Aliases for APELA Gene
External Ids for APELA Gene
Previous GeneCards Identifiers for APELA Gene
This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/AKT pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. [provided by RefSeq, Jul 2016]
GeneCards Summary for APELA Gene
APELA (Apelin Receptor Early Endogenous Ligand) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hormone activity and apelin receptor binding.
UniProtKB/Swiss-Prot for APELA Gene
Hormone required for endoderm differentiation and heart morphogenesis during early development and for the adult cardiovascular system development by acting as a ligand for the apelin receptor (APLNR) (PubMed:25639753, PubMed:28137936). Drives internalization of the apelin receptor (PubMed:25639753, PubMed:28137936). Acts as a motogen by promoting endoderm and mesendoderm cell migration during gastrulation by binding and activating the apelin receptor (By similarity).