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This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
AP1M2 (Adaptor Related Protein Complex 1 Subunit Mu 2) is a Protein Coding gene. Diseases associated with AP1M2 include Pettigrew Syndrome and Chromophobe Renal Cell Carcinoma. Among its related pathways are Lysosome and Clathrin derived vesicle budding. An important paralog of this gene is AP1M1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16189514 |
GO:0035615 | clathrin adaptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005623 | cell | IEA | -- |
GO:0005765 | lysosomal membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Clathrin derived vesicle budding | ||
2 | HIV Life Cycle |
.65
|
.45
|
3 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | ||
4 | Vesicle-mediated transport | ||
5 | Human cytomegalovirus infection |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006605 | protein targeting | TAS | 10338135 |
GO:0006886 | intracellular protein transport | IEA | -- |
GO:0006903 | vesicle targeting | TAS | 10338135 |
GO:0015031 | protein transport | IEA | -- |
GO:0016192 | vesicle-mediated transport | IEA,IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AP1M2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | AP1M2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | AP1M2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AP1M2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AP1M2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ap1m2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ap1m2 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | AP1M2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | AP1M2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ap1m2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ap1m2 30 31 |
|
OneToOne | |
Dr.20705 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9527 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | AP-47 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | unc-101 31 32 |
|
ManyToMany | |
apm-1 30 31 32 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | APM1 31 |
|
OneToMany | |
APM2 33 |
|
|
|||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10081 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.3839 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.6301 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os.38379 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.8549 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.14288 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2288 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
pettigrew syndrome |
|
|
chromophobe renal cell carcinoma |
|
|
mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma |
|
|
branchiootorenal syndrome 1 |
|
|