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Aliases for AP5M1 Gene

Aliases for AP5M1 Gene

  • Adaptor Related Protein Complex 5 Mu 1 Subunit 2 3 5
  • Adaptor-Related Protein Complex 5 Subunit Mu-1 3 4
  • MU-2/AP1M2 Domain Containing, Death-Inducing 2 3
  • Putative HIV-1 Infection-Related Protein 3 4
  • Mu-2-Related Death-Inducing Protein 3 4
  • C14orf108 3 4
  • MUDENG 3 4
  • Mu5 3 4
  • MuD 3 4
  • Adaptor-Related Protein Complex 5, Mu 1 Subunit 2
  • Adapter-Related Protein Complex 5 Subunit Mu-1 3
  • MHD Domain-Containing Death-Inducing Protein 3
  • Adapter-Related Protein Complex 5 Mu Subunit 3
  • Chromosome 14 Open Reading Frame 108 2
  • Mu-2 Related Death-Inducing Gene 2
  • Mu-2 Related Death-Inducing 3
  • AP-5 Complex Subunit Mu-1 3
  • AP-5 Complex Subunit Mu 3

External Ids for AP5M1 Gene

Previous HGNC Symbols for AP5M1 Gene

  • C14orf108

Previous GeneCards Identifiers for AP5M1 Gene

  • GC14P057737

Summaries for AP5M1 Gene

GeneCards Summary for AP5M1 Gene

AP5M1 (Adaptor Related Protein Complex 5 Mu 1 Subunit) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AP5M1 Gene

  • As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.

Additional gene information for AP5M1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP5M1 Gene

Genomics for AP5M1 Gene

GeneHancer (GH) Regulatory Elements for AP5M1 Gene

Promoters and enhancers for AP5M1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I057264 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 557 -1.3 -1314 6.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 E2F8 AP5M1 EXOC5 NAA30 ENSG00000258592
GH14I057290 Enhancer 0.7 UCNEbase ENCODE 11.7 +21.8 21792 1.1 EZH2 EXOC5 AP5M1 GC14P057276 GC14P057307 PIR52540
GH14I057382 Enhancer 0.7 Ensembl ENCODE 9.7 +113.6 113613 0.6 FOSL1 ZNF146 JUND ZNF3 JUN USF2 FOS AP5M1 EXOC5 NAA30 ENSG00000259008
GH14I057383 Enhancer 0.3 Ensembl 15.8 +114.4 114413 0.2 TCF7 AP5M1 EXOC5 NAA30 ENSG00000259008
GH14I057259 Enhancer 0.6 FANTOM5 5.4 -9.6 -9627 0.4 SMARCE1 CBFA2T3 DPF2 ZEB2 FOSL1 TCF12 NCOR1 SMARCA4 PRDM10 FOS AP5M1 EXOC5 ENSG00000258592
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AP5M1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AP5M1 Gene

Genomic Locations for AP5M1 Gene
29,855 bases
Plus strand

Genomic View for AP5M1 Gene

Genes around AP5M1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP5M1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP5M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP5M1 Gene

Proteins for AP5M1 Gene

  • Protein details for AP5M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AP-5 complex subunit mu-1
    Protein Accession:
    Secondary Accessions:
    • O95354
    • Q6ZMD7
    • Q96DX3
    • Q9NVC5

    Protein attributes for AP5M1 Gene

    490 amino acids
    Molecular mass:
    54767 Da
    Quaternary structure:
    • Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.
    • Sequence=BAD18791.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18791.1; Type=Frameshift; Positions=482; Evidence={ECO:0000305};

    Alternative splice isoforms for AP5M1 Gene


neXtProt entry for AP5M1 Gene

Post-translational modifications for AP5M1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for AP5M1 Gene

Domains & Families for AP5M1 Gene

Gene Families for AP5M1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AP5M1 Gene


Suggested Antigen Peptide Sequences for AP5M1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the adaptor complexes medium subunit family.
  • Belongs to the adaptor complexes medium subunit family.
genes like me logo Genes that share domains with AP5M1: view

Function for AP5M1 Gene

Molecular function for AP5M1 Gene

UniProtKB/Swiss-Prot Function:
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.

Phenotypes for AP5M1 Gene

genes like me logo Genes that share phenotypes with AP5M1: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AP5M1 Gene

Localization for AP5M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP5M1 Gene

Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=May cycle on and off membranes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AP5M1 gene
Compartment Confidence
cytosol 5
lysosome 5
endosome 5
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for AP5M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA,IDA 22022230
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005770 late endosome IDA 22022230
GO:0005829 cytosol IDA,IEA 22022230
genes like me logo Genes that share ontologies with AP5M1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AP5M1 Gene

Pathways & Interactions for AP5M1 Gene

SuperPathways for AP5M1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AP5M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016197 endosomal transport IMP 22022230
genes like me logo Genes that share ontologies with AP5M1: view

No data available for Pathways by source and SIGNOR curated interactions for AP5M1 Gene

Drugs & Compounds for AP5M1 Gene

No Compound Related Data Available

Transcripts for AP5M1 Gene

Unigene Clusters for AP5M1 Gene

Adaptor-related protein complex 5, mu 1 subunit:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP5M1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP3: - - - -
SP6: -

Relevant External Links for AP5M1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AP5M1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AP5M1 Gene

Protein differential expression in normal tissues from HIPED for AP5M1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.4), Lymph node (19.4), Blymphocyte (16.5), and Spinal cord (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AP5M1 Gene

Protein tissue co-expression partners for AP5M1 Gene

NURSA nuclear receptor signaling pathways regulating expression of AP5M1 Gene:


SOURCE GeneReport for Unigene cluster for AP5M1 Gene:


mRNA Expression by UniProt/SwissProt for AP5M1 Gene:

Tissue specificity: Expressed in various tumor cell lines including Jurkat, Hep-G2 and HeLa.

Evidence on tissue expression from TISSUES for AP5M1 Gene

  • Nervous system(4.9)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with AP5M1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AP5M1 Gene

Orthologs for AP5M1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AP5M1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AP5M1 33 34
  • 99.73 (n)
(Canis familiaris)
Mammalia AP5M1 33 34
  • 91.02 (n)
(Bos Taurus)
Mammalia AP5M1 33 34
  • 90.48 (n)
(Mus musculus)
Mammalia Ap5m1 33 16 34
  • 86.3 (n)
(Rattus norvegicus)
Mammalia Ap5m1 33
  • 85.14 (n)
(Monodelphis domestica)
Mammalia AP5M1 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia AP5M1 34
  • 72 (a)
(Gallus gallus)
Aves MUDENG 33
  • 67.32 (n)
AP5M1 34
  • 63 (a)
(Anolis carolinensis)
Reptilia AP5M1 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ap5m1 33
  • 64.74 (n)
Str.20418 33
(Danio rerio)
Actinopterygii ap5m1 33 34
  • 57.43 (n)
Dr.13330 33
Species where no ortholog for AP5M1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AP5M1 Gene

Gene Tree for AP5M1 (if available)
Gene Tree for AP5M1 (if available)

Paralogs for AP5M1 Gene Pseudogenes for AP5M1 Gene

genes like me logo Genes that share paralogs with AP5M1: view

No data available for Paralogs for AP5M1 Gene

Variants for AP5M1 Gene

Sequence variations from dbSNP and Humsavar for AP5M1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000106258 -- 57,289,666(+) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000158968 -- 57,284,186(+) A/C intron_variant
rs1000311889 -- 57,277,758(+) G/T intron_variant
rs1000385233 -- 57,291,343(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000441974 -- 57,283,762(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AP5M1 Gene

Variant ID Type Subtype PubMed ID
esv2429208 CNV insertion 19546169
nsv1046422 CNV gain 25217958
nsv832806 CNV loss 17160897

Variation tolerance for AP5M1 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AP5M1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP5M1 Gene

Disorders for AP5M1 Gene

Additional Disease Information for AP5M1

No disorders were found for AP5M1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AP5M1 Gene

Publications for AP5M1 Gene

  1. A novel protein, MUDENG, induces cell death in cytotoxic T cells. (PMID: 18395520) Lee MR … Kim TH (Biochemical and biophysical research communications 2008) 2 3 4 58
  2. The fifth adaptor protein complex. (PMID: 22022230) Hirst J … Robinson MS (PLoS biology 2011) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for AP5M1 Gene

Sources for AP5M1 Gene

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