Aliases for APIP Gene
External Ids for APIP Gene
Previous GeneCards Identifiers for APIP Gene
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]
GeneCards Summary for APIP Gene
APIP (APAF1 Interacting Protein) is a Protein Coding gene. Diseases associated with APIP include Pyruvate Dehydrogenase E3-Binding Protein Deficiency. Among its related pathways are S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation and Metabolism. Gene Ontology (GO) annotations related to this gene include identical protein binding and methylthioribulose 1-phosphate dehydratase activity.
UniProtKB/Swiss-Prot Summary for APIP Gene
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.