |
| GO:0008289 | lipid binding | IMP | 16159879 |
Phenotypes for APOA4 Gene
- MGI mutant phenotypes for APOA4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for APOA4:
Animal Models for APOA4 Gene
- MGI Knock Outs for APOA4:
-
- Apoa4 Apoa4<tm1Bres>
Animal Models for research
-
Taconic Biosciences Mouse Models for APOA4
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for APOA4 - Starting at $85 >
- * APOA4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for APOA4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOA4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOA4
- Browse OriGene Inhibitory RNA Products For APOA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOA4
Clone products for research
- Applied Biological Materials (abm): Clones for APOA4 - Starting at $45 >
- * APOA4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for APOA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOA4
Cell Lines for research
-
Horizon Cell Lines for APOA4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for APOA4 Gene
Localization for APOA4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOA4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| endosome | 4 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 1935934 |
| GO:0005769 | early endosome | TAS | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for APOA4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Statin Pathway |
.71
|
|
| 2 | Lipoprotein metabolism | ||
| 3 | Metabolism of fat-soluble vitamins | ||
| 4 | Metabolism |
.40
|
|
| 5 | Ca, cAMP and Lipid Signaling | ||
Pathways by source for APOA4 Gene
1 BioSystems pathway for APOA4 Gene
12 Reactome pathways for APOA4 Gene
1 PharmGKB pathway for APOA4 Gene
4 KEGG pathways for APOA4 Gene
1 GeneGo (Thomson Reuters) pathway for APOA4 Gene
- Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
1 Cell Signaling Technology pathway for APOA4 Gene
Interacting Proteins for APOA4 Gene
Selected Interacting proteins:
P06727-APOA4_HUMAN
ENSP00000350425
for APOA4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for APOA4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001523 | retinoid metabolic process | TAS | -- |
| GO:0002227 | innate immune response in mucosa | IDA | 15254593 |
| GO:0006695 | cholesterol biosynthetic process | IBA | 21873635 |
| GO:0006869 | lipid transport | IDA | 1935934 |
| GO:0006982 | response to lipid hydroperoxide | IDA | 16945374 |
No data available for SIGNOR curated interactions for APOA4 Gene
Drugs & Compounds for APOA4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Torvoside G |
|
184777-22-8, 30719-27-8 | ||||
| Triglycerides Group A |
|
555-45-3, 2190-24-1, 18641-57-1, 56933-26-7 | ||||
| Triglycerides Group C |
|
620-64-4 |
Transcripts for APOA4 Gene
mRNA/cDNA for APOA4 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000357780 1471 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for APOA4 - Starting at $85 >
- * APOA4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for APOA4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOA4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOA4
- Browse OriGene Inhibitory RNA Products For APOA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOA4
Clone products for research
- Applied Biological Materials (abm): Clones for APOA4 - Starting at $45 >
- * APOA4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for APOA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOA4
Relevant External Links for APOA4 Gene
- GeneLoc Exon Structure for
- APOA4
Expression for APOA4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for APOA4 Gene
This gene is overexpressed in Small Intestine - Terminal Ileum (x37.5) and Liver (x15.0).
This gene is overexpressed in Serum (28.2), Synovial fluid (13.5), and Plasma (12.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOA4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APOA4
SOURCE GeneReport for Unigene cluster for APOA4 Gene:
Hs.1247mRNA Expression by UniProt/SwissProt for APOA4 Gene:
P06727-APOA4_HUMAN
Tissue specificity:
Synthesized primarily in the intestine and secreted in plasma.
Evidence on tissue expression from TISSUES for APOA4 Gene
- Intestine(4.6)
- Nervous system(4.4)
- Liver(3.5)
- Heart(3.4)
- Blood(2.6)
- Kidney(2.5)
- Pancreas(2.2)
Primer products for research
-
OriGene qPCR primer pairs for APOA4
-
OriGene qPCR primer pairs and template standards for APOA4
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APOA4 Gene
Orthologs for APOA4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | APOA4 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | APOA4 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | APOA4 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Apoa4 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Apoa4 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | APOA4 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | APOA4 29 |
|
||
| APOAIV 30 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | APOA4 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | apoa4 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-7f3.15 29 |
|
||
| apoa4 30 |
|
OneToMany | |||
| APOA4 (4 of 4) 30 |
|
OneToMany | |||
| APOA4 (1 of 4) 30 |
|
OneToMany | |||
| APOA4 (3 of 4) 30 |
|
OneToMany |
- Species where no ortholog for APOA4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for APOA4 Gene
- ENSEMBL:
- Gene Tree for APOA4 (if available)
- TreeFam:
- Gene Tree for APOA4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for APOA4: view image
- Alliance of Genome Resources:
- Additional Orthologs for APOA4
Paralogs for APOA4 Gene
Variants for APOA4 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for APOA4 Gene
- APOA4_HUMAN-P06727
- Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APOA4 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs121909576 | Other: APOLIPOPROTEIN A-IV RARE VARIANT, APOA4*3 | 116,821,310(-) |
C/Tp.Glu250Lys NM_000482.3(APOA4):c.748G>A (p.Glu250Lys) |
MISSENSE | |
| rs146353487 | Benign: not provided | 116,821,001(-) |
A/C NM_000482.4(APOA4):c.1057T>G (p.Ser353Ala) |
MISSENSE | |
| rs5105 | Benign: not provided | 116,821,278(-) |
G/A NM_000482.4(APOA4):c.780C>T (p.Ala260=) |
SYNONYMOUS | |
| rs5106 | Benign: not provided | 116,821,212(-) |
G/A NM_000482.4(APOA4):c.846C>T (p.Thr282=) |
SYNONYMOUS | |
| rs5109 | Benign: not provided | 116,821,050(-) |
C/A NM_000482.4(APOA4):c.1008G>T (p.Val336=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.39;
54.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for APOA4 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Structural Variations from Database of Genomic Variants (DGV) for APOA4 Gene
Disorders for APOA4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| carotenemia |
|
|
| familial hypercholesterolemia |
|
|
| amyloidosis, familial visceral |
|
|
| hyperlipidemia, familial combined, 3 |
|
|
| hypobetalipoproteinemia, familial, 1 |
|
|
Search APOA4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for APOA4
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for APOA4 Gene
Publications for APOA4 Gene
- Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population. (PMID: 1349197) von Eckardstein A … Assmann G (American journal of human genetics 1992) 3 4 22 40
- Distribution and effect of apo A-IV genotype on plasma lipid and apolipoprotein levels in a Chinese population. (PMID: 18664021) Bai H … Liu BW (Acta cardiologica 2008) 3 22 40
- Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men. (PMID: 17130180) Humphries SE … Miller GJ (Clinical chemistry 2007) 3 22 40
- Genetic and environmental factors affecting the response to statin therapy in patients with molecularly defined familial hypercholesterolaemia. (PMID: 15864114) Miltiadous G … Elisaf M (Pharmacogenetics and genomics 2005) 3 22 40
- Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia. (PMID: 16030523) van Aalst-Cohen ES … Kastelein JJ (European journal of human genetics : EJHG 2005) 3 22 40
ExternalLinks
Products for APOA4 Gene
- View all 3 R&D Systems APOA4 (Apolipoprotein A-IV/ApoA4) Products
- View all R&D Systems APOA4 (Apolipoprotein A-IV/ApoA4) Proteins and Enzymes
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for APOA4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for APOA4 (AFLGC-APOA4)
- VectorBuilder Custom and pre-made DNA vectors for APOA4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for APOA4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for APOA4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for APOA4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for APOA4
- antibodies-online: Show 225 available APOA4 Antibodies ranked by validation data
- Compare Top APOA4 Antibodies
- Recommended
- 111 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- antibodies-online: Show 72 available APOA4 Elisa Kits ranked by validation data
- Compare Top APOA4 Elisa Kits
- Quality Products:
- ABIN6574298
- ABIN1113520
- ABIN414838
- ABIN5523869
- ABIN828051
- ABIN5669236
- ABIN1081229
- ABIN1028140
- ABIN5594148
- ABIN511211
- ABIN6574299
- ABIN425218
- ABIN810809
- ABIN1568444
- ABIN4947363
- ABIN627497
- ABIN5651901
- ABIN5651900
- ABIN2541616
- ABIN4967240
- ABIN432440
- ABIN810810
- ABIN1568446
- ABIN4993321
- ABIN626666
- ABIN5651903
- ABIN2541618
- ABIN4967239
- ABIN6225429
- ABIN1122201
- ABIN1568445
- ABIN431294
- ABIN5523870
- ABIN778033
- ABIN1559264
- ABIN5651902
- ABIN2541617
- ABIN6225426
- ABIN2945334
- ABIN5072573
- antibodies-online: Show 29 available APOA4 Proteins ranked by validation data
- Compare Top APOA4 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for APOA4
- Search Santa Cruz Biotechnology (SCBT) for APOA4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for APOA4
- Custom Antibody ServicesProSci Antibodies for APOA4
- ProSci Proteins for APOA4
- Horizon Cell Lines for APOA4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APOA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APOA4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for APOA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOA4
Sources for APOA4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources