This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated c... See more...

Aliases for APAF1 Gene

Aliases for APAF1 Gene

  • Apoptotic Peptidase Activating Factor 1 2 3 5
  • Apoptotic Protease-Activating Factor 1 3 4
  • APAF-1 3 4
  • Apoptotic Peptidase Activating Factor 2
  • Apoptotic Protease Activating Factor 2
  • KIAA0413 4
  • CED4 3

External Ids for APAF1 Gene

Previous GeneCards Identifiers for APAF1 Gene

  • GC12P098489
  • GC12P099542
  • GC12P098971
  • GC12P097541
  • GC12P099039
  • GC12P096100

Summaries for APAF1 Gene

Entrez Gene Summary for APAF1 Gene

  • This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for APAF1 Gene

APAF1 (Apoptotic Peptidase Activating Factor 1) is a Protein Coding gene. Diseases associated with APAF1 include Dystrophinopathies and Retinal Ischemia. Among its related pathways are Direct p53 effectors and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and ADP binding.

UniProtKB/Swiss-Prot Summary for APAF1 Gene

  • Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.

Gene Wiki entry for APAF1 Gene

Additional gene information for APAF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for APAF1 Gene

Genomics for APAF1 Gene

GeneHancer (GH) Regulatory Elements for APAF1 Gene

Promoters and enhancers for APAF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J098643 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 0.0 -40 5 ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 POLR2G SP1 PHF8 FOS ZFX IKBIP APAF1 FJ601684-083 SLC25A3 TMPO PPIAP8 piR-35674-113
GH12J098592 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -50.6 -50640 4.6 ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G SP1 GTF2E2 PHF8 SLC25A3 HSALNG0093396 lnc-IKBIP-9 TMPO IKBIP APAF1 TMPO-AS1
GH12J098532 Enhancer 1 Ensembl ENCODE 10 -111.6 -111570 1.8 CTCF TRIM28 REST EP300 CTBP1 TRIM22 SMC3 ZBTB17 ARNT CEBPG RNU4-41P LINC02453 SNORA53 APAF1 IKBIP SLC9A7P1 piR-61861-008 lnc-IKBIP-11 TMPO
GH12J098605 Enhancer 0.7 Ensembl ENCODE 12.1 -38.2 -38163 2.4 RAD21 CTCF CEBPB SPI1 ZFHX2 ZNF654 BCL6 SMC3 MAX BCL6B lnc-IKBIP-1 IKBIP APAF1 SLC25A3 FJ601684-083
GH12J098612 Enhancer 0.7 ENCODE 12.2 -32.2 -32174 1 ZNF384 ARNT MEF2B NBN SPI1 NR2C1 ELF1 EBF1 IKZF1 POLR2A APAF1 IKBIP lnc-IKBIP-1 FJ601684-083
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APAF1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for APAF1

Top Transcription factor binding sites by QIAGEN in the APAF1 gene promoter:
  • AP-1
  • ATF-2
  • HEN1
  • RORalpha1
  • Sox5
  • STAT3

Genomic Locations for APAF1 Gene

Genomic Locations for APAF1 Gene
chr12:98,645,141-98,735,433
(GRCh38/hg38)
Size:
90,293 bases
Orientation:
Plus strand
chr12:99,038,919-99,129,211
(GRCh37/hg19)
Size:
90,293 bases
Orientation:
Plus strand

Genomic View for APAF1 Gene

Genes around APAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APAF1 Gene

Proteins for APAF1 Gene

  • Protein details for APAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14727-APAF_HUMAN
    Recommended name:
    Apoptotic protease-activating factor 1
    Protein Accession:
    O14727
    Secondary Accessions:
    • B2RMX8
    • O43297
    • Q7Z438
    • Q9BXZ6
    • Q9UBZ5
    • Q9UGN8
    • Q9UGN9
    • Q9UGP0
    • Q9UJ58
    • Q9UJ59
    • Q9UJ60
    • Q9UJ61
    • Q9UJ62
    • Q9UJ63
    • Q9UJ64
    • Q9UJ65
    • Q9UJ66
    • Q9UJ67
    • Q9UNC9

    Protein attributes for APAF1 Gene

    Size:
    1248 amino acids
    Molecular mass:
    141840 Da
    Quaternary structure:
    • Monomer. Oligomerizes to a heptameric ring, known as the apoptosome, upon binding of cytochrome c and dATP. Oligomeric Apaf-1 and pro-caspase-9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase-9 is released from the complex. Pro-caspase-3 is recruited into the Apaf-1-pro-caspase-9 complex via interaction with pro-caspase-9. Interacts with APIP. Interacts (via CARD and NACHT domains) with NAIP/BIRC1 (via NACHT domain). Interacts with CIAO2A (PubMed:25716227).
    Miscellaneous:
    • Physiological concentrations of calcium ions negatively affect the assembly of apoptosome by inhibiting nucleotide exchange in the monomeric form.
    SequenceCaution:
    • Sequence=AAK28401.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for APAF1 Gene

    Alternative splice isoforms for APAF1 Gene

neXtProt entry for APAF1 Gene

Post-translational modifications for APAF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for APAF1

No data available for DME Specific Peptides for APAF1 Gene

Domains & Families for APAF1 Gene

Gene Families for APAF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for APAF1 Gene

Blocks:
  • G-protein beta WD-40 repeat signature
  • Disease resistance protein signature
  • CARD interaction domain
  • NB-ARC domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APAF1 Gene

GenScript: Design optimal peptide antigens:
  • APAF1 protein (A5YM44_HUMAN)
  • Apoptotic peptidase activating factor 1 (A7E2A2_HUMAN)
  • Apoptotic protease-activating factor 1 (APAF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14727

UniProtKB/Swiss-Prot:

APAF_HUMAN :
  • The CARD domain mediates interaction with APIP.
Domain:
  • The CARD domain mediates interaction with APIP.
  • The monomeric form is autoinhibited in a closed conformation through a bound ADP at the nucleotide binding site. Exchange of ADP for ATP and binding of cytochrome c trigger a large conformational change where the first WD repeat region swings out, allowing the NB-ARC domain to rotate and expose the contact areas for oligomerization (By similarity).
genes like me logo Genes that share domains with APAF1: view

Function for APAF1 Gene

Molecular function for APAF1 Gene

UniProtKB/Swiss-Prot Function:
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
UniProtKB/Swiss-Prot Induction:
By E2F and p53/TP53 in apoptotic neurons (PubMed:11389439). Tranlation is inhibited by HNRPA1, which binds to the IRES of APAF1 mRNAs (PubMed:31498791).
GENATLAS Biochemistry:
cytoplasmic scaffolding apoptotic protease activating factor 1,89kDa,forming a ternary complex ATP,datp dependent with cytochrome C1 and the initiator of apoptosis caspase 9,not inhibited by binding to BCL2

Phenotypes From GWAS Catalog for APAF1 Gene

Gene Ontology (GO) - Molecular Function for APAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 10383829
GO:0005515 protein binding IPI,IEA 9267021
GO:0005524 ATP binding IEA --
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process NAS,TAS 15009102
GO:0031072 heat shock protein binding IEA --
genes like me logo Genes that share ontologies with APAF1: view
genes like me logo Genes that share phenotypes with APAF1: view

Animal Models for APAF1 Gene

MGI Knock Outs for APAF1:

Animal Model Products

CRISPR Products

miRNA for APAF1 Gene

miRTarBase miRNAs that target APAF1

Clone Products

  • Addgene plasmids for APAF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APAF1 Gene

Localization for APAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APAF1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APAF1 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
plasma membrane 3
mitochondrion 3
golgi apparatus 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for APAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0032991 protein-containing complex IDA 11821383
genes like me logo Genes that share ontologies with APAF1: view

Pathways & Interactions for APAF1 Gene

PathCards logo

SuperPathways for APAF1 Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
.87
.87
.56
.55
.52
.42
.42
.40
.35
2 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
3 Apoptosis Modulation and Signaling
.41
.31
4 Nanomaterial induced apoptosis
5 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.74
genes like me logo Genes that share pathways with APAF1: view

Pathways by source for APAF1 Gene

6 GeneGo (Thomson Reuters) pathways for APAF1 Gene
  • Apoptosis and survival Caspase cascade
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival Role of CDK5 in neuronal death and survival
  • Apoptosis and survival TNFR1 signaling pathway
1 R&D Systems pathway for APAF1 Gene
22 Qiagen pathways for APAF1 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Apoptosis through Death Receptors
  • Apoptotic Pathways Triggered By HIV1
  • BAD Phosphorylation
  • Caspase Cascade
1 Cell Signaling Technology pathway for APAF1 Gene
2 GeneTex pathways for APAF1 Gene

SIGNOR curated interactions for APAF1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for APAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001822 kidney development IEA --
GO:0001843 neural tube closure IEA --
GO:0006915 apoptotic process TAS 9753320
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 21827945
genes like me logo Genes that share ontologies with APAF1: view

Drugs & Compounds for APAF1 Gene

(23) Drugs for APAF1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dATP Experimental Pharma Full agonist, Agonist 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation, Target 0

(18) Additional Compounds for APAF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APAF1: view

Transcripts for APAF1 Gene

mRNA/cDNA for APAF1 Gene

5 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for APAF1

Alternative Splicing Database (ASD) splice patterns (SP) for APAF1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - - - - -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for APAF1 Gene

GeneLoc Exon Structure for
APAF1

Expression for APAF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for APAF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APAF1 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for APAF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.4) and Lymph node (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APAF1 Gene



Protein tissue co-expression partners for APAF1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for APAF1

SOURCE GeneReport for Unigene cluster for APAF1 Gene:

Hs.552567

mRNA Expression by UniProt/SwissProt for APAF1 Gene:

O14727-APAF_HUMAN
Tissue specificity: Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.

Evidence on tissue expression from TISSUES for APAF1 Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Heart(4.4)
  • Kidney(4.4)
  • Intestine(2.2)
  • Liver(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with APAF1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APAF1 Gene

Orthologs for APAF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for APAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APAF1 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia APAF1 31 30
  • 91.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia APAF1 31 30
  • 90.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Apaf1 17 31 30
  • 86 (n)
rat
(Rattus norvegicus)
Mammalia Apaf1 30
  • 85.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia APAF1 31
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APAF1 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves APAF1 31 30
  • 72.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APAF1 31
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apaf1 30
  • 67.19 (n)
zebrafish
(Danio rerio)
Actinopterygii apaf1 31 30
  • 59.54 (n)
OneToOne
-- 30
fruit fly
(Drosophila melanogaster)
Insecta CG30116 31
  • 10 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea qui-1 31
  • 8 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIP2 31
  • 15 (a)
OneToMany
Species where no ortholog for APAF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APAF1 Gene

ENSEMBL:
Gene Tree for APAF1 (if available)
TreeFam:
Gene Tree for APAF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for APAF1: view image

Paralogs for APAF1 Gene

(3) SIMAP similar genes for APAF1 Gene using alignment to 6 proteins:

  • APAF_HUMAN
  • A5YM44_HUMAN
  • A7E2A2_HUMAN
  • C9JLV4_HUMAN
  • F8VNZ0_HUMAN
  • L8E801_HUMAN
genes like me logo Genes that share paralogs with APAF1: view

No data available for Paralogs for APAF1 Gene

Variants for APAF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for APAF1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
709456 Benign: not provided 98,715,542(+) C/A MISSENSE_VARIANT,INTRON_VARIANT
712181 Benign: not provided 98,677,505(+) A/C MISSENSE_VARIANT,INTRON_VARIANT
719386 Likely Benign: not provided 98,725,431(+) T/C MISSENSE_VARIANT,INTRON_VARIANT
732993 Likely Benign: not provided 98,706,501(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
744827 Likely Benign: not provided 98,699,539(+) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for APAF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for APAF1 Gene

Variant ID Type Subtype PubMed ID
esv2746267 CNV deletion 23290073
nsv1051515 CNV gain 25217958
nsv455696 CNV loss 19166990
nsv559918 CNV loss 21841781
nsv559919 CNV loss 21841781
nsv559920 CNV loss 21841781
nsv832496 CNV gain 17160897
nsv844 CNV insertion 18451855

Variation tolerance for APAF1 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APAF1 Gene

Human Gene Mutation Database (HGMD)
APAF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
APAF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APAF1 Gene

Disorders for APAF1 Gene

MalaCards: The human disease database

(21) MalaCards diseases for APAF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dystrophinopathies
  • dystrophinopathy
retinal ischemia
lung cancer
  • adenocarcinoma of lung
neural tube defects
  • neural tube defects, susceptibility to
fibrosarcoma
  • fibrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search APAF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for APAF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with APAF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APAF1 Gene

Publications for APAF1 Gene

  1. Allelic imbalance of 12q22-23 associated with APAF-1 locus correlates with poor disease outcome in cutaneous melanoma. (PMID: 15026369) Fujimoto A … Hoon DS (Cancer research 2004) 3 23 41 54
  2. APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line. (PMID: 12804598) Ogawa T … Furukawa T (Biochemical and biophysical research communications 2003) 3 4 23 54
  3. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. (PMID: 10393175) Hu Y … Núñez G (The EMBO journal 1999) 3 4 23 54
  4. Three new types of Apaf-1 in mammalian cells. (PMID: 10441496) Hahn C … Stein H (Biochemical and biophysical research communications 1999) 3 4 23 54
  5. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. (PMID: 10364241) Saleh A … Alnemri ES (The Journal of biological chemistry 1999) 3 4 23 54

Products for APAF1 Gene

  • Addgene plasmids for APAF1

Sources for APAF1 Gene