Free for academic non-profit institutions. Other users need a Commercial license

Aliases for APCDD1L Gene

Aliases for APCDD1L Gene

  • APC Down-Regulated 1 Like 2 3 5
  • Adenomatosis Polyposis Coli Down-Regulated 1 Protein-Like 4
  • Adenomatosis Polyposis Coli Down-Regulated 1 Like 3
  • Adenomatosis Polyposis Coli Down-Regulated 1-Like 2
  • Protein APCDD1-Like 3

External Ids for APCDD1L Gene

Previous GeneCards Identifiers for APCDD1L Gene

  • GC20M056468
  • GC20M057034
  • GC20M053817

Summaries for APCDD1L Gene

GeneCards Summary for APCDD1L Gene

APCDD1L (APC Down-Regulated 1 Like) is a Protein Coding gene. An important paralog of this gene is APCDD1.

Additional gene information for APCDD1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APCDD1L Gene

Genomics for APCDD1L Gene

GeneHancer (GH) Regulatory Elements for APCDD1L Gene

Promoters and enhancers for APCDD1L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J058515 Promoter/Enhancer 1.1 EPDnew dbSUPER 650.7 0.0 -26 0.1 SMARCE1 MAZ ZNF341 ZBTB33 MNT FOS KLF4 EZH2 APCDD1L APCDD1L-DT GC20M058516
GH20J058514 Promoter/Enhancer 1 EPDnew dbSUPER 658.1 +0.5 486 0.1 ZNF341 CTBP2 KLF4 ZBTB26 EZH2 APCDD1L APCDD1L-DT GC20M058516 VAPB
GH20J058541 Enhancer 1 Ensembl ENCODE dbSUPER 37.3 -26.6 -26636 1.2 SMARCE1 PKNOX1 JUN CEBPB EP300 FOSL1 JUND EGR1 SMARCA4 VEZF1 APCDD1L APCDD1L-DT GC20M058516 ENSG00000254620
GH20J058547 Enhancer 0.8 ENCODE dbSUPER 28.4 -32.7 -32654 1.3 EP300 MAFF JUND ZNF341 ZNF24 RCOR1 CHD2 DEK APCDD1L APCDD1L-DT GC20M058516 ENSG00000254620
GH20J058549 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 17.1 -35.1 -35125 1.3 NFIB MAX ZIC2 RFX5 FOSL1 GATA3 VEZF1 HSF1 SMC3 RCOR1 APCDD1L APCDD1L-DT GC20M058516 ENSG00000254620
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APCDD1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the APCDD1L gene promoter:
  • HEN1
  • GATA-6
  • Sox5
  • AML1a
  • En-1
  • FOXF2
  • POU6F1 (c2)
  • E47
  • N-Myc
  • CUTL1

Genomic Locations for APCDD1L Gene

Genomic Locations for APCDD1L Gene
62,925 bases
Minus strand
56,031 bases
Minus strand

Genomic View for APCDD1L Gene

Genes around APCDD1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APCDD1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APCDD1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APCDD1L Gene

Proteins for APCDD1L Gene

  • Protein details for APCDD1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein APCDD1-like
    Protein Accession:

    Protein attributes for APCDD1L Gene

    501 amino acids
    Molecular mass:
    55635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APCDD1L Gene

Post-translational modifications for APCDD1L Gene

  • Glycosylation at Asn150
  • Modification sites at PhosphoSitePlus

Other Protein References for APCDD1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APCDD1L Gene

Domains & Families for APCDD1L Gene

Gene Families for APCDD1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for APCDD1L Gene


Suggested Antigen Peptide Sequences for APCDD1L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APCDD1L: view

No data available for UniProtKB/Swiss-Prot for APCDD1L Gene

Function for APCDD1L Gene

genes like me logo Genes that share phenotypes with APCDD1L: view

Animal Model Products

CRISPR Products

miRNA for APCDD1L Gene

miRTarBase miRNAs that target APCDD1L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APCDD1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APCDD1L Gene

Localization for APCDD1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for APCDD1L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APCDD1L gene
Compartment Confidence
plasma membrane 2
extracellular 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for APCDD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APCDD1L: view

Pathways & Interactions for APCDD1L Gene

SuperPathways for APCDD1L Gene

No Data Available

Interacting Proteins for APCDD1L Gene

Gene Ontology (GO) - Biological Process for APCDD1L Gene


No data available for Pathways by source and SIGNOR curated interactions for APCDD1L Gene

Drugs & Compounds for APCDD1L Gene

No Compound Related Data Available

Transcripts for APCDD1L Gene

mRNA/cDNA for APCDD1L Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APCDD1L Gene

Adenomatosis polyposis coli down-regulated 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APCDD1L

Alternative Splicing Database (ASD) splice patterns (SP) for APCDD1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -

Relevant External Links for APCDD1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APCDD1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APCDD1L Gene

mRNA differential expression in normal tissues according to GTEx for APCDD1L Gene

This gene is overexpressed in Minor Salivary Gland (x8.7), Artery - Aorta (x8.3), and Bladder (x5.3).

Protein differential expression in normal tissues from HIPED for APCDD1L Gene

This gene is overexpressed in Frontal cortex (42.9) and Fetal testis (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APCDD1L Gene

Protein tissue co-expression partners for APCDD1L Gene

NURSA nuclear receptor signaling pathways regulating expression of APCDD1L Gene:


SOURCE GeneReport for Unigene cluster for APCDD1L Gene:


Evidence on tissue expression from TISSUES for APCDD1L Gene

  • Heart(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with APCDD1L: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for APCDD1L Gene

Orthologs for APCDD1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for APCDD1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APCDD1L 34 33
  • 99 (n)
(Canis familiaris)
Mammalia APCDD1L 34 33
  • 84.87 (n)
(Bos Taurus)
Mammalia APCDD1L 34 33
  • 81.93 (n)
(Rattus norvegicus)
Mammalia Apcdd1l 33
  • 75.39 (n)
(Ornithorhynchus anatinus)
Mammalia APCDD1L 34
  • 65 (a)
(Monodelphis domestica)
Mammalia APCDD1L 34
  • 61 (a)
(Gallus gallus)
Aves APCDD1L 33
  • 68.57 (n)
PGO2 34
  • 60 (a)
(Anolis carolinensis)
Reptilia APCDD1L 34
  • 60 (a)
(Danio rerio)
Actinopterygii LOC100001408 33
  • 57.46 (n)
apcdd1l 34
  • 46 (a)
Species where no ortholog for APCDD1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APCDD1L Gene

Gene Tree for APCDD1L (if available)
Gene Tree for APCDD1L (if available)
Evolutionary constrained regions (ECRs) for APCDD1L: view image

Paralogs for APCDD1L Gene

Paralogs for APCDD1L Gene

(1) SIMAP similar genes for APCDD1L Gene using alignment to 3 proteins:

  • A2A2P3_HUMAN
  • F5H6V6_HUMAN
genes like me logo Genes that share paralogs with APCDD1L: view

Variants for APCDD1L Gene

Sequence variations from dbSNP and Humsavar for APCDD1L Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000007159 -- 58,458,807(-) G/A/T downstream_transcript_variant
rs1000226090 -- 58,460,235(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000246984 -- 58,514,955(-) G/T upstream_transcript_variant
rs1000341140 -- 58,465,139(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000400206 -- 58,508,982(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for APCDD1L Gene

Variant ID Type Subtype PubMed ID
esv3389917 CNV duplication 20981092
nsv1063462 CNV gain 25217958
nsv1148136 CNV duplication 26484159
nsv3428 CNV deletion 18451855
nsv525781 CNV loss 19592680
nsv834019 CNV loss 17160897

Variation tolerance for APCDD1L Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APCDD1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APCDD1L Gene

Disorders for APCDD1L Gene

Additional Disease Information for APCDD1L

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for APCDD1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APCDD1L Gene

Publications for APCDD1L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. (PMID: 20838585) Smith EN … Murray SS (PLoS genetics 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for APCDD1L Gene

Sources for APCDD1L Gene

Loading form....