Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex ... See more...

Aliases for AP1G2 Gene

Aliases for AP1G2 Gene

  • Adaptor Related Protein Complex 1 Subunit Gamma 2 2 3 5
  • Adaptor Related Protein Complex 1 Gamma 2 Subunit 2 3
  • AP-1 Complex Subunit Gamma-Like 2 3 4
  • Gamma2-Adaptin 3 4
  • G2AD 2 3
  • Clathrin-Associated/Assembly/Adaptor Protein, Large, Gamma-2 3
  • Adaptor-Related Protein Complex 1, Gamma 2 Subunit 2
  • AP1G2 5
  • G2ad 4

External Ids for AP1G2 Gene

Previous GeneCards Identifiers for AP1G2 Gene

  • GC14M021401
  • GC14M017817
  • GC14M022018
  • GC14M023098
  • GC14M024028
  • GC14M004145

Summaries for AP1G2 Gene

Entrez Gene Summary for AP1G2 Gene

  • Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]

GeneCards Summary for AP1G2 Gene

AP1G2 (Adaptor Related Protein Complex 1 Subunit Gamma 2) is a Protein Coding gene. Diseases associated with AP1G2 include Long Qt Syndrome 1. Among its related pathways are Lysosome and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is AP1G1.

UniProtKB/Swiss-Prot Summary for AP1G2 Gene

  • May function in protein sorting in late endosomes or multivesucular bodies (MVBs).
  • (Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV).

Gene Wiki entry for AP1G2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AP1G2 Gene

Genomics for AP1G2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AP1G2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AP1G2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AP1G2

Top Transcription factor binding sites by QIAGEN in the AP1G2 gene promoter:
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • COMP1
  • E47
  • GATA-1
  • Pax-5
  • RSRFC4
  • Sp1
  • Tal-1beta

Genomic Locations for AP1G2 Gene

Genomic Locations for AP1G2 Gene
chr14:23,559,565-23,568,070
(GRCh38/hg38)
Size:
8,506 bases
Orientation:
Minus strand
chr14:24,028,774-24,037,279
(GRCh37/hg19)
Size:
8,506 bases
Orientation:
Minus strand

Genomic View for AP1G2 Gene

Genes around AP1G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1G2 Gene

Proteins for AP1G2 Gene

  • Protein details for AP1G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75843-AP1G2_HUMAN
    Recommended name:
    AP-1 complex subunit gamma-like 2
    Protein Accession:
    O75843
    Secondary Accessions:
    • D3DS51
    • O75504

    Protein attributes for AP1G2 Gene

    Size:
    785 amino acids
    Molecular mass:
    87117 Da
    Quaternary structure:
    • Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Binds ubiquitin.
    • (Microbial infection) Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner.
    SequenceCaution:
    • Sequence=AAC67390.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AP1G2 Gene

neXtProt entry for AP1G2 Gene

Post-translational modifications for AP1G2 Gene

  • Ubiquitination at Lys7, Lys145, and Lys584
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AP1G2 Gene

Domains & Families for AP1G2 Gene

Protein Domains for AP1G2 Gene

InterPro:
Blocks:
  • Alpha/gamma adaptin, C-terminal
  • Gamma-adaptin, C-terminal
  • Adaptin, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for AP1G2 Gene

GenScript: Design optimal peptide antigens:
  • Gamma2-adaptin (AP1G2_HUMAN)
  • cDNA FLJ56213, highly similar to Adapter-relatedprotein complex 1 gamma- 2 subunit (B4E3E1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75843

UniProtKB/Swiss-Prot:

AP1G2_HUMAN :
  • Belongs to the adaptor complexes large subunit family.
Family:
  • Belongs to the adaptor complexes large subunit family.
genes like me logo Genes that share domains with AP1G2: view

Function for AP1G2 Gene

Molecular function for AP1G2 Gene

UniProtKB/Swiss-Prot Function:
May function in protein sorting in late endosomes or multivesucular bodies (MVBs).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV).

Phenotypes From GWAS Catalog for AP1G2 Gene

Gene Ontology (GO) - Molecular Function for AP1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12505986
GO:0035615 clathrin adaptor activity IBA 21873635
genes like me logo Genes that share ontologies with AP1G2: view
genes like me logo Genes that share phenotypes with AP1G2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AP1G2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AP1G2 Gene

Localization for AP1G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1G2 Gene

Golgi apparatus membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasmic vesicle membrane. Peripheral membrane protein. Endosome membrane. Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AP1G2 gene
Compartment Confidence
golgi apparatus 5
endosome 4
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for AP1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus TAS 9762922
GO:0005798 Golgi-associated vesicle IDA 9762922
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with AP1G2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AP1G2 Gene

Pathways & Interactions for AP1G2 Gene

genes like me logo Genes that share pathways with AP1G2: view

Pathways by source for AP1G2 Gene

1 GeneGo (Thomson Reuters) pathway for AP1G2 Gene
  • Transport Clathrin-coated vesicle cycle
1 Qiagen pathway for AP1G2 Gene
  • CTLA4 Signaling

Gene Ontology (GO) - Biological Process for AP1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006896 Golgi to vacuole transport IBA 21873635
GO:0006898 receptor-mediated endocytosis IBA 21873635
GO:0015031 protein transport IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with AP1G2: view

No data available for SIGNOR curated interactions for AP1G2 Gene

Drugs & Compounds for AP1G2 Gene

No Compound Related Data Available

Transcripts for AP1G2 Gene

mRNA/cDNA for AP1G2 Gene

9 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
34 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AP1G2

Alternative Splicing Database (ASD) splice patterns (SP) for AP1G2 Gene

No ASD Table

Relevant External Links for AP1G2 Gene

GeneLoc Exon Structure for
AP1G2

Expression for AP1G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AP1G2 Gene

Protein differential expression in normal tissues from HIPED for AP1G2 Gene

This gene is overexpressed in Lymph node (15.5), Peripheral blood mononuclear cells (11.4), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AP1G2 Gene



Protein tissue co-expression partners for AP1G2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AP1G2

SOURCE GeneReport for Unigene cluster for AP1G2 Gene:

Hs.343244

mRNA Expression by UniProt/SwissProt for AP1G2 Gene:

O75843-AP1G2_HUMAN
Tissue specificity: Expressed in all but one (skeletal muscle) tissues examined.

Evidence on tissue expression from TISSUES for AP1G2 Gene

  • Liver(4.3)
  • Nervous system(2.6)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with AP1G2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AP1G2 Gene

Orthologs for AP1G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AP1G2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AP1G2 30 31
  • 99.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AP1G2 30 31
  • 89.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AP1G2 30 31
  • 88.47 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ap1g2 30 17 31
  • 86.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100362547 30
  • 86.22 (n)
Oppossum
(Monodelphis domestica)
Mammalia AP1G2 31
  • 79 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ap1g2 31
  • 55 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta AP-1gamma 31 32
  • 40 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea apg-1 31
  • 41 (a)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADR064C 30
  • 45.88 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06579g 30
  • 43.58 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APL4 30 31
  • 43.51 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToMany
Species where no ortholog for AP1G2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for AP1G2 Gene

ENSEMBL:
Gene Tree for AP1G2 (if available)
TreeFam:
Gene Tree for AP1G2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AP1G2: view image

Paralogs for AP1G2 Gene

Paralogs for AP1G2 Gene

(2) SIMAP similar genes for AP1G2 Gene using alignment to 7 proteins:

  • AP1G2_HUMAN
  • G3V2V9_HUMAN
  • G3V3Z2_HUMAN
  • G3V532_HUMAN
  • H0YJ08_HUMAN
  • H0YJ47_HUMAN
  • L8EA67_HUMAN
genes like me logo Genes that share paralogs with AP1G2: view

Variants for AP1G2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AP1G2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
916555 Likely Pathogenic: Tracheoesophageal fistula 23,566,285(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
rs12897422 - p.Ser377Phe

Additional dbSNP identifiers (rs#s) for AP1G2 Gene

Structural Variations from Database of Genomic Variants (DGV) for AP1G2 Gene

Variant ID Type Subtype PubMed ID
nsv564044 CNV loss 21841781
nsv952817 CNV deletion 24416366

Variation tolerance for AP1G2 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AP1G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AP1G2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP1G2 Gene

Disorders for AP1G2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AP1G2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
long qt syndrome 1
  • lqt1
- elite association - COSMIC cancer census association via MalaCards
Search AP1G2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AP1G2

genes like me logo Genes that share disorders with AP1G2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AP1G2 Gene

Publications for AP1G2 Gene

  1. Identification and characterization of novel clathrin adaptor-related proteins. (PMID: 9733768) Takatsu H … Nakayama K (The Journal of biological chemistry 1998) 2 3 4 23
  2. Cloning, expression, and localization of a novel gamma-adaptin-like molecule. (PMID: 9762922) Lewin DA … Mellman I (FEBS letters 1998) 2 3 4 23
  3. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 41
  4. gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway. (PMID: 18772139) Rost M … Prange R (The Journal of biological chemistry 2008) 3 23
  5. Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. (PMID: 17553870) Lambert C … Prange R (Journal of virology 2007) 3 4

Products for AP1G2 Gene

Sources for AP1G2 Gene