Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at th... See more...
Aliases for APLP2 Gene
Aliases for APLP2 Gene
External Ids for APLP2 Gene
- HGNC: 598
- NCBI Entrez Gene: 334
- Ensembl: ENSG00000084234
- OMIM®: 104776
- UniProtKB/Swiss-Prot: Q06481
Previous HGNC Symbols for APLP2 Gene
- APPL2
Previous GeneCards Identifiers for APLP2 Gene
- GC11P131940
- GC11P131452
- GC11P129973
- GC11P129477
- GC11P129445
- GC11P129939
- GC11P125891
Summaries for APLP2 Gene
-
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
GeneCards Summary for APLP2 Gene
APLP2 (Amyloid Beta Precursor Like Protein 2) is a Protein Coding gene. Diseases associated with APLP2 include Exudative Vitreoretinopathy 5 and Alzheimer Disease. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include identical protein binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is APP.
UniProtKB/Swiss-Prot Summary for APLP2 Gene
-
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
Additional gene information for APLP2 Gene
- HGNC (598)
- NCBI Entrez Gene (334)
- Ensembl (ENSG00000084234)
- OMIM® (104776)
- UniProtKB/Swiss-Prot (Q06481)
- Open Targets Platform(ENSG00000084234)
- Search for APLP2 at DataMed
- Search for APLP2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APLP2 Gene
Genomics for APLP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for APLP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around APLP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for APLP2
- Top Transcription factor binding sites by QIAGEN in the APLP2 gene promoter:
-
- CBF-A
- CBF-B
- CP1A
- FOXC1
- NF-Y
- NF-YA
- NF-YB
- p53
- Pax-4a
- TBP
Genomic Locations for APLP2 Gene
Latest Assembly
- chr11:130,068,147-130,144,811
- (GRCh38/hg38)
- Size:
- 76,665 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:129,939,789-130,014,700
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 74,912 bases
- Orientation:
- Plus strand
- chr11:129,939,732-130,014,699
- (GRCh37/hg19 by Ensembl)
- Size:
- 74,968 bases
- Orientation:
- Plus strand
Genomic View for APLP2 Gene
Genes around APLP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.3 by HGNC
- 11q24.3 by Entrez Gene
- 11q24.3 by Ensembl
APLP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APLP2 Gene
Proteins for APLP2 Gene
-
Protein details for APLP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q06481-APLP2_HUMAN
- Recommended name:
- Amyloid-like protein 2
- Protein Accession:
- Q06481
- B3KXX9
- H7BXI4
- Q13861
- Q14594
- Q14662
- Q71U10
- Q7M4L3
- Q9BT36
Protein attributes for APLP2 Gene
- Size:
- 763 amino acids
- Molecular mass:
- 86956 Da
- Quaternary structure:
-
- Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity).
- SequenceCaution:
-
- Sequence=BAG54641.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for APLP2 Gene
Post-translational modifications for APLP2 Gene
Other Protein References for APLP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001135748.1
- NP_001135749.1
- NP_001135750.1
- NP_001230228.1
- NP_001315611.1
- NP_001315613.1
- NP_001315614.1
- NP_001315615.1
- NP_001369455.1
- NP_001369456.1
- NP_001369457.1
- NP_001369458.1
- NP_001369459.1
- NP_001369460.1
- NP_001369461.1
- NP_001369462.1
- NP_001369463.1
- NP_001369464.1
- NP_001369465.1
- NP_001369466.1
- NP_001369467.1
- NP_001369468.1
- NP_001369469.1
- NP_001369470.1
- NP_001369471.1
- NP_001369472.1
- NP_001369473.1
- NP_001369474.1
- NP_001369475.1
- NP_001633.1
Antibodies for research
- LifeSpan BioSciences APLP2 Antibody
- G Biosciences Immunotag™ APLP2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for APLP2
- Novus Biologicals Antibodies for APLP2
-
Abcam antibodies for APLP2
- Invitrogen Antibodies for APLP2 (AFLGC-APLP2)
- antibodies-online: Show 48 available APLP2 Antibodies ranked by validation data
- Compare Top APLP2 Antibodies
-
Recommended
- 78 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 41 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 29 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 5 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for APLP2
- Sino Biological Antibodies for APLP2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for APLP2
- Origene Custom Protein Services for APLP2
-
Abcam proteins for APLP2
Assay products for research
- antibodies-online: Show 9 available APLP2 Elisa Kits ranked by validation data
- Compare Top APLP2 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for APLP2
No data available for DME Specific Peptides for APLP2 Gene
Domains & Families for APLP2 Gene
Gene Families for APLP2 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for APLP2 Gene
- InterPro:
- Blocks:
-
- Amyloidogenic glycoprotein (Amyloid A4)
- Pancreatic trypsin inhibitor (Kunitz)
- ProtoNet:
Suggested Antigen Peptide Sequences for APLP2 Gene
- GenScript: Design optimal peptide antigens:
-
- CDEI box-binding protein (APLP2_HUMAN)
- cDNA FLJ55088, highly similar to Amyloid-like protein 2 (Amyloidprotein homolog) (APPH) (CDEI box-binding protein)(CDEBP) (B4DKY3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q06481- Family:
-
- Belongs to the APP family.
Function for APLP2 Gene
Molecular function for APLP2 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
- GENATLAS Biochemistry:
- amyloid beta (A4) precursor protein-like 2
Phenotypes From GWAS Catalog for APLP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS | 7702756 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 8855266 |
| GO:0008201 | heparin binding | IEA | -- |
| GO:0030414 | peptidase inhibitor activity | IEA | -- |
Phenotypes for APLP2 Gene
- MGI mutant phenotypes for APLP2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for APLP2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased POU5F1-GFP protein expression
- Decreased IL-8 secretion
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Increased TP53 protein expression ratio (wild-type / TP53 knockout cells)
Animal Models for APLP2 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for APLP2 - Starting at $85 >
- * APLP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for APLP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APLP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for APLP2
miRNA for APLP2 Gene
- miRTarBase miRNAs that target APLP2
-
- mmu-miR-301b-3p (MIRT007814)
- mmu-miR-7b-5p (MIRT009178)
- mmu-miR-223-3p (MIRT009638)
- mmu-miR-17-5p (MIRT009916)
- mmu-miR-15a-5p (MIRT011609)
- mmu-miR-181a-5p (MIRT014095)
- hsa-miR-7-5p (MIRT025806)
- hsa-miR-346 (MIRT042713)
- hsa-miR-106b-5p (MIRT044252)
- hsa-miR-93-5p (MIRT048819)
- hsa-miR-1260b (MIRT052735)
- hsa-miR-3671 (MIRT495979)
- hsa-miR-548v (MIRT495980)
- hsa-miR-3185 (MIRT495981)
- hsa-miR-513b-3p (MIRT495982)
- mmu-miR-125a-3p (MIRT584871)
- hsa-miR-30e-5p (MIRT705589)
- hsa-miR-30d-5p (MIRT705590)
- hsa-miR-30c-5p (MIRT705591)
- hsa-miR-30b-5p (MIRT705592)
- hsa-miR-30a-5p (MIRT705593)
- hsa-miR-1324 (MIRT705594)
- hsa-miR-1178-5p (MIRT735861)
- hsa-miR-1270 (MIRT736731)
- hsa-miR-148a-3p (MIRT737664)
- hsa-miR-148b-3p (MIRT737677)
- hsa-miR-152-3p (MIRT737866)
- hsa-miR-198 (MIRT738714)
- hsa-miR-33b-3p (MIRT741372)
- hsa-miR-3973 (MIRT743195)
- hsa-miR-4434 (MIRT744392)
- hsa-miR-4516 (MIRT745745)
- hsa-miR-4531 (MIRT745979)
- hsa-miR-455-5p (MIRT746253)
- hsa-miR-4697-3p (MIRT747216)
- hsa-miR-515-3p (MIRT749790)
- hsa-miR-519e-3p (MIRT750172)
- hsa-miR-520a-5p (MIRT750186)
- hsa-miR-525-5p (MIRT750293)
- hsa-miR-5703 (MIRT751348)
- hsa-miR-6089 (MIRT751948)
- hsa-miR-620 (MIRT752550)
- hsa-miR-6507-3p (MIRT752958)
- hsa-miR-6866-5p (MIRT757936)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APLP2
- Browse OriGene Inhibitory RNA Products For APLP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APLP2
Clone products for research
- Applied Biological Materials (abm): Clones for APLP2 - Starting at $45 >
- * APLP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210097
- MG210177
- MG226207
- MR210097
- MR210097L3
- MR210097L4
- MR210177
- MR210177L3
- MR210177L4
- MR226207
- MR226207L3
- MR226207L4
- RC222494
- RC222494L1
- RC222494L2
- RC222494L3
- RC222494L4
- RC226552
- RC226552L1
- RC226552L2
- RC226552L3
- RC226552L4
- RC226790
- RC226790L3
- RC226790L4
- RC227009
- RC227009L3
- RC227009L4
- RC234850
- RG222494
- RG226552
- RG226790
- RG227009
- RG234850
- RR217172
- RR217188
- MR210097L3V
- MR210097L4V
- MR210177L3V
- MR210177L4V
- MR226207L3V
- MR226207L4V
- RC222494L1V
- RC222494L2V
- RC222494L3V
- RC222494L4V
- RC226552L1V
- RC226552L2V
- RC226552L3V
- RC226552L4V
- RC226790L3V
- RC226790L4V
- RC227009L3V
- RC227009L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for APLP2
- Addgene plasmids for APLP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APLP2
Cell Lines for research
-
Horizon Cell Lines for APLP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APLP2 Gene
Localization for APLP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for APLP2 Gene
- Cell membrane. Single-pass type I membrane protein. Nucleus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| extracellular | 4 |
| endoplasmic reticulum | 4 |
| cytoskeleton | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 7702756 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
| GO:0016021 | integral component of membrane | NAS | 8485127 |
Pathways & Interactions for APLP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for APLP2 Gene
4 Reactome pathways for APLP2 Gene
Interacting Proteins for APLP2 Gene
Selected Interacting proteins:
Q06481-APLP2_HUMAN
ENSP00000263574
for APLP2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for APLP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | NAS | 8220435 |
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
| GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
Drugs & Compounds for APLP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zinc | Approved, Investigational | Pharma | Target, cofactor | 1687 | ||
| zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
| Zinc chloride | Approved, Investigational | Pharma | Target, ligand | 0 | ||
| Zinc sulfate, unspecified form | Approved, Experimental | Pharma | Target, ligand | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for APLP2 Gene
mRNA/cDNA for APLP2 Gene
- 30 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 26 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263574 3727 nts (view in UCSC)
- ENST00000278756 3687 nts (view in UCSC)
- ENST00000338167 3697 nts (view in UCSC)
- ENST00000345598 1862 nts (view in UCSC)
- ENST00000461918 553 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for APLP2 - Starting at $85 >
- * APLP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for APLP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APLP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for APLP2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APLP2
- Browse OriGene Inhibitory RNA Products For APLP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APLP2
Clone products for research
- Applied Biological Materials (abm): Clones for APLP2 - Starting at $45 >
- * APLP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210097
- MG210177
- MG226207
- MR210097
- MR210097L3
- MR210097L4
- MR210177
- MR210177L3
- MR210177L4
- MR226207
- MR226207L3
- MR226207L4
- RC222494
- RC222494L1
- RC222494L2
- RC222494L3
- RC222494L4
- RC226552
- RC226552L1
- RC226552L2
- RC226552L3
- RC226552L4
- RC226790
- RC226790L3
- RC226790L4
- RC227009
- RC227009L3
- RC227009L4
- RC234850
- RG222494
- RG226552
- RG226790
- RG227009
- RG234850
- RR217172
- RR217188
- MR210097L3V
- MR210097L4V
- MR210177L3V
- MR210177L4V
- MR226207L3V
- MR226207L4V
- RC222494L1V
- RC222494L2V
- RC222494L3V
- RC222494L4V
- RC226552L1V
- RC226552L2V
- RC226552L3V
- RC226552L4V
- RC226790L3V
- RC226790L4V
- RC227009L3V
- RC227009L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for APLP2
- Addgene plasmids for APLP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APLP2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for APLP2 Gene
- GeneLoc Exon Structure for
- APLP2
Expression for APLP2 Gene
This gene is overexpressed in Vitreous humor (20.9), Liver (9.4), Peripheral blood mononuclear cells (8.2), Cerebrospinal fluid (6.7), and Amniocyte (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APLP2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APLP2
SOURCE GeneReport for Unigene cluster for APLP2 Gene:
Hs.370247mRNA Expression by UniProt/SwissProt for APLP2 Gene:
Q06481-APLP2_HUMAN
Tissue specificity:
Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
Evidence on tissue expression from TISSUES for APLP2 Gene
- Nervous system(5)
- Kidney(5)
- Lung(4.9)
- Pancreas(4.9)
- Skin(4.8)
- Blood(4.7)
- Liver(4.7)
- Intestine(4.6)
- Eye(4.5)
- Heart(4.3)
- Stomach(4.2)
- Thyroid gland(3.5)
- Spleen(3.2)
- Muscle(2.9)
- Adrenal gland(2.6)
- Bone marrow(2.3)
- Gall bladder(2.2)
- Lymph node(2.1)
- Bone(2)
Primer products for research
-
OriGene qPCR primer pairs for APLP2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APLP2 Gene
Orthologs for APLP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | APLP2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | APLP2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Aplp2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Aplp2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | APLP2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | APLP2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | APLP2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | APLP2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | APLP2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.3393 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | aplp2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Appl 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | apl-1 31 32 |
|
OneToMany |
- Species where no ortholog for APLP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for APLP2 Gene
- ENSEMBL:
- Gene Tree for APLP2 (if available)
- TreeFam:
- Gene Tree for APLP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for APLP2: view image
Paralogs for APLP2 Gene
(8) SIMAP similar genes for APLP2 Gene using alignment to 9 proteins:
- APLP2_HUMAN
- E9PK76_HUMAN
- E9PPD0_HUMAN
- E9PQS3_HUMAN
- E9PSC7_HUMAN
- F5GZY0_HUMAN
- F5H845_HUMAN
- L8E7K0_HUMAN
- Q9UED0_HUMAN
Variants for APLP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APLP2 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2298587 | Benign: not provided | 130,122,522(+) |
A/C NM_001142276.2(APLP2):c.922+9A>C |
INTRON | |
| rs371218526 | Benign: not provided | 130,140,492(+) |
G/A NM_001142276.2(APLP2):c.1923+9G>A |
INTRON | |
| rs745958507 | Likely Benign: not provided | 130,143,361(+) |
C/T NM_001142276.2(APLP2):c.2169C>T (p.Leu723=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs3740881 | - |
p.Asp632Asn |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2198n54 | CNV | gain | 21841781 |
| dgv2199n54 | CNV | loss | 21841781 |
| dgv251n67 | CNV | gain | 20364138 |
| esv1620466 | CNV | deletion | 17803354 |
| esv27072 | CNV | loss | 19812545 |
| esv2759871 | CNV | loss | 17122850 |
| esv3548519 | CNV | deletion | 23714750 |
| esv3579969 | CNV | loss | 25503493 |
| nsv1051470 | CNV | gain | 25217958 |
| nsv549 | CNV | insertion | 18451855 |
| nsv556565 | CNV | loss | 21841781 |
| nsv556566 | CNV | loss | 21841781 |
| nsv832295 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.19;
80.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for APLP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- APLP2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APLP2 Gene
Disorders for APLP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| exudative vitreoretinopathy 5 |
|
|
| alzheimer disease |
|
|
| spinocerebellar ataxia 7 |
|
|
| refractive error |
|
|
| lissencephaly |
|
|
Search APLP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for APLP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for APLP2 Gene
Publications for APLP2 Gene
- Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization. (PMID: 10702673) Leach R … Krawetz SA (Cytogenetics and cell genetics 1999) 2 3 23
- A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein. (PMID: 7702756) von der Kammer H … Scheit KH (DNA and cell biology 1994) 3 4 23
- Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. (PMID: 8220435) Wasco W … Tanzi RE (Nature genetics 1993) 3 4 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. (PMID: 19126676) Kaden D … Multhaup G (Journal of cell science 2009) 3 23
ExternalLinks
Products for APLP2 Gene
- Custom Antibody ServicesOriGene Antibodies for APLP2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for APLP2
- Origene Custom Protein Services for APLP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APLP2
- Browse OriGene Inhibitory RNA Products For APLP2
- OriGene qPCR primer pairs for APLP2
- OriGene CRISPR knockouts for APLP2
- MG210097
- MG210177
- MG226207
- MR210097
- MR210097L3
- MR210097L4
- MR210177
- MR210177L3
- MR210177L4
- MR226207
- MR226207L3
- MR226207L4
- RC222494
- RC222494L1
- RC222494L2
- RC222494L3
- RC222494L4
- RC226552
- RC226552L1
- RC226552L2
- RC226552L3
- RC226552L4
- RC226790
- RC226790L3
- RC226790L4
- RC227009
- RC227009L3
- RC227009L4
- RC234850
- RG222494
- RG226552
- RG226790
- RG227009
- RG234850
- RR217172
- RR217188
- MR210097L3V
- MR210097L4V
- MR210177L3V
- MR210177L4V
- MR226207L3V
- MR226207L4V
- RC222494L1V
- RC222494L2V
- RC222494L3V
- RC222494L4V
- RC226552L1V
- RC226552L2V
- RC226552L3V
- RC226552L4V
- RC226790L3V
- RC226790L4V
- RC227009L3V
- RC227009L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For APLP2
- Sino Biological Human cDNA Clone for APLP2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for APLP2
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for APLP2
- Novus Biologicals proteins and lysates for APLP2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for APLP2
- Abcam proteins for APLP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for APLP2 (AFLGC-APLP2)
- VectorBuilder Custom and pre-made DNA vectors for APLP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for APLP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for APLP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for APLP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for APLP2
- Addgene plasmids for APLP2
- antibodies-online: Show 48 available APLP2 Antibodies ranked by validation data
- Compare Top APLP2 Antibodies
- Recommended
- 78 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 41 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 29 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 5 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Show 9 available APLP2 Elisa Kits ranked by validation data
- Compare Top APLP2 Elisa Kits
- Quality Products:
- antibodies-online: Show 11 available APLP2 Proteins ranked by validation data
- Compare Top APLP2 Proteins
- Horizon Cell Lines for APLP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for APLP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for APLP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for APLP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APLP2
- Boster Bio Antibodies for APLP2
- Boster Bio ELISA Kits for APLP2
Sources for APLP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB