Aliases for APLNR Gene
External Ids for APLNR Gene
Previous HGNC Symbols for APLNR Gene
Previous GeneCards Identifiers for APLNR Gene
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
GeneCards Summary for APLNR Gene
APLNR (Apelin Receptor) is a Protein Coding gene. Diseases associated with APLNR include Pulmonary Venoocclusive Disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is AGTR1.
UniProtKB/Swiss-Prot for APLNR Gene
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure by acting as a receptor for APLN hormone (PubMed:25639753, PubMed:28137936).
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199).
Apelin-36, apelin-13 and [Pyr1]-apelin-13 are the predominant endogenous ligands for the apelin receptor (APJ) receptor. The APJ receptor and apelin peptides act as mediators of cardiovascular function, fluid homeostasis and adipocyte endocrine secretion.