Aliases for AP1AR Gene

Aliases for AP1AR Gene

  • Adaptor Related Protein Complex 1 Associated Regulatory Protein 2 3 5
  • Gamma-BAR 2 3 4
  • Gamma-1-Adaptin Brefeldin A Resistance Protein 3 4
  • AP-1 Complex-Associated Regulatory Protein 3 4
  • Gamma-A1-Adaptin And Kinesin Interactor 3 4
  • C4orf16 3 4
  • PRO0971 2 3
  • Gadkin 3 4
  • 2C18 2 3
  • GBAR 3 4
  • Adaptor-Related Protein Complex 1 Associated Regulatory Protein 2
  • Adapter-Related Protein Complex 1-Associated Regulatory Protein 3
  • Adaptor-Related Protein Complex 1-Associated Regulatory Protein 4
  • Gamma1-Adaptin Brefeldin A Resistance Protein, Gamma-BAR 3
  • Gamma1-Adaptin Brefeldin A Resistance 2
  • Chromosome 4 Open Reading Frame 16 2
  • AP1AR 5
  • 2c18 4

External Ids for AP1AR Gene

Previous HGNC Symbols for AP1AR Gene

  • C4orf16

Previous GeneCards Identifiers for AP1AR Gene

  • GC04P113373
  • GC04P113153
  • GC04P108884

Summaries for AP1AR Gene

GeneCards Summary for AP1AR Gene

AP1AR (Adaptor Related Protein Complex 1 Associated Regulatory Protein) is a Protein Coding gene. Diseases associated with AP1AR include Gliosarcoma. Gene Ontology (GO) annotations related to this gene include kinesin binding and AP-1 adaptor complex binding.

UniProtKB/Swiss-Prot Summary for AP1AR Gene

  • Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

Gene Wiki entry for AP1AR Gene

Additional gene information for AP1AR Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AP1AR Gene

Genomics for AP1AR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AP1AR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AP1AR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AP1AR

Genomic Locations for AP1AR Gene

Genomic Locations for AP1AR Gene
chr4:112,231,740-112,273,110
(GRCh38/hg38)
Size:
41,371 bases
Orientation:
Plus strand
chr4:113,152,893-113,191,211
(GRCh37/hg19)
Size:
38,319 bases
Orientation:
Plus strand

Genomic View for AP1AR Gene

Genes around AP1AR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1AR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1AR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1AR Gene

Proteins for AP1AR Gene

  • Protein details for AP1AR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HQ0-AP1AR_HUMAN
    Recommended name:
    AP-1 complex-associated regulatory protein
    Protein Accession:
    Q63HQ0
    Secondary Accessions:
    • B2RCV7
    • Q96GG6
    • Q9H0V0
    • Q9P1L4

    Protein attributes for AP1AR Gene

    Size:
    302 amino acids
    Molecular mass:
    34280 Da
    Quaternary structure:
    • Interacts (via coiled-coil domain) with AP1G1 (via GAE domain). Interacts with KIF5B. Associates with the Arp2/3 complex.
    SequenceCaution:
    • Sequence=AAF71037.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for AP1AR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1AR Gene

Post-translational modifications for AP1AR Gene

Other Protein References for AP1AR Gene

No data available for DME Specific Peptides for AP1AR Gene

Domains & Families for AP1AR Gene

Gene Families for AP1AR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AP1AR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AP1AR Gene

GenScript: Design optimal peptide antigens:
  • Gamma-1-adaptin brefeldin A resistance protein (AP1AR_HUMAN)
genes like me logo Genes that share domains with AP1AR: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AP1AR Gene

Function for AP1AR Gene

Molecular function for AP1AR Gene

UniProtKB/Swiss-Prot Function:
Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

Phenotypes From GWAS Catalog for AP1AR Gene

Gene Ontology (GO) - Molecular Function for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019894 kinesin binding IBA,IDA 19706427
GO:0035650 AP-1 adaptor complex binding IEA,IDA 19706427
genes like me logo Genes that share ontologies with AP1AR: view
genes like me logo Genes that share phenotypes with AP1AR: view

Animal Models for AP1AR Gene

MGI Knock Outs for AP1AR:
  • Ap1ar Ap1ar<tm2b(EUCOMM)Hmgu>
  • Ap1ar Ap1ar<tm1.1Vha>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AP1AR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AP1AR Gene

Localization for AP1AR Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1AR Gene

Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AP1AR gene
Compartment Confidence
endosome 5
golgi apparatus 5
nucleus 3
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA 21873635
GO:0005769 early endosome IEA --
GO:0005770 late endosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AP1AR: view

Pathways & Interactions for AP1AR Gene

PathCards logo

SuperPathways for AP1AR Gene

No Data Available

Gene Ontology (GO) - Biological Process for AP1AR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001920 negative regulation of receptor recycling IMP 19706427
GO:0015031 protein transport IEA --
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IEA --
GO:0034613 cellular protein localization IEA --
GO:0048203 vesicle targeting, trans-Golgi to endosome IEA,IDA 19706427
genes like me logo Genes that share ontologies with AP1AR: view

No data available for Pathways by source and SIGNOR curated interactions for AP1AR Gene

Drugs & Compounds for AP1AR Gene

No Compound Related Data Available

Transcripts for AP1AR Gene

mRNA/cDNA for AP1AR Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AP1AR

Alternative Splicing Database (ASD) splice patterns (SP) for AP1AR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for AP1AR Gene

GeneLoc Exon Structure for
AP1AR

Expression for AP1AR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AP1AR Gene

Protein differential expression in normal tissues from HIPED for AP1AR Gene

This gene is overexpressed in Testis (50.4) and Blymphocyte (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AP1AR Gene



Protein tissue co-expression partners for AP1AR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AP1AR

SOURCE GeneReport for Unigene cluster for AP1AR Gene:

Hs.435991

Evidence on tissue expression from TISSUES for AP1AR Gene

  • Nervous system(4.5)
  • Pancreas(4.2)
  • Liver(2.7)
  • Skin(2.5)
  • Kidney(2.4)
  • Intestine(2.3)
  • Blood(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with AP1AR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AP1AR Gene

Orthologs for AP1AR Gene

This gene was present in the common ancestor of chordates.

Orthologs for AP1AR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AP1AR 30 31
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AP1AR 30 31
  • 94.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AP1AR 30
  • 94.59 (n)
MGC155012 31
  • 94 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 88 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 86 (a)
OneToMany
-- 31
  • 66 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Ap1ar 30
  • 85.89 (n)
Mouse
(Mus musculus)
Mammalia Ap1ar 30 17 31
  • 84 (n)
OneToOne
Chicken
(Gallus gallus)
Aves AP1AR 30 31
  • 81.99 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia AP1AR 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ap1ar 30
  • 74.73 (n)
Str.1425 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.11377 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100332265 30
  • 61.17 (n)
CABZ01003022.1 31
  • 57 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9297 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
OneToOne
Species where no ortholog for AP1AR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AP1AR Gene

ENSEMBL:
Gene Tree for AP1AR (if available)
TreeFam:
Gene Tree for AP1AR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AP1AR: view image

Paralogs for AP1AR Gene

No data available for Paralogs for AP1AR Gene

Variants for AP1AR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AP1AR Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
767972 Benign: not provided 112,268,352(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs34900583 - p.Thr297Ile

Additional dbSNP identifiers (rs#s) for AP1AR Gene

Variation tolerance for AP1AR Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AP1AR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AP1AR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AP1AR Gene

Disorders for AP1AR Gene

MalaCards: The human disease database

(1) MalaCards diseases for AP1AR Gene - From: DISEASES

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards
Search AP1AR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AP1AR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AP1AR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AP1AR Gene

Publications for AP1AR Gene

  1. Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (PMID: 15775984) Neubrand VE … Simpson JC (The EMBO journal 2005) 2 3 4
  2. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. (PMID: 22689987) Maritzen T … Haucke V (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4
  3. Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes. (PMID: 21525240) Laulagnier K … Gruenberg J (Molecular biology of the cell 2011) 3 4
  4. A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR. (PMID: 19965873) Maritzen T … Haucke V (The Journal of biological chemistry 2010) 3 4
  5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 41

Products for AP1AR Gene

Sources for AP1AR Gene