Aliases for APCDD1L Gene

Aliases for APCDD1L Gene

  • APC Down-Regulated 1 Like 2 3 5
  • Protein APCDD1-Like 3 4
  • Adenomatosis Polyposis Coli Down-Regulated 1 Protein-Like 4
  • Adenomatosis Polyposis Coli Down-Regulated 1-Like 2
  • Adenomatosis Polyposis Coli Down-Regulated 1 Like 3
  • FLJ90166 2
  • APCDD1L 5

External Ids for APCDD1L Gene

Previous GeneCards Identifiers for APCDD1L Gene

  • GC20M056468
  • GC20M057034
  • GC20M053817

Summaries for APCDD1L Gene

GeneCards Summary for APCDD1L Gene

APCDD1L (APC Down-Regulated 1 Like) is a Protein Coding gene. Diseases associated with APCDD1L include Amelogenesis Imperfecta, Type Ie. An important paralog of this gene is APCDD1.

Additional gene information for APCDD1L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APCDD1L Gene

Genomics for APCDD1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for APCDD1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APCDD1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for APCDD1L

Top Transcription factor binding sites by QIAGEN in the APCDD1L gene promoter:
  • AML1a
  • CUTL1
  • E47
  • En-1
  • FOXF2
  • GATA-6
  • HEN1
  • N-Myc
  • POU6F1 (c2)
  • Sox5

Genomic Locations for APCDD1L Gene

Genomic Locations for APCDD1L Gene
chr20:58,459,101-58,515,399
(GRCh38/hg38)
Size:
56,299 bases
Orientation:
Minus strand
chr20:57,034,157-57,090,187
(GRCh37/hg19)
Size:
56,031 bases
Orientation:
Minus strand

Genomic View for APCDD1L Gene

Genes around APCDD1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APCDD1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APCDD1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APCDD1L Gene

Proteins for APCDD1L Gene

  • Protein details for APCDD1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCL9-APCDL_HUMAN
    Recommended name:
    Protein APCDD1-like
    Protein Accession:
    Q8NCL9

    Protein attributes for APCDD1L Gene

    Size:
    501 amino acids
    Molecular mass:
    55635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APCDD1L Gene

Post-translational modifications for APCDD1L Gene

  • Glycosylation at Asn150
  • Modification sites at PhosphoSitePlus

Other Protein References for APCDD1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APCDD1L Gene

Domains & Families for APCDD1L Gene

Gene Families for APCDD1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for APCDD1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APCDD1L Gene

GenScript: Design optimal peptide antigens:
  • Adenomatosis polyposis coli down-regulated 1 protein-like (APCDL_HUMAN)
genes like me logo Genes that share domains with APCDD1L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for APCDD1L Gene

Function for APCDD1L Gene

Phenotypes From GWAS Catalog for APCDD1L Gene

Gene Ontology (GO) - Molecular Function for APCDD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017147 Wnt-protein binding IEA --
genes like me logo Genes that share ontologies with APCDD1L: view
genes like me logo Genes that share phenotypes with APCDD1L: view

Animal Model Products

CRISPR Products

miRNA for APCDD1L Gene

miRTarBase miRNAs that target APCDD1L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APCDD1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APCDD1L Gene

Localization for APCDD1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for APCDD1L Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APCDD1L gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1
peroxisome 0
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for APCDD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APCDD1L: view

Pathways & Interactions for APCDD1L Gene

PathCards logo

SuperPathways for APCDD1L Gene

No Data Available

Interacting Proteins for APCDD1L Gene

Selected Interacting proteins: Q8NCL9-APCDL_HUMAN for APCDD1L Gene via UniProtKB

Gene Ontology (GO) - Biological Process for APCDD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030178 negative regulation of Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with APCDD1L: view

No data available for Pathways by source and SIGNOR curated interactions for APCDD1L Gene

Drugs & Compounds for APCDD1L Gene

No Compound Related Data Available

Transcripts for APCDD1L Gene

mRNA/cDNA for APCDD1L Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APCDD1L

Alternative Splicing Database (ASD) splice patterns (SP) for APCDD1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for APCDD1L Gene

GeneLoc Exon Structure for
APCDD1L

Expression for APCDD1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for APCDD1L Gene

mRNA differential expression in normal tissues according to GTEx for APCDD1L Gene

This gene is overexpressed in Minor Salivary Gland (x8.7), Artery - Aorta (x8.3), and Bladder (x5.3).

Protein differential expression in normal tissues from HIPED for APCDD1L Gene

This gene is overexpressed in Frontal cortex (42.9) and Fetal testis (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APCDD1L Gene



Protein tissue co-expression partners for APCDD1L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APCDD1L

SOURCE GeneReport for Unigene cluster for APCDD1L Gene:

Hs.119286

Evidence on tissue expression from TISSUES for APCDD1L Gene

  • Heart(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with APCDD1L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for APCDD1L Gene

Orthologs for APCDD1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for APCDD1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia APCDD1L 30 31
  • 99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia APCDD1L 30 31
  • 84.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia APCDD1L 30 31
  • 81.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Apcdd1l 30
  • 75.39 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia APCDD1L 31
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia APCDD1L 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves APCDD1L 30
  • 68.57 (n)
PGO2 31
  • 60 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia APCDD1L 31
  • 60 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC100001408 30
  • 57.46 (n)
apcdd1l 31
  • 46 (a)
OneToOne
Species where no ortholog for APCDD1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for APCDD1L Gene

ENSEMBL:
Gene Tree for APCDD1L (if available)
TreeFam:
Gene Tree for APCDD1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for APCDD1L: view image

Paralogs for APCDD1L Gene

Paralogs for APCDD1L Gene

(1) SIMAP similar genes for APCDD1L Gene using alignment to 3 proteins:

  • APCDL_HUMAN
  • A2A2P3_HUMAN
  • F5H6V6_HUMAN
genes like me logo Genes that share paralogs with APCDD1L: view

Variants for APCDD1L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APCDD1L Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs16981999 - p.Arg261Cys
rs3946003 - p.Cys30Arg
rs7265854 - p.Tyr80His
rs7265902 - p.Arg83Gln

Additional dbSNP identifiers (rs#s) for APCDD1L Gene

Structural Variations from Database of Genomic Variants (DGV) for APCDD1L Gene

Variant ID Type Subtype PubMed ID
esv3389917 CNV duplication 20981092
nsv1063462 CNV gain 25217958
nsv1148136 CNV duplication 26484159
nsv3428 CNV deletion 18451855
nsv525781 CNV loss 19592680
nsv834019 CNV loss 17160897

Variation tolerance for APCDD1L Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APCDD1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APCDD1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APCDD1L Gene

Disorders for APCDD1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for APCDD1L Gene - From: DISEASES

Disorder Aliases PubMed IDs
amelogenesis imperfecta, type ie
  • ai1e
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for APCDD1L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with APCDD1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APCDD1L Gene

Publications for APCDD1L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. (PMID: 20838585) Smith EN … Murray SS (PLoS genetics 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4

Products for APCDD1L Gene

Sources for APCDD1L Gene