Aliases for APBB2 Gene
External Ids for APBB2 Gene
Previous GeneCards Identifiers for APBB2 Gene
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
GeneCards Summary for APBB2 Gene
APBB2 (Amyloid Beta Precursor Protein Binding Family B Member 2) is a Protein Coding gene. Diseases associated with APBB2 include Alzheimer Disease and Giant Axonal Neuropathy. Gene Ontology (GO) annotations related to this gene include transcription factor binding and amyloid-beta binding. An important paralog of this gene is APBB1.
UniProtKB/Swiss-Prot Summary for APBB2 Gene
May modulate the internalization of amyloid-beta precursor protein.