Aliases for APIP Gene
External Ids for APIP Gene
Previous GeneCards Identifiers for APIP Gene
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]
GeneCards Summary for APIP Gene
APIP (APAF1 Interacting Protein) is a Protein Coding gene. Diseases associated with APIP include Endocervicitis and Alveolar Periostitis. Among its related pathways are Sulfur amino acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include identical protein binding and methylthioribulose 1-phosphate dehydratase activity.
UniProtKB/Swiss-Prot Summary for APIP Gene
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.