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This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
API5 (Apoptosis Inhibitor 5) is a Protein Coding gene. Diseases associated with API5 include Desmoid Disease, Hereditary and Asbestos-Related Lung Carcinoma. Gene Ontology (GO) annotations related to this gene include fibroblast growth factor binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 19387494 |
GO:0017134 | fibroblast growth factor binding | IPI | 11075807 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,IDA | 11075807 |
GO:0005681 | spliceosomal complex | ISS | 11555636 |
GO:0005737 | cytoplasm | NAS | 11075807 |
GO:0016020 | membrane | HDA | 19946888 |
GO:0016607 | nuclear speck | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | IEA | -- |
GO:0043066 | negative regulation of apoptotic process | TAS,NAS | 10780674 |
GO:2000270 | negative regulation of fibroblast apoptotic process | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | API5 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | API5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | API5 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | API5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | API5 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Api5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Api5 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | API5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | API5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | api5 30 |
|
||
Str.5903 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | srnyz021-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | api5 30 31 |
|
OneToOne | |
srnyz021 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6581 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009645 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Aac11 30 31 32 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G29030 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0313400 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2862934 | - | p.Gly493Ser | |||
rs5743240 | - | p.Met300Val | |||
VAR_021519 | - | p.Pro276Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3306211 | CNV | mobile element insertion | 20981092 |
esv3355802 | CNV | insertion | 20981092 |
nsv1145518 | CNV | deletion | 24896259 |
nsv554119 | CNV | gain | 21841781 |
nsv972004 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
desmoid disease, hereditary |
|
|
asbestos-related lung carcinoma |
|
|
lung cancer |
|
|