Aliases for AOC2 Gene
External Ids for AOC2 Gene
Previous GeneCards Identifiers for AOC2 Gene
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for AOC2 Gene
AOC2 (Amine Oxidase, Copper Containing 2) is a Protein Coding gene. Diseases associated with AOC2 include Median Neuropathy and Retinitis Pigmentosa. Among its related pathways are Phenylalanine metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include electron transfer activity and quinone binding. An important paralog of this gene is AOC3.
UniProtKB/Swiss-Prot for AOC2 Gene
Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina.