Aliases for APLP1 Gene
External Ids for APLP1 Gene
Previous GeneCards Identifiers for APLP1 Gene
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for APLP1 Gene
APLP1 (Amyloid Beta Precursor Like Protein 1) is a Protein Coding gene. Diseases associated with APLP1 include Subendocardial Myocardial Infarction and Alzheimer Disease. Gene Ontology (GO) annotations related to this gene include identical protein binding and alpha-2A adrenergic receptor binding. An important paralog of this gene is APLP2.
UniProtKB/Swiss-Prot Summary for APLP1 Gene
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.