External Ids for APOA4 Gene
Previous GeneCards Identifiers for APOA4 Gene
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOA4 Gene
APOA4 (Apolipoprotein A4) is a Protein Coding gene. Diseases associated with APOA4 include Carotenemia and Familial Hypercholesterolemia. Among its related pathways are Lipoprotein metabolism and Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and copper ion binding. An important paralog of this gene is APOA5.
UniProtKB/Swiss-Prot Summary for APOA4 Gene
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.