Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANXA8L1 Gene

Aliases for ANXA8L1 Gene

  • Annexin A8 Like 1 2 3 5
  • ANXA8L2 3 4
  • Vascular Anticoagulant-Beta 3
  • Annexin A8-Like Protein 1 3
  • Annexin A8-Like Protein 2 3
  • Annexin A8-Like 2 2
  • Annexin A8L2 3
  • Annexin VIII 3
  • BA145E20.2 3
  • Annexin-8 3
  • VAC-Beta 3
  • ANXA8 3

External Ids for ANXA8L1 Gene

Previous HGNC Symbols for ANXA8L1 Gene

  • ANXA8L2

Previous GeneCards Identifiers for ANXA8L1 Gene

  • GC10U900551
  • GC10M046578
  • GC10M047157

Summaries for ANXA8L1 Gene

Entrez Gene Summary for ANXA8L1 Gene

  • This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Apr 2014]

GeneCards Summary for ANXA8L1 Gene

ANXA8L1 (Annexin A8 Like 1) is a Protein Coding gene. Diseases associated with ANXA8L1 include Bile Duct Adenocarcinoma and Pre-Malignant Neoplasm. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA8.

Additional gene information for ANXA8L1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA8L1 Gene

Genomics for ANXA8L1 Gene

GeneHancer (GH) Regulatory Elements for ANXA8L1 Gene

Promoters and enhancers for ANXA8L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J046375 Promoter/Enhancer 0.7 EPDnew Ensembl 656.1 +0.3 311 1.8 ANXA8L1 ENSG00000285402 ENSG00000279458 PIR39442
GH10J046369 Promoter 0.5 EPDnew 650.4 -6.5 -6527 0.1 ENSG00000279458 FAM25BP ANXA8L1 PIR45682
GH10J046374 Enhancer 0.4 Ensembl 650.7 -1.0 -989 0.4 SMARCA4 REST ENSG00000285402 ANXA8L1 ENSG00000279458
GH10J046522 Enhancer 1.3 Ensembl ENCODE 9.1 +149.1 149108 3.6 HDGF ARNT SIN3A YBX1 ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 FOS PARGP1 AGAP4 BMS1P1 AGAP9 WASHC2C LOC105378289 AGAP10P FAM21FP ZFAND4 FAM35BP
GH10J046313 Enhancer 0.6 ENCODE 13.4 -60.6 -60644 3.4 SMARCE1 TAL1 CBFA2T3 DPF2 ELF1 TCF12 ZNF217 CTBP1 GATA3 NFIC ANXA8L1 LINC00842 PIR43906 ANTXRL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA8L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANXA8L1 gene promoter:
  • E47
  • FAC1
  • MEF-2A
  • MEF-2
  • aMEF-2
  • AML1a
  • SEF-1 (1)
  • PPAR-alpha
  • YY1

Genomic Locations for ANXA8L1 Gene

Genomic Locations for ANXA8L1 Gene
16,195 bases
Plus strand
16,111 bases
Minus strand

Genomic View for ANXA8L1 Gene

Genes around ANXA8L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA8L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA8L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA8L1 Gene

Proteins for ANXA8L1 Gene

  • Protein details for ANXA8L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A8-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A0A0B4J2D4
    • B2R939
    • Q53FY2
    • Q5VT78
    • Q96H89

    Protein attributes for ANXA8L1 Gene

    327 amino acids
    Molecular mass:
    36879 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANXA8L1 Gene


neXtProt entry for ANXA8L1 Gene

Post-translational modifications for ANXA8L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANXA8L1 Gene

No data available for DME Specific Peptides for ANXA8L1 Gene

Domains & Families for ANXA8L1 Gene

Gene Families for ANXA8L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANXA8L1 Gene

Suggested Antigen Peptide Sequences for ANXA8L1 Gene

Graphical View of Domain Structure for InterPro Entry



  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA8L1: view

Function for ANXA8L1 Gene

Phenotypes From GWAS Catalog for ANXA8L1 Gene

Gene Ontology (GO) - Molecular Function for ANXA8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005544 calcium-dependent phospholipid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ANXA8L1: view
genes like me logo Genes that share phenotypes with ANXA8L1: view

miRNA for ANXA8L1 Gene

miRTarBase miRNAs that target ANXA8L1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA8L1 Gene

Localization for ANXA8L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA8L1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
endosome 5
peroxisome 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANXA8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with ANXA8L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA8L1 Gene

Pathways & Interactions for ANXA8L1 Gene

SuperPathways for ANXA8L1 Gene

No Data Available

Interacting Proteins for ANXA8L1 Gene

Gene Ontology (GO) - Biological Process for ANXA8L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANXA8L1 Gene

Drugs & Compounds for ANXA8L1 Gene

(1) Drugs for ANXA8L1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with ANXA8L1: view

Transcripts for ANXA8L1 Gene

mRNA/cDNA for ANXA8L1 Gene

(5) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA8L1 Gene

Annexin A8-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA8L1 Gene

No ASD Table

Relevant External Links for ANXA8L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA8L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA8L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA8L1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x12.2), Esophagus - Mucosa (x11.7), Skin - Sun Exposed (Lower leg) (x11.3), and Vagina (x6.1).

Protein differential expression in normal tissues from HIPED for ANXA8L1 Gene

This gene is overexpressed in Saliva (37.4), Skin (20.4), and Urine (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANXA8L1 Gene

Protein tissue co-expression partners for ANXA8L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANXA8L1 Gene:


SOURCE GeneReport for Unigene cluster for ANXA8L1 Gene:


Evidence on tissue expression from TISSUES for ANXA8L1 Gene

  • Pancreas(4.3)
  • Lung(4.2)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with ANXA8L1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA8L1 Gene

Orthologs for ANXA8L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANXA8L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANXA8L1 33
  • 99.08 (n)
(Bos Taurus)
Mammalia ANXA8L1 33
  • 89.47 (n)
(Canis familiaris)
Mammalia ANXA8L1 33
  • 89.23 (n)
(Mus musculus)
Mammalia Anxa8 16 33
  • 88.45 (n)
(Rattus norvegicus)
Mammalia Anxa8 33
  • 88.34 (n)
(Gallus gallus)
Aves ANXA8 33
  • 72.49 (n)
Species where no ortholog for ANXA8L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANXA8L1 Gene

Gene Tree for ANXA8L1 (if available)
Gene Tree for ANXA8L1 (if available)

Paralogs for ANXA8L1 Gene

Paralogs for ANXA8L1 Gene

(15) SIMAP similar genes for ANXA8L1 Gene using alignment to 3 proteins:

  • F5H7X5_HUMAN
  • Q5T2P7_HUMAN
genes like me logo Genes that share paralogs with ANXA8L1: view

Variants for ANXA8L1 Gene

Sequence variations from dbSNP and Humsavar for ANXA8L1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs10906955 -- 46,375,353(+) A/G upstream_transcript_variant
rs10909681 -- 46,376,741(+) C/G intron_variant
rs111241278 -- 46,391,031(+) C/A/G 3_prime_UTR_variant
rs111611425 -- 46,376,497(+) T/A intron_variant
rs112369793 -- 46,380,288(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA8L1 Gene

Variant ID Type Subtype PubMed ID
dgv1106n54 CNV gain 21841781
dgv1110n54 CNV gain 21841781
dgv1112n54 CNV gain+loss 21841781
dgv1119n54 CNV loss 21841781
dgv135e199 CNV deletion 23128226
dgv765n100 CNV loss 25217958
dgv767n100 CNV gain 25217958
dgv807n100 CNV gain 25217958
dgv817n100 CNV loss 25217958
esv2736152 CNV deletion 23290073
esv3891802 CNV gain 25118596
nsv1041060 CNV gain+loss 25217958
nsv1050225 CNV gain+loss 25217958
nsv1069477 CNV deletion 25765185
nsv1139527 CNV duplication 24896259
nsv1147916 CNV duplication 26484159
nsv1161950 CNV duplication 26073780
nsv437116 CNV loss 16327808
nsv550723 CNV gain 21841781
nsv550758 CNV loss 21841781
nsv820817 CNV duplication 20802225
nsv831853 CNV gain 17160897
nsv831859 CNV gain+loss 17160897
nsv947932 CNV duplication 23825009
nsv947949 CNV duplication 23825009
nsv947950 CNV duplication 23825009

Variation tolerance for ANXA8L1 Gene

Gene Damage Index Score: 1.95; 36.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA8L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA8L1 Gene

Disorders for ANXA8L1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ANXA8L1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ANXA8L1

genes like me logo Genes that share disorders with ANXA8L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA8L1 Gene

Publications for ANXA8L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for ANXA8L1 Gene

Sources for ANXA8L1 Gene

Loading form....