Aliases for APMAP Gene

Aliases for APMAP Gene

  • Adipocyte Plasma Membrane Associated Protein 2 3 5
  • Adipocyte Plasma Membrane-Associated Protein 3 4
  • Protein BSCv 3 4
  • C20orf3 3 4
  • BSCv 2 3
  • Chromosome 20 Open Reading Frame 3 2
  • APMAP 5

External Ids for APMAP Gene

Previous HGNC Symbols for APMAP Gene

  • C20orf3

Previous GeneCards Identifiers for APMAP Gene

  • GC20M024945

Summaries for APMAP Gene

GeneCards Summary for APMAP Gene

APMAP (Adipocyte Plasma Membrane Associated Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include arylesterase activity and strictosidine synthase activity.

UniProtKB/Swiss-Prot Summary for APMAP Gene

  • Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.

Gene Wiki entry for APMAP Gene

Additional gene information for APMAP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APMAP Gene

Genomics for APMAP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for APMAP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J024989 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 608.4 +1.3 1281 5.2 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 SOX13 NFKBIZ APMAP ENSG00000286444 CST7 ACSS1 VN1R108P PYGB RF00026-637 RNU6-1257P
GH20J024994 Enhancer 1 ENCODE dbSUPER 608.2 -2.0 -1950 0.8 GATAD2A CTCF PRDM10 NFKBIZ ZNF7 TARDBP ZNF143 ZIC2 PKNOX1 REST APMAP CST7 ZNF337 NINL piR-61101-409 ACSS1
GH20J024948 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.2 +40.2 40151 8.4 HNRNPL ZIC2 SP1 PKNOX1 MNT HES1 NFIC CEBPG POLR2A SPI1 CST7 MN297799 APMAP ACSS1 VN1R108P PYGB
GH20J025016 Enhancer 1.2 Ensembl ENCODE dbSUPER 19.3 -25.1 -25145 3.4 GATAD2A TFE3 TARDBP FOXA1 ZIC2 RXRB IRF2 PBX2 CEBPA SCRT2 APMAP ACSS1 CST7 piR-61101-409 piR-59264
GH20J024957 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +31.1 31082 9.2 MNT CTCF RBM22 ZFHX2 POLR2A SPI1 FOXA1 GLIS1 TBX21 FOS piR-51393 CST7 APMAP ACSS1 VN1R108P MN297799
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APMAP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for APMAP

Genomic Locations for APMAP Gene

Genomic Locations for APMAP Gene
30,006 bases
Minus strand
30,055 bases
Minus strand

Genomic View for APMAP Gene

Genes around APMAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APMAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APMAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APMAP Gene

Proteins for APMAP Gene

  • Protein details for APMAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adipocyte plasma membrane-associated protein
    Protein Accession:
    Secondary Accessions:
    • A8K514
    • B4DXG1
    • Q6UVZ8
    • Q9GZS8
    • Q9NUB2

    Protein attributes for APMAP Gene

    416 amino acids
    Molecular mass:
    46480 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89435.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB11885.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15253.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15578.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for APMAP Gene


neXtProt entry for APMAP Gene

Post-translational modifications for APMAP Gene

  • Glycosylation at Asn160 and Asn196
  • Ubiquitination at Lys123, Lys179, and Lys220
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • APMAP_HUMAN (797)

Other Protein References for APMAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APMAP Gene

Domains & Families for APMAP Gene

Gene Families for APMAP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for APMAP Gene

  • Strictosidine synthase

Suggested Antigen Peptide Sequences for APMAP Gene

GenScript: Design optimal peptide antigens:
  • Chromosome 20 open reading frame 3 (A2A2F9_HUMAN)
  • Protein BSCv (APMAP_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the strictosidine synthase family.
  • Belongs to the strictosidine synthase family.
genes like me logo Genes that share domains with APMAP: view

Function for APMAP Gene

Molecular function for APMAP Gene

UniProtKB/Swiss-Prot Function:
Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.

Phenotypes From GWAS Catalog for APMAP Gene

Gene Ontology (GO) - Molecular Function for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004064 arylesterase activity IDA 18513186
GO:0016844 strictosidine synthase activity IEA --
genes like me logo Genes that share ontologies with APMAP: view
genes like me logo Genes that share phenotypes with APMAP: view

Animal Models for APMAP Gene

MGI Knock Outs for APMAP:
  • Apmap Apmap<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for APMAP Gene

miRTarBase miRNAs that target APMAP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APMAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APMAP Gene

Localization for APMAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for APMAP Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APMAP gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
golgi apparatus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0009986 cell surface IDA 18513186
GO:0016020 membrane IEA,IDA 18513186
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APMAP: view

Pathways & Interactions for APMAP Gene

PathCards logo

SuperPathways for APMAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with APMAP: view

No data available for Pathways by source and SIGNOR curated interactions for APMAP Gene

Drugs & Compounds for APMAP Gene

No Compound Related Data Available

Transcripts for APMAP Gene

mRNA/cDNA for APMAP Gene

9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APMAP

Alternative Splicing Database (ASD) splice patterns (SP) for APMAP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: -

Relevant External Links for APMAP Gene

GeneLoc Exon Structure for

Expression for APMAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for APMAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APMAP Gene

This gene is overexpressed in Whole Blood (x7.6) and Liver (x4.9).

Protein differential expression in normal tissues from HIPED for APMAP Gene

This gene is overexpressed in Nasal epithelium (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APMAP Gene

Protein tissue co-expression partners for APMAP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APMAP

SOURCE GeneReport for Unigene cluster for APMAP Gene:


mRNA Expression by UniProt/SwissProt for APMAP Gene:

Tissue specificity: Liver, glomerular and tubular structures of the kidney, endothelial cells, arterial wall and pancreatic islets of Langerhans (at protein level). Found ubiquitously in adult as well as in embryonic tissues. In adult tissue, the highest expression is found in the liver, placenta and heart. Found on the cell surface of monocytes. In embryonic tissue, the highest expression levels is found in the liver and the kidney.

Evidence on tissue expression from TISSUES for APMAP Gene

  • Nervous system(4.6)
  • Liver(4.5)
  • Muscle(4.4)
  • Bone marrow(4.4)
  • Skin(3.5)
  • Lung(3.4)
  • Blood(3.3)
  • Thyroid gland(3.3)
  • Pancreas(3.2)
  • Eye(2.4)
  • Intestine(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with APMAP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APMAP Gene

Orthologs for APMAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for APMAP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APMAP 30
  • 99.52 (n)
C20H20ORF3 31
  • 99 (a)
(Canis familiaris)
Mammalia APMAP 30 31
  • 89.08 (n)
(Mus musculus)
Mammalia Apmap 30 17 31
  • 86.59 (n)
(Rattus norvegicus)
Mammalia Apmap 30
  • 86.08 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 85 (a)
-- 31
  • 74 (a)
-- 31
  • 65 (a)
(Bos Taurus)
Mammalia APMAP 30 31
  • 84.39 (n)
(Monodelphis domestica)
Mammalia APMAP 31
  • 82 (a)
(Gallus gallus)
Aves APMAP 31
  • 76 (a)
C3H20ORF3 30
  • 71.81 (n)
(Anolis carolinensis)
Reptilia APMAP 31
  • 74 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485177 30
  • 67.47 (n)
Str.3092 30
(Danio rerio)
Actinopterygii apmap 30 31
  • 64.1 (n)
Dr.99 30
Fruit Fly
(Drosophila melanogaster)
Insecta Hmu 30 31
  • 46.04 (n)
Ssl2 31
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004065 30
  • 45.7 (n)
(Caenorhabditis elegans)
Secernentea CELE_C08E8.2 30
  • 47.18 (n)
C08E8.2 31
  • 35 (a)
F57C2.5 31
  • 34 (a)
T12G3.4 31
  • 29 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G57030 30
  • 47.54 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6521 31
  • 29 (a)
-- 31
  • 29 (a)
CSA.3211 31
  • 28 (a)
-- 31
  • 27 (a)
Species where no ortholog for APMAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for APMAP Gene

Gene Tree for APMAP (if available)
Gene Tree for APMAP (if available)
Evolutionary constrained regions (ECRs) for APMAP: view image

Paralogs for APMAP Gene

No data available for Paralogs for APMAP Gene

Variants for APMAP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APMAP Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs12242 - p.Ile65Val
rs28364786 - p.Arg374Trp
rs35097515 - p.Arg282Gln

Additional dbSNP identifiers (rs#s) for APMAP Gene

Structural Variations from Database of Genomic Variants (DGV) for APMAP Gene

Variant ID Type Subtype PubMed ID
esv2133962 CNV deletion 18987734
esv2629879 CNV deletion 19546169
esv2722321 CNV deletion 23290073
esv2722322 CNV deletion 23290073
esv2722323 CNV deletion 23290073
esv2762068 CNV loss 21179565
esv3645552 CNV gain 21293372
esv3645567 CNV gain 21293372
esv3645573 CNV gain 21293372
esv989269 CNV deletion 20482838
nsv1056345 CNV gain 25217958
nsv1145859 CNV deletion 26484159
nsv510486 OTHER sequence alteration 20534489
nsv522873 CNV gain 19592680
nsv585745 CNV loss 21841781
nsv953007 CNV deletion 24416366
nsv953008 CNV duplication 24416366

Variation tolerance for APMAP Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APMAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APMAP Gene

Disorders for APMAP Gene

No disorders were found for APMAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APMAP Gene

Publications for APMAP Gene

  1. Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3). (PMID: 10945474) Morita M … Nishimura S (Genomics 2000) 2 3 4 23
  2. Identification of a novel integral plasma membrane protein induced during adipocyte differentiation. (PMID: 11583587) Albrektsen T … Fleckner J (The Biochemical journal 2001) 2 3 23
  3. Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARγ. (PMID: 20552250) Bogner-Strauss JG … Trajanoski Z (Cellular and molecular life sciences : CMLS 2010) 2 3
  4. Localization and characterization of the novel protein encoded by C20orf3. (PMID: 18513186) Ilhan A … Wagner L (The Biochemical journal 2008) 3 4
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4

Products for APMAP Gene

Sources for APMAP Gene