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Aliases for AP2B1 Gene

Aliases for AP2B1 Gene

  • Adaptor Related Protein Complex 2 Beta 1 Subunit 2 3 5
  • Clathrin Assembly Protein Complex 2 Beta Large Chain 3 4
  • Plasma Membrane Adaptor HA2/AP2 Adaptin Beta Subunit 3 4
  • Adaptor-Related Protein Complex 2 Subunit Beta 3 4
  • Adaptor Protein Complex AP-2 Subunit Beta 3 4
  • Beta-2-Adaptin 3 4
  • Beta-Adaptin 3 4
  • CLAPB1 3 4
  • AP105B 3 4
  • ADTB2 3 4
  • Clathrin-Associated/Assembly/Adaptor Protein, Large, Beta 1 3
  • Adaptor-Related Protein Complex 2, Beta 1 Subunit 2
  • Adapter-Related Protein Complex 2 Beta Subunit 3
  • Adapter-Related Protein Complex 2 Subunit Beta 3
  • Testicular Tissue Protein Li 22 3
  • AP-2 Complex Subunit Beta 3
  • Adaptin, Beta 2 (Beta) 3
  • AP2-BETA 3

External Ids for AP2B1 Gene

Previous HGNC Symbols for AP2B1 Gene

  • ADTB2
  • CLAPB1

Previous GeneCards Identifiers for AP2B1 Gene

  • GC17P033684
  • GC17P035950
  • GC17P033762
  • GC17P034059
  • GC17P030938
  • GC17P033914
  • GC17P030099

Summaries for AP2B1 Gene

Entrez Gene Summary for AP2B1 Gene

  • The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AP2B1 Gene

AP2B1 (Adaptor Related Protein Complex 2 Beta 1 Subunit) is a Protein Coding gene. Diseases associated with AP2B1 include Ataxia-Telangiectasia. Among its related pathways are EPH-Ephrin signaling and Endocytic Trafficking of EGFR. Gene Ontology (GO) annotations related to this gene include binding and clathrin binding. An important paralog of this gene is AP1B1.

UniProtKB/Swiss-Prot for AP2B1 Gene

  • Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.

Gene Wiki entry for AP2B1 Gene

Additional gene information for AP2B1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP2B1 Gene

Genomics for AP2B1 Gene

GeneHancer (GH) Regulatory Elements for AP2B1 Gene

Promoters and enhancers for AP2B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I035586 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 578 +11.2 11183 5.4 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 AP2B1 PEX12 LIG3 LINC02001 RASL10B C17orf50 SLFN12L LOC100420062 GAS2L2 GC17M035597
GH17I035576 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 569.8 +0.1 79 3.2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 AP2B1 PEX12 ZNF830 LIG3 LOC100420062 GAS2L2
GH17I035567 Promoter/Enhancer 1.6 Ensembl ENCODE 36.4 -9.6 -9574 2.9 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LINC02001 LIG3 ZNF830 PEX12 AP2B1 RAD51D LOC100420062 GAS2L2 GC17P035575 GC17P035574
GH17I035533 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.6 -40.4 -40373 9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZNF2 IRF4 YY1 ARID2 ZNF143 SLFN12L AP2B1 CCL5 ZNF830 PEX12 LIG3 SLFN5 TAF5LP1 GAS2L2 SLFN11
GH17I035763 Enhancer 1.3 Ensembl ENCODE 19.6 +187.5 187497 3.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF213 ZNF143 ZNF548 KLF13 LIG3 ZNF830 LINC02001 PEX12 AP2B1 C17orf50 GAS2L2 CCT6B RAD51D GC17P035762
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AP2B1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AP2B1 gene promoter:

Genomic Locations for AP2B1 Gene

Genomic Locations for AP2B1 Gene
chr17:35,578,046-35,726,417
(GRCh38/hg38)
Size:
148,372 bases
Orientation:
Plus strand
chr17:33,905,065-34,053,436
(GRCh37/hg19)

Genomic View for AP2B1 Gene

Genes around AP2B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP2B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP2B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP2B1 Gene

Proteins for AP2B1 Gene

  • Protein details for AP2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63010-AP2B1_HUMAN
    Recommended name:
    AP-2 complex subunit beta
    Protein Accession:
    P63010
    Secondary Accessions:
    • A6NJP3
    • P21851
    • Q7Z451
    • Q96J19

    Protein attributes for AP2B1 Gene

    Size:
    937 amino acids
    Molecular mass:
    104553 Da
    Quaternary structure:
    • Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with EPN1. Interacts with EPS15; clathrin competes with EPS15. Interacts with SNAP91; clathrin competes with SNAP91. Interacts with CLTC; clathrin competes with EPS15, SNAP91 and PIP5K1C. Interacts with LDLRAP1. Interacts with AMPH and BIN1. Interacts with ARF6 (GDP-bound). Interacts (dephosphorylated at Tyr-737) with ARRB1; phosphorylation of AP2B1 at Tyr-737 disrupts the interaction. Interacts with SLC2A8. Interacts with SCYL1 and SCYL2. Interacts with TGFBR1 and TGFBR2. Interacts with PIP5K1C; clathrin competes with PIP5K1C (By similarity). Interacts with DENND1B, but not with DENND1A, nor DENND1C. Interacts with FCHO1.

    Three dimensional structures from OCA and Proteopedia for AP2B1 Gene

    Alternative splice isoforms for AP2B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP2B1 Gene

Post-translational modifications for AP2B1 Gene

  • Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs).
  • Ubiquitination at posLast=538538 and posLast=917917

No data available for DME Specific Peptides for AP2B1 Gene

Domains & Families for AP2B1 Gene

Gene Families for AP2B1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P63010

UniProtKB/Swiss-Prot:

AP2B1_HUMAN :
  • Belongs to the adaptor complexes large subunit family.
Family:
  • Belongs to the adaptor complexes large subunit family.
genes like me logo Genes that share domains with AP2B1: view

Function for AP2B1 Gene

Molecular function for AP2B1 Gene

UniProtKB/Swiss-Prot Function:
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.

Phenotypes From GWAS Catalog for AP2B1 Gene

Gene Ontology (GO) - Molecular Function for AP2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005048 signal sequence binding TAS 12121421
GO:0005515 protein binding IPI 9341158
GO:0008565 protein transporter activity IEA --
GO:0030276 clathrin binding IEA,TAS 12121421
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with AP2B1: view
genes like me logo Genes that share phenotypes with AP2B1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AP2B1 Gene

Localization for AP2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP2B1 Gene

Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AP2B1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
endosome 5
lysosome 4
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AP2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005802 trans-Golgi network IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005905 clathrin-coated pit IEA --
genes like me logo Genes that share ontologies with AP2B1: view

Pathways & Interactions for AP2B1 Gene

genes like me logo Genes that share pathways with AP2B1: view

SIGNOR curated interactions for AP2B1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for AP2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003281 ventricular septum development IEA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006897 endocytosis IEA --
GO:0007018 microtubule-based movement TAS --
genes like me logo Genes that share ontologies with AP2B1: view

Drugs & Compounds for AP2B1 Gene

(2) Drugs for AP2B1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with AP2B1: view

Transcripts for AP2B1 Gene

Unigene Clusters for AP2B1 Gene

Adaptor-related protein complex 2, beta 1 subunit:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP2B1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ·
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7: -
SP8:
SP9:

ExUns: 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c
SP1: - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for AP2B1 Gene

GeneLoc Exon Structure for
AP2B1
ECgene alternative splicing isoforms for
AP2B1

Expression for AP2B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AP2B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AP2B1 Gene

This gene is overexpressed in Brain (11.8) and Frontal cortex (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AP2B1 Gene



Protein tissue co-expression partners for AP2B1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AP2B1 Gene:

AP2B1

SOURCE GeneReport for Unigene cluster for AP2B1 Gene:

Hs.514819

Evidence on tissue expression from TISSUES for AP2B1 Gene

  • Nervous system(5)
  • Liver(4.4)
  • Muscle(4.4)
  • Kidney(3.4)
  • Lung(3.4)
  • Heart(2.9)
  • Intestine(2.7)
  • Eye(2.4)
  • Adrenal gland(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with AP2B1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AP2B1 Gene

Orthologs for AP2B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP2B1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ap2b1 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AP2B1 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia AP2B1 33 34
  • 94.6 (n)
cow
(Bos Taurus)
Mammalia AP2B1 33 34
  • 94.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AP2B1 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap2b1 33
  • 92.6 (n)
oppossum
(Monodelphis domestica)
Mammalia AP2B1 34
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves AP2B1 33 34
  • 83.07 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ap2b1 33
  • 80.51 (n)
MGC75877 33
African clawed frog
(Xenopus laevis)
Amphibia ap2b1-prov 33
zebrafish
(Danio rerio)
Actinopterygii ap2b1 33 34
  • 79.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bap 35 34
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea apb-1 34
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APL2 34
  • 36 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.5414 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 73 (a)
ManyToMany
CSA.9795 34
  • 54 (a)
ManyToMany
Species where no ortholog for AP2B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AP2B1 Gene

ENSEMBL:
Gene Tree for AP2B1 (if available)
TreeFam:
Gene Tree for AP2B1 (if available)

Paralogs for AP2B1 Gene

Paralogs for AP2B1 Gene

Pseudogenes.org Pseudogenes for AP2B1 Gene

genes like me logo Genes that share paralogs with AP2B1: view

Variants for AP2B1 Gene

Sequence variations from dbSNP and Humsavar for AP2B1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000079994 -- 35,597,585(+) T/C intron_variant
rs1000113351 -- 35,589,236(+) T/G intron_variant
rs1000140667 -- 35,641,184(+) A/G intron_variant
rs1000156535 -- 35,609,522(+) A/G intron_variant
rs1000157716 -- 35,664,512(+) C/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AP2B1 Gene

Variant ID Type Subtype PubMed ID
nsv960466 CNV duplication 23825009
nsv438273 CNV loss 16468122
nsv2038 CNV insertion 18451855
nsv1134643 CNV deletion 24896259
nsv1123124 CNV deletion 24896259
nsv1062793 CNV loss 25217958
esv3892999 CNV loss 25118596
esv3640456 CNV loss 21293372
esv3640454 CNV loss 21293372
esv3361978 CNV insertion 20981092
esv2647158 CNV deletion 19546169
dgv52n17 CNV loss 16327808

Variation tolerance for AP2B1 Gene

Residual Variation Intolerance Score: 4.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AP2B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AP2B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP2B1 Gene

Disorders for AP2B1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AP2B1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ataxia-telangiectasia
  • at
- elite association - COSMIC cancer census association via MalaCards
Search AP2B1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AP2B1

genes like me logo Genes that share disorders with AP2B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AP2B1 Gene

Publications for AP2B1 Gene

  1. The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin. (PMID: 14530274) Rappoport JZ … Simon SM (The Journal of biological chemistry 2003) 3 4 22 58
  2. beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin. (PMID: 11777907) Laporte SA … Caron MG (The Journal of biological chemistry 2002) 3 4 22 58
  3. The structure and function of the beta 2-adaptin appendage domain. (PMID: 10944104) Owen DJ … Evans PR (The EMBO journal 2000) 3 4 22 58
  4. Conservation and diversity in families of coated vesicle adaptins. (PMID: 1969413) Ponnambalam S … Parham P (The Journal of biological chemistry 1990) 3 4 22 58
  5. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 44 58

Products for AP2B1 Gene

Sources for AP2B1 Gene

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