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This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]
AOAH (Acyloxyacyl Hydrolase) is a Protein Coding gene. Diseases associated with AOAH include Acute Ethmoiditis and Xanthogranulomatous Pyelonephritis. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and acyloxyacyl hydrolase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IDA | 29343645 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016788 | hydrolase activity, acting on ester bonds | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO:0050528 | acyloxyacyl hydrolase activity | IDA | 1883828 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0031410 | cytoplasmic vesicle | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IDA | 1883828 |
GO:0008653 | lipopolysaccharide metabolic process | IEA | -- |
GO:0009104 | lipopolysaccharide catabolic process | IDA | 1883828 |
GO:0050728 | negative regulation of inflammatory response | IEA,IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Water | Approved | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AOAH 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AOAH 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AOAH 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Aoah 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Aoah 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | AOAH 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | AOAH 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | AOAH 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | AOAH 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aoah 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2613811 | CNV | deletion | 19546169 |
esv2676624 | CNV | deletion | 23128226 |
esv33783 | CNV | gain | 17666407 |
esv3576308 | CNV | gain | 25503493 |
esv3612835 | CNV | loss | 21293372 |
nsv1016732 | CNV | gain | 25217958 |
nsv1032157 | CNV | gain | 25217958 |
nsv1115738 | CNV | duplication | 24896259 |
nsv1125426 | OTHER | inversion | 24896259 |
nsv1137210 | CNV | deletion | 24896259 |
nsv366801 | CNV | deletion | 16902084 |
nsv464427 | CNV | loss | 19166990 |
nsv470199 | CNV | loss | 18288195 |
nsv473135 | CNV | novel sequence insertion | 20440878 |
nsv477438 | CNV | novel sequence insertion | 20440878 |
nsv5700 | CNV | insertion | 18451855 |
nsv606618 | CNV | loss | 21841781 |
nsv606619 | CNV | loss | 21841781 |
nsv606620 | CNV | loss | 21841781 |
nsv830957 | CNV | gain | 17160897 |
nsv830958 | CNV | gain | 17160897 |
nsv830960 | CNV | loss | 17160897 |
nsv951630 | CNV | deletion | 24416366 |
nsv957603 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
acute ethmoiditis |
|
|
xanthogranulomatous pyelonephritis |
|
|
chronic frontal sinusitis |
|
|
kartagener syndrome |
|
|
primary ciliary dyskinesia |
|
|