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Aliases for ANXA8 Gene

Aliases for ANXA8 Gene

  • Annexin A8 2 3 3 5
  • Vascular Anticoagulant-Beta 3 4
  • Annexin VIII 3 4
  • Annexin-8 3 4
  • VAC-Beta 3 4
  • ANX8 3 4
  • CH17-360D5.2 3

External Ids for ANXA8 Gene

Previous HGNC Symbols for ANXA8 Gene

  • ANX8

Previous GeneCards Identifiers for ANXA8 Gene

  • GC10M046457
  • GC10P046695
  • GC10P047553
  • GC10P047061
  • GC10P047216
  • GC10P047879
  • GC10P048255

Summaries for ANXA8 Gene

Entrez Gene Summary for ANXA8 Gene

  • This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA8 Gene

ANXA8 (Annexin A8) is a Protein Coding gene. Diseases associated with ANXA8 include Acute Promyelocytic Leukemia. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA8L1.

UniProtKB/Swiss-Prot for ANXA8 Gene

  • This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Additional gene information for ANXA8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA8 Gene

Genomics for ANXA8 Gene

GeneHancer (GH) Regulatory Elements for ANXA8 Gene

Promoters and enhancers for ANXA8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J047990 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 650.7 +2.0 2032 2.1 SP1 SREBF1 KLF1 SIN3A CEBPB FOXA1 ANXA8 ENSG00000276850 PIR46985
GH10J047484 Promoter/Enhancer 0.7 EPDnew Ensembl 650 +509.5 509467 1 ENSG00000270369 ANXA8 PIR62124
GH10J047994 Enhancer 0.2 Ensembl 650.7 -0.6 -632 0.4 ANXA8 FAM25C
GH10J047988 Enhancer 0.4 ENCODE 0.7 +4.5 4480 1.9 SIN3A PRDM10 EGR2 PIR46985 ENSG00000276850 ANXA8
GH10J047986 Promoter 0.5 Ensembl 0.4 +7.1 7067 0.2 PIR46985 ENSG00000276850 ANXA8 ENSG00000273760
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANXA8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANXA8 gene promoter:
  • E47
  • FAC1
  • MEF-2A
  • MEF-2
  • aMEF-2
  • AML1a
  • SEF-1 (1)
  • PPAR-alpha
  • YY1

Genomic Locations for ANXA8 Gene

Genomic Locations for ANXA8 Gene
533,607 bases
Minus strand
23,976 bases
Plus strand

Genomic View for ANXA8 Gene

Genes around ANXA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA8 Gene

Proteins for ANXA8 Gene

  • Protein details for ANXA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A8
    Protein Accession:
    Secondary Accessions:
    • A6NDE6
    • A6NLM1
    • B4DKI1
    • B4DTC9
    • Q5T2P8
    • Q5VTM4
    • Q6GMY3
    • Q9BT34

    Protein attributes for ANXA8 Gene

    327 amino acids
    Molecular mass:
    36881 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ANXA8 Gene

    Alternative splice isoforms for ANXA8 Gene


neXtProt entry for ANXA8 Gene

Post-translational modifications for ANXA8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for ANXA8 (Annexin A8/ANXA8)
  • Boster Bio Antibodies for ANXA8

No data available for DME Specific Peptides for ANXA8 Gene

Domains & Families for ANXA8 Gene

Gene Families for ANXA8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ANXA8 Gene

Suggested Antigen Peptide Sequences for ANXA8 Gene

Graphical View of Domain Structure for InterPro Entry



  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA8: view

Function for ANXA8 Gene

Molecular function for ANXA8 Gene

UniProtKB/Swiss-Prot Function:
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
GENATLAS Biochemistry:
annexin A8,calcium and phospholipid binding protein,vascular anticoagulation

Gene Ontology (GO) - Molecular Function for ANXA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 15644210
GO:0005544 calcium-dependent phospholipid binding IEA,IDA 2530088
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 16638567
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 16638567
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 16638567
genes like me logo Genes that share ontologies with ANXA8: view
genes like me logo Genes that share phenotypes with ANXA8: view

Animal Model Products

miRNA for ANXA8 Gene

miRTarBase miRNAs that target ANXA8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANXA8 Gene

Localization for ANXA8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA8 gene
Compartment Confidence
plasma membrane 5
cytosol 5
endosome 5
peroxisome 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANXA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 18923148
GO:0005886 plasma membrane IDA 18923148
GO:0031902 late endosome membrane IDA 18923148
genes like me logo Genes that share ontologies with ANXA8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA8 Gene

Pathways & Interactions for ANXA8 Gene

SuperPathways for ANXA8 Gene

No Data Available

Interacting Proteins for ANXA8 Gene

Gene Ontology (GO) - Biological Process for ANXA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007032 endosome organization IMP 18923148
GO:0007596 blood coagulation IEA --
GO:0007599 hemostasis IEA --
GO:0016197 endosomal transport IMP 18923148
GO:1900004 negative regulation of serine-type endopeptidase activity IDA 2530088
genes like me logo Genes that share ontologies with ANXA8: view

No data available for Pathways by source and SIGNOR curated interactions for ANXA8 Gene

Drugs & Compounds for ANXA8 Gene

(1) Drugs for ANXA8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with ANXA8: view

Transcripts for ANXA8 Gene

mRNA/cDNA for ANXA8 Gene

(8) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANXA8 Gene

Annexin A8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA8 Gene

No ASD Table

Relevant External Links for ANXA8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA8 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.7), Skin - Not Sun Exposed (Suprapubic) (x9.1), Vagina (x7.5), and Skin - Sun Exposed (Lower leg) (x6.9).

Protein differential expression in normal tissues from HIPED for ANXA8 Gene

This gene is overexpressed in Cervix (33.0), Skin (14.6), and Saliva (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANXA8 Gene

Protein tissue co-expression partners for ANXA8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANXA8 Gene:


SOURCE GeneReport for Unigene cluster for ANXA8 Gene:


Evidence on tissue expression from TISSUES for ANXA8 Gene

  • Pancreas(4.3)
  • Lung(4.2)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with ANXA8: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA8 Gene

Orthologs for ANXA8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANXA8L1 33
  • 98.98 (n)
(Bos Taurus)
Mammalia ANXA8L1 33
  • 89.78 (n)
(Canis familiaris)
Mammalia ANXA8L1 33
  • 89.33 (n)
(Mus musculus)
Mammalia Anxa8 33
  • 88.75 (n)
(Rattus norvegicus)
Mammalia Anxa8 33
  • 88.65 (n)
(Gallus gallus)
Aves ANXA8 33
  • 72.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 35
  • 49 (a)
AnnX 35
  • 48 (a)
Anxb11 35
  • 46 (a)
(Caenorhabditis elegans)
Secernentea nex-2 35
  • 47 (a)
nex-1 35
  • 42 (a)
nex-3 35
  • 35 (a)
Species where no ortholog for ANXA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ANXA8 Gene

Gene Tree for ANXA8 (if available)
Gene Tree for ANXA8 (if available)
Evolutionary constrained regions (ECRs) for ANXA8: view image

Paralogs for ANXA8 Gene

Paralogs for ANXA8 Gene

(15) SIMAP similar genes for ANXA8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANXA8: view

Variants for ANXA8 Gene

Sequence variations from dbSNP and Humsavar for ANXA8 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1009474 -- 47,589,556(-) G/T genic_upstream_transcript_variant, intron_variant
rs10219043 -- 47,896,818(-) G/A genic_upstream_transcript_variant, intron_variant
rs1028563248 -- 47,988,908(-) G/A genic_upstream_transcript_variant, intron_variant
rs1045723 -- 47,529,706(-) C/T genic_upstream_transcript_variant, intron_variant
rs10466322 -- 47,901,060(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA8 Gene

Variant ID Type Subtype PubMed ID
nsv1118173 CNV deletion 24896259
nsv831861 CNV loss 17160897
nsv947961 CNV duplication 23825009

Additional Variant Information for ANXA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ANXA8 Gene

Disorders for ANXA8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANXA8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute promyelocytic leukemia
  • apl
- elite association - COSMIC cancer census association via MalaCards
Search ANXA8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ANXA8

genes like me logo Genes that share disorders with ANXA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA8 Gene

Publications for ANXA8 Gene

  1. The crystal structure of annexin A8 is similar to that of annexin A3. (PMID: 15644210) Réty S … Lewit-Bentley A (Journal of molecular biology 2005) 3 4 58
  2. TaqI polymorphisms at the annexin VIII locus (ANX8). (PMID: 1364010) Chambers JA … Mulligan LM (Human molecular genetics 1992) 2 3 58
  3. Specific expression of the annexin VIII gene in acute promyelocytic leukemia. (PMID: 1313714) Chang KS … Stass SA (Blood 1992) 3 4 58
  4. Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. (PMID: 2530088) Hauptmann R … Reutelingsperger CP (European journal of biochemistry 1989) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ANXA8 Gene

Sources for ANXA8 Gene

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