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Aliases for AP3B1 Gene

Aliases for AP3B1 Gene

  • Adaptor Related Protein Complex 3 Subunit Beta 1 2 3
  • Adaptor Related Protein Complex 3 Beta 1 Subunit 2 3 5
  • Clathrin Assembly Protein Complex 3 Beta-1 Large Chain 3 4
  • Adaptor Protein Complex AP-3 Subunit Beta-1 3 4
  • Beta-3A-Adaptin 3 4
  • ADTB3A 3 4
  • Adaptor-Related Protein Complex 3 Subunit Beta-1 4
  • AP-3 Complex Beta-3A Subunit 3
  • AP-3 Complex Subunit Beta-1 3
  • ADTB3 3
  • HPS2 3
  • HPS 3
  • PE 3

External Ids for AP3B1 Gene

Previous GeneCards Identifiers for AP3B1 Gene

  • GC05M076103
  • GC05M077532
  • GC05M077336
  • GC05M077383
  • GC05M077384
  • GC05M077333
  • GC05M077296
  • GC05M072504

Summaries for AP3B1 Gene

Entrez Gene Summary for AP3B1 Gene

  • This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for AP3B1 Gene

AP3B1 (Adaptor Related Protein Complex 3 Subunit Beta 1) is a Protein Coding gene. Diseases associated with AP3B1 include Hermansky-Pudlak Syndrome 2 and Hermansky-Pudlak Syndrome. Among its related pathways are HIV Life Cycle and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include binding and GTP-dependent protein binding. An important paralog of this gene is AP3B2.

UniProtKB/Swiss-Prot for AP3B1 Gene

  • Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Gene Wiki entry for AP3B1 Gene

Additional gene information for AP3B1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP3B1 Gene

Genomics for AP3B1 Gene

GeneHancer (GH) Regulatory Elements for AP3B1 Gene

Promoters and enhancers for AP3B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J078293 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 656.9 0.0 -13 2.9 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NBN NR2C1 KDM1A AP3B1 RPS3AP20 JMY RPL7P23 ENSG00000251605
GH05J077645 Enhancer 1.6 VISTA UCNEbase 11.7 +649.5 649464 0.6 HDGF ARNT YBX1 GLI4 ZNF2 ZNF416 ZNF143 KLF7 ZNF548 ZNF202 RPL7P23 SCAMP1 WDR41 AP3B1 AGGF1 OTP GC05M077675
GH05J078503 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.9 -213.3 -213273 8.5 HDGF FEZF1 ZNF2 YY1 ZNF213 FOS ZNF263 REST ZNF592 ZNF610 LHFPL2 PIR51536 SCAMP1-AS1 SCAMP1 ARSB AP3B1
GH05J078222 Enhancer 0.8 ENCODE 6.9 +72.5 72483 0.3 HDGF HDAC1 PKNOX1 RB1 STAT5A BMI1 BATF RAD21 IRF4 ATF7 ATP6V1G1P6 AP3B1 GC05M078230 GC05M078176
GH05J078287 Enhancer 0.8 Ensembl ENCODE 6.6 +6.6 6637 1.2 ZNF384 ZNF664 PRDM6 MAFF JUND ZNF600 FOS MAFK GC05M078176 AP3B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AP3B1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AP3B1 gene promoter:
  • HNF-4alpha1
  • FOXO1a
  • FOXO1
  • Sox5
  • Arnt
  • AhR
  • ATF
  • ZIC2
  • Nkx2-5

Genomic Locations for AP3B1 Gene

Genomic Locations for AP3B1 Gene
chr5:78,000,525-78,294,755
(GRCh38/hg38)
Size:
294,231 bases
Orientation:
Minus strand
chr5:77,296,349-77,590,579
(GRCh37/hg19)
Size:
294,231 bases
Orientation:
Minus strand

Genomic View for AP3B1 Gene

Genes around AP3B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP3B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP3B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP3B1 Gene

Proteins for AP3B1 Gene

  • Protein details for AP3B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00203-AP3B1_HUMAN
    Recommended name:
    AP-3 complex subunit beta-1
    Protein Accession:
    O00203
    Secondary Accessions:
    • E5RJ68
    • O00580
    • Q7Z393
    • Q9HD66

    Protein attributes for AP3B1 Gene

    Size:
    1094 amino acids
    Molecular mass:
    121320 Da
    Quaternary structure:
    • AP-3 associates with the BLOC-1 complex (By similarity). Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).
    SequenceCaution:
    • Sequence=CAD97982.1; Type=Frameshift; Positions=1011; Evidence={ECO:0000305}; Sequence=CAD97982.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for AP3B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP3B1 Gene

Post-translational modifications for AP3B1 Gene

  • Phosphorylated on serine residues.
  • Ubiquitination at Lys596, Lys552, posLast=523523, and Lys512
  • Modification sites at PhosphoSitePlus

Other Protein References for AP3B1 Gene

No data available for DME Specific Peptides for AP3B1 Gene

Domains & Families for AP3B1 Gene

Gene Families for AP3B1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for AP3B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00203

UniProtKB/Swiss-Prot:

AP3B1_HUMAN :
  • Belongs to the adaptor complexes large subunit family.
Family:
  • Belongs to the adaptor complexes large subunit family.
genes like me logo Genes that share domains with AP3B1: view

Function for AP3B1 Gene

Molecular function for AP3B1 Gene

UniProtKB/Swiss-Prot Function:
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Phenotypes From GWAS Catalog for AP3B1 Gene

Gene Ontology (GO) - Molecular Function for AP3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019903 protein phosphatase binding IPI 17622474
GO:0030742 GTP-dependent protein binding IPI 22511774
genes like me logo Genes that share ontologies with AP3B1: view
genes like me logo Genes that share phenotypes with AP3B1: view

Human Phenotype Ontology for AP3B1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AP3B1 Gene

MGI Knock Outs for AP3B1:

Animal Model Products

Clone Products

  • Addgene plasmids for AP3B1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AP3B1 Gene

Localization for AP3B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP3B1 Gene

Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AP3B1 gene
Compartment Confidence
lysosome 5
golgi apparatus 5
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AP3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane HDA 17897319
GO:0005794 Golgi apparatus TAS,IEA --
GO:0016020 membrane HDA,IEA 19946888
GO:0030117 membrane coat IEA --
GO:0030123 AP-3 adaptor complex IEA --
genes like me logo Genes that share ontologies with AP3B1: view

Pathways & Interactions for AP3B1 Gene

genes like me logo Genes that share pathways with AP3B1: view

Pathways by source for AP3B1 Gene

Gene Ontology (GO) - Biological Process for AP3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006622 protein targeting to lysosome IEA --
GO:0006886 intracellular protein transport TAS 9931340
GO:0007596 blood coagulation IEA --
GO:0008089 anterograde axonal transport ISS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with AP3B1: view

No data available for SIGNOR curated interactions for AP3B1 Gene

Drugs & Compounds for AP3B1 Gene

No Compound Related Data Available

Transcripts for AP3B1 Gene

Unigene Clusters for AP3B1 Gene

Adaptor-related protein complex 3, beta 1 subunit:
Representative Sequences:

Clone Products

  • Addgene plasmids for AP3B1

Alternative Splicing Database (ASD) splice patterns (SP) for AP3B1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: -
SP2:

ExUns: 26 ^ 27
SP1:
SP2:

Relevant External Links for AP3B1 Gene

GeneLoc Exon Structure for
AP3B1
ECgene alternative splicing isoforms for
AP3B1

Expression for AP3B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AP3B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AP3B1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AP3B1 Gene



Protein tissue co-expression partners for AP3B1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AP3B1 Gene:

AP3B1

SOURCE GeneReport for Unigene cluster for AP3B1 Gene:

Hs.532091

mRNA Expression by UniProt/SwissProt for AP3B1 Gene:

O00203-AP3B1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for AP3B1 Gene

  • Blood(4.3)
  • Heart(4.2)
  • Intestine(4.2)
  • Pancreas(4.2)
  • Nervous system(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for AP3B1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • skull
  • tooth
Thorax:
  • lung
Abdomen:
  • liver
  • spleen
Pelvis:
  • pelvis
Limb:
  • femur
  • hip
  • lower limb
  • thigh
General:
  • blood
  • coagulation system
  • hair
  • peripheral nervous system
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with AP3B1: view

No data available for mRNA differential expression in normal tissues for AP3B1 Gene

Orthologs for AP3B1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AP3B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP3B1 34 33
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AP3B1 34 33
  • 91.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AP3B1 34 33
  • 90.84 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AP3B1 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap3b1 16 34 33
  • 84.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AP3B1 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves AP3B1 34 33
  • 75.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP3B1 34
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AP3B1 34
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rb 34 35 33
  • 60 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apb-3 34
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APL6 36 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5012 34
  • 52 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes apl6 33
  • 45.39 (n)
Species where no ortholog for AP3B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AP3B1 Gene

ENSEMBL:
Gene Tree for AP3B1 (if available)
TreeFam:
Gene Tree for AP3B1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AP3B1: view image

Paralogs for AP3B1 Gene

Paralogs for AP3B1 Gene

(3) SIMAP similar genes for AP3B1 Gene using alignment to 4 proteins:

  • AP3B1_HUMAN
  • E5RJ68_HUMAN
  • H0YBD0_HUMAN
  • L8EA53_HUMAN
genes like me logo Genes that share paralogs with AP3B1: view

Variants for AP3B1 Gene

Sequence variations from dbSNP and Humsavar for AP3B1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs111935323 benign, likely-benign, not specified, Hermansky-Pudlak syndrome, Hermansky Pudlak syndrome 2 78,015,516(-) CAGCAG/CAG coding_sequence_variant, genic_downstream_transcript_variant, inframe_deletion
rs112652327 uncertain-significance, likely-benign, Hermansky-Pudlak syndrome, not specified 78,181,627(-) G/A coding_sequence_variant, synonymous_variant
rs113301033 likely-benign, not provided, not specified 78,116,161(-) T/C coding_sequence_variant, missense_variant
rs114954951 likely-benign, Hermansky-Pudlak syndrome 78,002,314(-) T/C downstream_transcript_variant
rs115124715 uncertain-significance, Hermansky-Pudlak syndrome 78,002,523(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for AP3B1 Gene

Variant ID Type Subtype PubMed ID
nsv968952 CNV duplication 23825009
nsv956493 CNV deletion 24416366
nsv598700 CNV loss 21841781
nsv328833 CNV deletion 16902084
nsv1114694 CNV deletion 24896259
esv4975 CNV loss 18987735
esv3605504 CNV loss 21293372
esv3605502 CNV loss 21293372
esv3570208 CNV loss 25503493
esv3570207 CNV loss 25503493
esv3566139 CNV deletion 23714750
esv2730333 CNV deletion 23290073
esv2666996 CNV deletion 23128226
esv1469212 CNV deletion 17803354
dgv3103n106 CNV deletion 24896259

Variation tolerance for AP3B1 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AP3B1 Gene

Human Gene Mutation Database (HGMD)
AP3B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AP3B1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP3B1 Gene

Disorders for AP3B1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for AP3B1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hermansky-pudlak syndrome 2
  • albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells
hermansky-pudlak syndrome
  • hps
oculocutaneous albinism
  • albinism, oculocutaneous
storage pool platelet disease
  • platelet storage pool deficiency
hermansky-pudlak syndrome 1
  • hps1
- elite association - COSMIC cancer census association via MalaCards
Search AP3B1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AP3B1_HUMAN
  • Hermansky-Pudlak syndrome 2 (HPS2) [MIM:608233]: A form of Hermansky-Pudlak syndrome, a genetically heterogeneous autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. HPS2 differs from the other forms of HPS in that it includes immunodeficiency in its phenotype and patients with HPS2 have an increased susceptibility to infections. {ECO:0000269 PubMed:10024875}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for AP3B1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AP3B1: view

No data available for Genatlas for AP3B1 Gene

Publications for AP3B1 Gene

  1. Beta3A-adaptin, a subunit of the adaptor-like complex AP-3. (PMID: 9182526) Dell'Angelica EC … Bonifacino JS (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. Pigmentation-related genes and their implication in malignant melanoma susceptibility. (PMID: 19320733) Fernandez LP … Ribas G (Experimental dermatology 2009) 3 22 44 58
  3. Characterization of the adaptor-related protein complex, AP-3. (PMID: 9151686) Simpson F … Robinson MS (The Journal of cell biology 1997) 2 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for AP3B1 Gene

  • Addgene plasmids for AP3B1

Sources for AP3B1 Gene

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